scholarly journals Simultaneous Viscum Pleurodesis and Bullectomy in Patients With Primary Spontaneous Pneumothorax

2021 ◽  
Author(s):  
Hee Suk Jung ◽  
Hyun Jung Kim
Keyword(s):  
Spontaneous Pneumothorax ◽  
Operating Time ◽  
Viscum Album ◽  
Polyglycolic Acid ◽  
Primary Spontaneous Pneumothorax ◽  
Tube Placement ◽  
Effective Treatment Option ◽  
Indwelling Time ◽  
The Mean ◽  
Grade 3

Abstract Objectives: Although surgery is the gold standard for treatment of primary spontaneous pneumothorax (PSP), recurrence after surgery remains a concern. This study sought to evaluate the efficacy of simultaneous pleurodesis using Viscum album (VA) extract and bullectomy for the treatment of PSP.Methods: From March 2016 to November 2020, 196 patients with PSP underwent bullectomy and intraoperative pleurodesis with VA extract at a single institution. All operations were performed through video-assisted thoracic surgery by one surgeon. Upon completion of bullectomy, a polyglycolic acid sheet was used to cover the stapler lines, and 40 mg of VA extract was instilled over the entire chest wall before chest tube placement.Results: The mean operating time was 18.5±5.0 minutes (range, 10­–65) and the mean indwelling time of chest drainage was 1.8±0.5 days (range, 2–6). There were no postoperative complications over grade 3. During the median follow-up period of 36.3±18.4 months (range, 2–57), no recurrence of pneumothorax was observed.Conclusions: The results of this study demonstrated that simultaneous Viscum pleurodesis and bullectomy provides a feasible and effective treatment option for preventing postoperative pneumothorax in patients with PSP.

scholarly journals Simultaneous Viscum pleurodesis and video-assisted thoracic surgery (VATS) bullectomy in patients with primary spontaneous pneumothorax

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hee Suk Jung ◽  
Hyun Jung Kim
Keyword(s):  
Thoracic Surgery ◽  
Spontaneous Pneumothorax ◽  
Operating Time ◽  
Viscum Album ◽  
Polyglycolic Acid ◽  
Primary Spontaneous Pneumothorax ◽  
Tube Placement ◽  
Effective Treatment Option ◽  
Video Assisted Thoracic Surgery ◽  
Video Assisted

AbstractAlthough surgery is the gold standard for treatment of primary spontaneous pneumothorax (PSP), recurrence after surgery remains a concern. This study sought to evaluate the efficacy of simultaneous pleurodesis using Viscum album (VA) extract and video-assisted thoracic surgery (VATS) bullectomy for the treatment of PSP. From March 2016 to June 2020, 175 patients with PSP underwent bullectomy and intraoperative pleurodesis with VA extract at a single institution. All operations were performed through thoracoscopy by one surgeon. Upon completion of bullectomy, a polyglycolic acid sheet was used to cover the stapler lines, and 40 mg of VA extract was instilled over the entire chest wall before chest tube placement. The median operating time was 20 min (interquartile ranges, 15–30) and the median indwelling time of chest drainage was 2 days (interquartile ranges, 2–3). There were no postoperative complications over grade 3. During the median follow-up period of 38 months (interquartile ranges, 15–48), no recurrence of pneumothorax was observed. The results of this study demonstrated that simultaneous Viscum pleurodesis and VATS bullectomy provides a feasible and effective treatment option for preventing postoperative pneumothorax in patients with PSP.

scholarly journals Familial spontaneous pneumothorax: importance of screening for Birt–Hogg–Dubé syndrome

2019 ◽  
Vol 57 (1) ◽  
pp. 39-45 ◽  
Author(s):  
Yanguo Liu ◽  
Huajie Xing ◽  
Yu Huang ◽  
Shushi Meng ◽  
Jun Wang
Keyword(s):  
Recurrence Rate ◽  
Spontaneous Pneumothorax ◽  
Clinical Characteristics ◽  
Primary Spontaneous Pneumothorax ◽  
Treatment Modalities ◽  
Onset Age ◽  
Female Ratio ◽  
The Mean ◽  
Male To Female ◽  
Bhd Syndrome

Abstract OBJECTIVES The goal of this study was to investigate the prevalence of Birt–Hogg–Dubé (BHD) syndrome in patients with familial spontaneous pneumothorax (FSP) and the clinical characteristics of pneumothorax related to BHD syndrome compared with those of primary spontaneous pneumothorax. METHODS A total of 37 families diagnosed with FSP from 2007 to 2017 were enrolled in this study. The FLCN gene, which is responsible for BHD syndrome, was sequenced using the Sanger method in 25 probands. For the patients with confirmed BHD syndrome-related pneumothorax, clinical characteristics including the median onset age of pneumothorax, the male-to-female ratio, the mean height and body mass index (BMI) and the recurrence rate after different treatment modalities were obtained and compared with those of patients with primary spontaneous pneumothorax. RESULTS Of the 25 probands with FSP, 16 [64.0%, 95% confidence interval (CI) 43.8–84.2%] harboured FLCN germline mutations. In the patients with BHD syndrome-related pneumothorax, the median onset age of pneumothorax was 34 years; the male-to-female ratio was 1.3:1; and the mean height and BMI were 167.0 ± 8.6 cm and 23.6 ± 3.4 kg/m2, respectively. These characteristics were significantly different from those in patients with primary spontaneous pneumothorax from the same centre. The recurrence rate of BHD syndrome-related pneumothorax after conservative therapy was 53.1% (95% CI 38.6–67.5%) compared with 9.1% (95% CI 0–19.4%) after surgical treatment. CONCLUSIONS BHD syndrome is one of the most common causes of FSP. Patients with FSP should be recommended for mutation screening for the FLCN gene to facilitate early diagnosis and proper intervention.

scholarly journals Simultaneous Bilateral Video-Assisted Thoracoscopic Surgery for the Treatment of Primary Spontaneous Pneumothorax

2014 ◽  
Vol 71 (3) ◽  
pp. 1703-1708 ◽  
Author(s):  
Xin Wang ◽  
Lei Wang ◽  
Huayong Wang ◽  
Hao Zhang
Keyword(s):  
Surgical Procedures ◽  
Spontaneous Pneumothorax ◽  
Thoracoscopic Surgery ◽  
Primary Spontaneous Pneumothorax ◽  
Intraoperative Bleeding ◽  
Video Assisted ◽  
Second Surgery ◽  
The Mean ◽  
Mean Time ◽  
Video Assisted Thoracoscopic Surgery

Abstract We determined the feasibility and clinical efficacy of simultaneous bilateral video-assisted thoracoscopic surgery (VATS) for treating primary spontaneous pneumothorax (PSP). We performed a retrospective analysis of the efficacy of simultaneous bilateral resection of pulmonary bullae using VATS in 21 PSP patients that were treated at our hospital from February 2010 to August 2013. We found bilateral bullae in all patients through the intraoperative exploration. Surgical procedures were successfully completed in all patients without conversion to thoracotomy. The mean time of surgery was 128.76 ± 13.82 min (range 100–150 min). Total amount of intraoperative bleeding was 80–200 ml. Total drainage of bilateral thoracic ducts was 200–500 ml at the 1st postoperative day with a mean drainage of 321.42 ± 82.66 ml. Bilateral thoracic ducts were removed 4–8 days postoperatively with a mean time of 4.7 days. The duration of postoperative hospitalization was 5–9 days with a mean duration of 7 days. No patient had serious complication(s) and all patients were discharged after full recovery. The patients were followed up for 6–18 months after the surgery and no relapse occurred. In conclusion, treating the unilateral PSP by simultaneous bilateral VATS is safe and effective. It reduces patients’ risk of second surgery and also minimizes patients’ suffering and costs incurred.

scholarly journals Hemorrhoidal artery ligation without using a doppler guide: Is it a feasible and safe technique?

2021 ◽  
Vol 62 (3) ◽  
pp. 230-235
Author(s):  
Mahmut Said Degerli ◽  
Dogan Yildirim ◽  
Mikail Cakir ◽  
Okan Murat Akturk ◽  
Orcun Alpay ◽  
...  
Keyword(s):  
Operating Time ◽  
Operation Time ◽  
Hemorrhoidal Disease ◽  
Artery Ligation ◽  
Simple Method ◽  
Hemorrhoidal Artery Ligation ◽  
Hemorrhoidal Artery ◽  
The Mean ◽  
Grade 3 ◽  
One Year

The objective of this work was to analyze the results of the hemorrhoidal artery ligation technique without using a doppler guide, in patients with grade 3 hemorrhoidal disease; by evaluating cost-effectiveness, operation time, recurrence rate, postoperative pain, and secondary outcomes. A hemorrhoidal artery ligation procedure, without using a doppler guide, was performed on 43 patients (15 females, 28 males) with grade 3 symptomatic hemorrhoidal disease, from June 2015 to June 2019, in the Haseki Training and Research Hospital, Istanbul, Turkey. Patients were followed up clinically for one month. They completed a questionnaire within one year after their procedure. The median age was 46 years (range: 24 to 82 years). The main complaints were bleeding in 27 patients, pain in 22 patients, and skin tag in 14 patients. The mean preoperative VAS score was 3.4. The mean operating time was 18 mins (range: 13 to 25 min). All patients remained hospitalized for 24 h. Reoperation was necessary for only one patient because of bleeding. One year after the surgery, the pain was resolved in 21 (95.4%) out of 22 patients with preoperative pain, and bleeding resolved in 25 (92.5%) out of 27 patients with preoperative bleeding. The hemorrhoidal artery ligation is a simple method with a shorter learning curve producing similar postoperative results to other surgical procedures. The surgical technique is cost-effective as it does not require any particular device (anoscope with Doppler ultrasound) to apply.

scholarly journals The role of telomerase in the etiology of primary spontaneous pneumothorax

2021 ◽  
Vol 29 (3) ◽  
pp. 377-383
Author(s):  
Mehmet Akif Tezcan ◽  
İbrahim Ethem Özsoy ◽  
Fatih Gürler ◽  
Çiğdem Karakükçü
Keyword(s):  
Spontaneous Pneumothorax ◽  
Telomerase Activity ◽  
Primary Spontaneous Pneumothorax ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Healthy Individuals ◽  
Genetic Studies ◽  
Thoracic Computed Tomography ◽  
The Mean

Background: This study aims to investigate the role of telomerase activity in the risk of primary spontaneous pneumothorax, which is most frequently encountered in the practice of thoracic surgery. Methods: A total of 61 patients (56 males, 5 females; median age: 29.4 years; range, 17 to 43 years) who underwent treatment for primary spontaneous pneumothorax and 19 age- and sex-matched healthy controls (10 males, 9 females; median age: 29.1 years; range, 23 to 43 years) were included in this prospective study between January 2018 - August 2018. Telomerase activity was evaluated with enzyme-linked immunosorbent assay. The correlation between telomerase activity and clinical and demographic parameters was examined. Results: The mean serum telomerase level was 3.4±0.6 ng/mL in the primary spontaneous pneumothorax group and 1.9±0.5 ng/mL in the control group, indicating significantly higher levels in the patient group (p<0.001). There was no significant association between the telomerase levels and presence of blebs and/or bullae on thoracic computed tomography, extent of pneumothorax, laterality (right, left, or bilateral), and pack years of cigarette smoking. Conclusion: Telomerase levels of patients with primary spontaneous pneumothorax are significantly higher than healthy individuals. Future genetic studies may ultimately clarify a potential relationship between primary spontaneous pneumothorax and short telomere syndrome.

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