scholarly journals Gastric Adenocarcinoma With Signet Ring Cell: A Case Report of a 10-year-old Girl.

2021 ◽  
Author(s):  
Jose Andres Tascon Arcila ◽  
Lizeth Marín Gomez ◽  
Luisa María Parra Rodas ◽  
Gustavo Giraldo Ospina ◽  
Alejandra Wilches Luna ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Genetic Counseling ◽  
Case Report ◽  
Gastric Adenocarcinoma ◽  
Pediatric Patients ◽  
Warning Signs ◽  
Palpable Mass ◽  
Signet Ring Cells ◽  
Signet Ring ◽  
Rare Diagnosis

Abstract BackgroundGastric cancer is an extremely rare diagnosis in children and adolescents. Representing 5% of neoplasia’s in childhood. Gastric adenocarcinoma has a prevalence of below 0.05% of all childhood cancers. The objective of this clinical case report is to describe the clinical presentation of this rare cancer in children, including it as a differential diagnosis, and to look for genetic causes in order to perform genetic counseling. Case presentationA 10 year old girl, experience epigastric pain, vomit and weight loss in 2 months period. Previously treated with proton pump inhibitors (PPIs), however without improvement of symptoms. Physical exam revealed a slim appearance, and a firm, painful, palpable mass in the upper abdomen. Esophagogastroduodenoscopy revealed a mass with neoplastic appearance. Biopsy report described a poorly differentiated, diffuse pattern of signet ring cells, with positive immunohistochemical studies for the expression of MLH1, MSH6; PMS2. H. pylori was negative. Because this cancer presented during childhood, CDH1 gene was analyzed, however no findings of pathologic variants, point mutations, or duplications or deletions were found. The patient underwent hospice care and died 7 months after the initial diagnosis.Discussion/ConclusionThe majority of gastric tumors during childhood are benign. Gastric adenocarcinoma is a rare diagnosis in pediatric patients. Currently, there are few reports of children with this cancer. The rarity of gastric adenocarcinoma with signet ring cells in pediatric patients makes early diagnosis difficult to make with treatment options limited to the pediatric population due to rarity, and worse prognosis. Knowledge of this disease in children could help physicians to identify atypical clinical manifestations and warning signs in order to have this as a differential diagnosis. Currently, genetic studies are essential to guide the treatment plan and to make genetic counseling to the patient and family members.

scholarly journals Polyserositis revealing a signet ring cells gastric adenocarcinoma in a 27 years old male patient: A case report.

2021 ◽  
Author(s):  
Zahid Talibi Alaoui ◽  
Salah Eddine Youbi ◽  
Fatima Ihbibane ◽  
Hind Rachidi ◽  
Fatima Ezzahra Hazmiri ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Emergency Department ◽  
Case Report ◽  
Clinical Improvement ◽  
Gastric Adenocarcinoma ◽  
Male Patient ◽  
Signet Ring Cells ◽  
Signet Ring

Abstract Gastric cancer remains one of the most common and deadly cancers worldwide, especially among old males. It is rare in the younger population (< 30 years old). We describe the case of a 27 years old male patient, presenting to the emergency department, with exsudative polyserositis, initially misdiagnosed and treated as a multifocal tuberculosis with no clinical improvement, later revealing a metastatic signet ring cells gastric adenocarcinoma.

Cytology Detects Endobronchial Metastasis from Appendiceal Signet-Ring Cell Carcinoma in the Absence of Radiographic Lung Masses: A Case Report

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S44-S44
Author(s):  
B W Taylor ◽  
K Hummel ◽  
Y Xu
Keyword(s):  
Case Report ◽  
Respiratory Distress ◽  
Cell Carcinoma ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Signet Ring Cells ◽  
Endobronchial Metastasis ◽  
Signet Ring ◽  
Ring Cell ◽  
The Right

Abstract Introduction/Objective Endobronchial metastasis (EBM) is uncommon, with a reported prevalence of 2% in cases of non-lung primary malignancies. The most frequently observed carcinomas in EBM are from breast, colon, and renal origins. We present a rare case of endobronchial metastasis from a primary tumor of the appendix without lung masses by computed tomography (CT). Methods/Case Report An 83-year-old woman with signet-ring cell carcinoma of the appendix underwent right hemicolectomy and chemotherapy. Two years later, she returned with intractable nausea and vomiting, and respiratory distress. CT of the chest demonstrated diffuse bilateral pulmonary opacities without lung masses. CT of the abdomen showed peritoneal carcinomatosis. Cytology of ascitic fluid displayed metastasis of the patient’s known appendiceal tumor. Bronchoscopy found significant friable debris appearing to be tumor tissue and occluding multiple bronchioles in the right lung. A bronchoalveolar lavage (BAL) specimen from the right lung was sent for liquid-based cytology, which revealed a few atypical cells with eccentric nuclei and intracytoplasmic vacuoles, abundant macrophages, degenerated mixed inflammatory cells, and scattered bronchial epithelial cells. Cell block demonstrated signet-ring cells mimicking macrophages and infiltrating into small fragments of bronchiolar wall. The signet-ring cells were morphologically similar to those found in the ascitic fluid and the patient’s primary tumor, and were highlighted by mucicarmine stain and immunohistochemical stains for CDX-2 and CK20, but not CK7. Results (if a Case Study enter NA) N/A Conclusion Collectively, the findings supported the diagnosis of endobronchial metastasis of signet-ring cell carcinoma from the lower gastrointestinal tract, i.e. the patient’s known appendiceal primary. Our case demonstrates a rare endobronchial metastasis of a primary neoplasm of the appendix, an important diagnostic consideration when evaluating respiratory distress in patients with such cancer histories. We have described the significant role of BAL cytology to uncover endobronchial metastases without lung masses by CT, and illustrated the finding of signet-ring cells mimicking macrophages in a BAL cytology specimen.

scholarly journals Angioleiomyoma as a rare cause of a painful subcutaneous nodule in the leg: a case report

Reumatismo ◽  
2019 ◽  
Vol 71 (2) ◽  
pp. 113-117
Author(s):  
A.A. Younis ◽  
R.A. Hamed ◽  
I.H. Abdulkareem
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Smooth Muscles ◽  
Subcutaneous Nodule ◽  
Leg Pain ◽  
Benign Tumors ◽  
Vascular Smooth Muscles ◽  
Histopathological Features ◽  
Rare Diagnosis

Angioleiomyomas are benign tumors originating in the vascular smooth muscles. The tumor typically presents as a painful, solitary, small subcutaneous nodule. Herein, we have described a case report of chronic leg pain due to angioleiomyoma. We outline the clinical, radiological and histopathological features of this rare diagnosis for a painful nodule of extremity. Although rare, angioleiomyoma should be included in the differential diagnosis of chronic leg pain.

scholarly journals Paracoccidiodomycosis lung reactivation in a patient with signet-ring cell gastric adenocarcinoma after chemotherapy: Case report

IDCases ◽  
2020 ◽  
Vol 20 ◽  
pp. e00769 ◽  
Author(s):  
F. Soto-Febres ◽  
A. Morales-Moreno ◽  
J. Arenas ◽  
G. Pérez-Lazo
Keyword(s):  
Case Report ◽  
Gastric Adenocarcinoma ◽  
Signet Ring Cell ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Primary mucinous adenocarcinoma of the bladder with signet-ring cells: case report

2007 ◽  
Vol 125 (5) ◽  
pp. 297-299 ◽  
Author(s):  
Marcelo Lorenzi Marques ◽  
Gabriel Salum D'Alessandro ◽  
Daher Cezar Chade ◽  
Valéria Pereira Lanzoni ◽  
Samuel Saiovici ◽  
...  
Keyword(s):  
Case Report ◽  
Mucinous Adenocarcinoma ◽  
Rare Case ◽  
Bladder Tumor ◽  
Colorectal Adenocarcinoma ◽  
Signet Ring Cell ◽  
Signet Ring Cells ◽  
Signet Ring ◽  
Ring Cell ◽  
Primary Bladder

CONTEXT: Primary adenocarcinomas of the bladder are uncommon and usually occur by contiguity with or hematogenic dissemination of other adenocarcinomas such as colorectal, prostate and gynecological tract carcinomas. Mucinous and signet-ring cell histological patterns are even rarer and it is often difficult to morphologically distinguish them from metastatic colorectal adenocarcinoma. CASE REPORT: We present and discuss a rare case of primary mucinous adenocarcinoma of the bladder with signet-ring cells in a 57-year-old male patient. Other primary sites for the tumor had been excluded and, in the absence of digestive tract tumor and for confirmation that it was a primary bladder tumor, an immunohistochemistry study was performed.

scholarly journals Renal leiomyoma: Case report and literature review

2013 ◽  
Vol 6 (2) ◽  
Author(s):  
Eugenio Brunocilla ◽  
Cristian Vincenzo Pultrone ◽  
Riccardo Schiavina ◽  
Valerio Vagnoni ◽  
Giacoma Caprara ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Renal Cell Carcinoma ◽  
Differential Diagnosis ◽  
Case Report ◽  
Flank Pain ◽  
Palpable Mass ◽  
Histological Features ◽  
Malignant Lesions ◽  
Benign Tumours ◽  
Radiological Examinations

Renal leiomyomas are rare benign tumours of the kidney originating from muscle cells. They are usually found by an autopsy,whether the patient is asymptomatic or has symptoms (i.e., abdominal/flank pain, hematuria, palpable mass). Today the widespread use of ultrasonography and computed tomography has increased the detection of clinically asymptomatic renal leiomyomas. The differential diagnosis between leiomyomas and other malignant lesions (above all renal cell carcinoma or leiomyosarcoma) is still possible by histological examination. Radiological examinations are not sufficient for the differential diagnosis. Renal leiomyomas have no aggressive behaviour and they usually do not metastasize. The prognosis, after surgery, is excellent without recurrence. We report a case of leiomyoma in a 31-year-old man who presented hematuria and flank pain. We also review the literature and provide a summary of clinical, radiological and histological features of renal leiomyomas.

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