scholarly journals Mediating Role of Cerebellar Subregion Volume in the Relationship Between Gait Speed and Working Memory

Author(s):  
Junyeon Won ◽  
Daniel D. Callow ◽  
Jeremy J. Purcell ◽  
J. Carson Smith

Abstract Introduction: The relationship between gait speed and working memory is well-understood in older adults. However, it remains to be determined whether this relationship also exists in younger adults; and there is little known regarding the possible neural mechanism underlying the association between gait speed and working memory. The aims of this study are to determine if there is: 1) an association between gait speed and working memory performance; and 2) a mediating role of cerebellar subregion volume in the correlation between gait speed and working memory in healthy younger adults.Methods: 1054 younger adults (28.7±3.6 years) from the Human Connectome Project were included in the analyses. A four-meter gait test was used to assess gait speed. The N-back task was conducted to measure working memory performance [accuracy and response time(RT)]. T1-weighted structural MRI data (obtained using Siemens 3T MRI scanner) was used to assess cerebellar subregion volumes. Linear regression and mediation analysis were used to examine the relationships between the variables after controlling for age, sex, and education. Results: Faster gait speed was associated with faster working memory RT in younger adults. Greater cerebellar subregion volumes were associated with faster gait speed and better working memory performance. Faster gait speed was correlated with faster working memory RT through greater volume of cerebellar region VIIIa. Conclusions: The present study suggests faster gait speed is associated with faster RT during working memory tasks in younger individuals. The specific subregion of the cerebellum (VIIIa) may serve as an important neural basis linking gait speed and working memory.

2019 ◽  
Vol 91 (2) ◽  
pp. 182-197
Author(s):  
Jingjin Shao ◽  
Li Zhang ◽  
Luxia Xiao ◽  
Xiying Li ◽  
Jiamei Li

This study aims to examine the mediating role of learning self-efficacy in the relationship between subjective age and memory performance as well as the moderating role of education in these indirect and direct relationships. A study was conducted with 200 older adults aged 60 to 81 years who completed measures of subjective age, learning self-efficacy, education, and memory performance. Analysis revealed that learning self-efficacy partially mediated the association between subjective age and memory performance. Further analysis found that the indirect associations between subjective age and memory through learning self-efficacy vary as a function of education. Implications and suggestions for future research are discussed.


2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 451-451
Author(s):  
Ashley Blasi ◽  
Francesca Falzarano

Abstract Dementia Family caregivers often experience significant stress and burden, which has been associated with a myriad of adverse effects on physical and mental health, as well as cognition. The impact of caregiving on health and well-being may have negative implications on the provision of quality and effective care. Specifically, working memory is a key domain of cognition that ultimately underlies logic and decision making processes. Thus, the purpose of the current study is to examine the associations between dementia care-related stress and working memory, as well as potential mediators of this relationship, in a sample of 50 primary caregivers who completed measures examining stress, including burden and overload, and several domains of cognition. Our results showed that higher levels of caregiving overload were associated with worse working memory performance, measured using the N-back task. Additionally, we found that lower sleep quality fully mediated the relationship between overload and working memory performance, such that the negative effects of overload on working memory performance may operate as a result of sleep impairment. By determining the mediating role of sleep while also providing evidence to support the negative relationship between stress and working memory, our results provide support for the development of interventions that target factors such as burden and sleep quality to help mitigate stress in caregivers.


2017 ◽  
Vol 16 (3) ◽  
pp. 155-159 ◽  
Author(s):  
Peizhen Sun ◽  
Jennifer J. Chen ◽  
Hongyan Jiang

Abstract. This study investigated the mediating role of coping humor in the relationship between emotional intelligence (EI) and job satisfaction. Participants were 398 primary school teachers in China, who completed the Wong Law Emotional Intelligence Scale, Coping Humor Scale, and Overall Job Satisfaction Scale. Results showed that coping humor was a significant mediator between EI and job satisfaction. A further examination revealed, however, that coping humor only mediated two sub-dimensions of EI (use of emotion and regulation of emotion) and job satisfaction. Implications for future research and limitations of the study are discussed.


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