Mediating Role of Cerebellar Subregion Volume in the Relationship Between Gait Speed and Working Memory
Abstract Introduction: The relationship between gait speed and working memory is well-understood in older adults. However, it remains to be determined whether this relationship also exists in younger adults; and there is little known regarding the possible neural mechanism underlying the association between gait speed and working memory. The aims of this study are to determine if there is: 1) an association between gait speed and working memory performance; and 2) a mediating role of cerebellar subregion volume in the correlation between gait speed and working memory in healthy younger adults.Methods: 1054 younger adults (28.7±3.6 years) from the Human Connectome Project were included in the analyses. A four-meter gait test was used to assess gait speed. The N-back task was conducted to measure working memory performance [accuracy and response time(RT)]. T1-weighted structural MRI data (obtained using Siemens 3T MRI scanner) was used to assess cerebellar subregion volumes. Linear regression and mediation analysis were used to examine the relationships between the variables after controlling for age, sex, and education. Results: Faster gait speed was associated with faster working memory RT in younger adults. Greater cerebellar subregion volumes were associated with faster gait speed and better working memory performance. Faster gait speed was correlated with faster working memory RT through greater volume of cerebellar region VIIIa. Conclusions: The present study suggests faster gait speed is associated with faster RT during working memory tasks in younger individuals. The specific subregion of the cerebellum (VIIIa) may serve as an important neural basis linking gait speed and working memory.