scholarly journals Epidemiological Features for Primary Lymphoma of the Female Genital Tract Patients and Development of a Nomogram to Predict Survival

2021 ◽  
Author(s):  
Fei Peng ◽  
Jingwen Li ◽  
Shidai Mu ◽  
You Qin ◽  
Lisha Ai ◽  
...  
Keyword(s):  
Genital Tract ◽  
Cox Regression ◽  
Female Genital Tract ◽  
Risk Groups ◽  
Primary Lymphoma ◽  
Discriminative Ability ◽  
Standard Population ◽  
Ann Arbor ◽  
Optimal Accuracy ◽  
Female Genital

Abstract Background: Primary lymphoma of the female genital tract (PLFGT) is a sporadic extranodal lymphoma. Its epidemiology and prognosis are not fully recognised. Our study aimed to construct and validate prognostic nomograms for predicting survival for patients with PLFGT.Methods: Incidence rate from 1975 to 2017 and patients with PLFGT from 1975 to 2011 in the Surveillance, Epidemiology and End Results (SEER) database were retrospectively reviewed. The nomograms of OS and DSS were established according to the multivariate Cox regression analyses. The concordance index (C-index) and calibration plots were used to demonstrate its robustness and accuracy.Results: A total of 617 PLFGT patients were identified. The overall incidence of PLFGT is 0.44/1,000,000 (adjusted to the US standard population in 2000) from 1975 to 2017. Age, histological subtype, Ann Arbor Stage, and therapeutic strategy were identified as independent prognostic factors for overall survival (OS) and disease-specific survival (DSS) by multivariate Cox regression (P < 0.05). Nomograms to predict 1-, 5-, and 10- year OS and DSS were established. The C-index and calibration plots showed a good discriminative ability and an optimal accuracy of the nomograms. Patients were devided into three risk groups according to the model of OS.Conclusions: The nomograms were developed and validated as an individualized tool to predict OS and DSS.

Primary lymphoma of the female genital tract: An analysis of 697 cases

2017 ◽  
Vol 145 (2) ◽  
pp. 305-309 ◽  
Author(s):  
Dimitrios Nasioudis ◽  
Polydoros N. Kampaktsis ◽  
Melissa Frey ◽  
Steven S. Witkin ◽  
Kevin Holcomb
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
Primary Lymphoma ◽  
Female Genital

Institutional review of primary lymphoma of the female genital tract: A 32-year experience

2013 ◽  
Vol 130 (1) ◽  
pp. e152-e153
Author(s):  
A. Ahmad ◽  
J. Varughese ◽  
P. Hui ◽  
A. Santin ◽  
M. Azodi ◽  
...  
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
Primary Lymphoma ◽  
Institutional Review ◽  
Female Genital

scholarly journals Primary non-Hodgkin’s lymphoma of the vagina (PNHLV): a gynaecologist’s enigma!

2019 ◽  
Vol 12 (5) ◽  
pp. e228544 ◽  
Author(s):  
Nanak Bhagat ◽  
Pallavi Kalkur ◽  
Sanjaya Kalkur
Keyword(s):  
Abdominal Pain ◽  
Early Diagnosis ◽  
Genital Tract ◽  
Vaginal Discharge ◽  
Female Genital Tract ◽  
Vaginal Wall ◽  
Primary Lymphoma ◽  
Posterior Vaginal Wall ◽  
Appropriate Treatment ◽  
Female Genital

Primary lymphoma of the female genital tract is very rare, particularly those presenting primarily in the vagina are even rarer. We report a case of a 60-year-old woman who presented with generalised abdominal pain, vaginal discharge and a thickening of the posterior vaginal wall. Prompt radiological investigations and biopsy led to early diagnosis and appropriate treatment. Complete metabolic remission was obtained with three cycles of chemotherapy and radiotherapy. This case highlights the need for increasing the awareness about lymphomas presenting as vaginal lesion(s) and for clinicians to keep an open mind when working up such patients.

scholarly journals A Case of Primary Uterina Lymphoma Presenting with Bleeding, Pelvic Pain, and Dysmenorrhea

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Lilian Yukari Miura ◽  
Miriam Anyury Daquin Maure ◽  
Monica Tessmann Zomer ◽  
Reitan Ribeiro ◽  
Teresa Cristina Santos Cavalcanti ◽  
...  
Keyword(s):  
Pelvic Pain ◽  
Genital Tract ◽  
Transvaginal Ultrasound ◽  
Female Genital Tract ◽  
Abnormal Uterine Bleeding ◽  
Laparoscopic Hysterectomy ◽  
Primary Lymphoma ◽  
Female Population ◽  
Histologic Evaluation ◽  
Female Genital

Primary non-Hodgkin’s lymphoma (NHL) can arise from lymphatic cells located in solid organs (extranodal) and it accounts for 25 to 35% of all NHL. Primary lymphoma on the female genital tract (PLFGT) is a rare disease, comprising 0.2 to 1.1% of all extranodal lymphomas in the female population. In this paper, the authors report an extremely rare case of a 48-year-old woman who exhibited an abnormal uterine bleeding, pelvic pain, and dysmenorrhea history. The transvaginal ultrasound showed an anteverted uterus measuring 153 cm3 in volume, with intramural leiomyomas. She underwent a total laparoscopic hysterectomy with bilateral salpingectomy. The histologic evaluation of the specimen showed a follicular lymphoma with diffuse pattern in the endometrium. This report illustrates the difficulty in the diagnosis of primary lymphomas of the female genital tract.

scholarly journals A rare presentation of a patient with primary female genital lymphoma

2020 ◽  
Vol 2 (1) ◽  
pp. 18-19
Author(s):  
Emine Budak ◽  
Adnan Budak ◽  
Ayşegül Akgün ◽  
Mehmet Özeren
Keyword(s):  
Abdominal Pain ◽  
Case Report ◽  
Follicular Lymphoma ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Primary Lymphoma ◽  
Rare Presentation ◽  
Pet Ct ◽  
Histopathological Evaluation ◽  
Female Genital

Objective: Primary lymphoma originating from the female genital tract (PLFGT) is extremely rare and so we wanted to present clinical and PET / CT findings of a case with PLFGT. Case report: PET / CT images of a 57-year-old woman with abdominal pain revealed a hypermetabolic mass in the pelvic region, involving the uterus and cervix, extending to the bilateral adnexal region. Histopathological evaluation of the mass was determined as follicular lymphoma. Conclusion: Although PLFGT is extremely rare, the possibility of lymphoma should also be kept in mind in patients with gynecological mass. Keywords: extranodal lymphoma, primary lymphoma of the female genital tract, PET/CT.

Angiosarcomas of Primary Gynecologic Origin: A Clinicopathologic Review and Quantitative Analysis of Survival

2014 ◽  
Vol 24 (1) ◽  
pp. 4-12 ◽  
Author(s):  
Arnold-Jan Kruse ◽  
Simone Sep ◽  
Brigitte F.M. Slangen ◽  
Nathalie M. Vandevijver ◽  
Toon Van Gorp ◽  
...  
Keyword(s):  
Genital Tract ◽  
Cox Regression ◽  
English Literature ◽  
Female Genital Tract ◽  
Primary Treatment ◽  
Demographic Variables ◽  
Cox Regression Analysis ◽  
Kaplan Meier ◽  
Malignant Soft Tissue ◽  
Female Genital

ObjectiveAngiosarcomas are aggressive, malignant soft tissue neoplasms of endothelial origin and occur rarely in the female genital tract. There is lack of consensus on risk factors for poor outcome and optimal treatment. To this end, we performed a clinicopathologic review and survival analysis.MethodsWe report a case of a woman with an angiosarcoma of the vagina. Published English literature was reviewed for angiosarcomas of the vulva, vagina, uterus, and ovary. Survival was evaluated by using Kaplan-Meier analysis and the effect of clinical and demographic variables on survival by using Cox regression analysis.ResultsA total of 51 patients were identified with a median age of 47 years (range, 17–87 years). Two of the patients had an angiosarcoma of the vulva; 2 had an angiosarcoma of the vagina; 18 had an angiosarcoma of the uterus, and 29 had an angiosarcoma of the ovary. Five-year overall survival was 27% (SE, 8%). Most patients presented with locoregional disease, having surgery as their primary intervention. Overall, adjuvant therapy significantly improved survival (hazards ratio, 0.17; 95% confidence interval, 0.05–0.59; adjusted for age and tumor size). Adjuvant treatment consisted of radiotherapy for angiosarcomas of the vulva, vagina, and uterus and chemotherapy for ovarian angiosarcomas. Subgroup analysis of the female genital tract site was hampered by the small number of cases.ConclusionsThis review supports the use of surgical and adjuvant radiotherapy for angiosarcomas of the vulva, vagina, and uterus. Cytoreductive surgery and adjuvant chemotherapy remain the primary treatment of angiosarcomas of the ovary.

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