Polyserositis revealing a signet ring cells gastric adenocarcinoma in a 27 years old male patient: A case report.

Abstract Gastric cancer remains one of the most common and deadly cancers worldwide, especially among old males. It is rare in the younger population (< 30 years old). We describe the case of a 27 years old male patient, presenting to the emergency department, with exsudative polyserositis, initially misdiagnosed and treated as a multifocal tuberculosis with no clinical improvement, later revealing a metastatic signet ring cells gastric adenocarcinoma.

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24-year-old Male patient Diagnosed with Intramucosal Signet Ring Cell Gastric Cancer with Molecular Analysis: A Case Report

Turkish Journal of Oncology ◽

10.5505/tjo.2019.2100 ◽

2020 ◽

Author(s):

mehtap eroğlu

Keyword(s):

Gastric Cancer ◽

Case Report ◽

Molecular Analysis ◽

Male Patient ◽

Signet Ring Cell ◽

Signet Ring ◽

Ring Cell

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Gastric Adenocarcinoma With Signet Ring Cell: A Case Report of a 10-year-old Girl.

10.21203/rs.3.rs-738601/v1 ◽

2021 ◽

Author(s):

Jose Andres Tascon Arcila ◽

Lizeth Marín Gomez ◽

Luisa María Parra Rodas ◽

Gustavo Giraldo Ospina ◽

Alejandra Wilches Luna ◽

...

Keyword(s):

Differential Diagnosis ◽

Genetic Counseling ◽

Case Report ◽

Gastric Adenocarcinoma ◽

Pediatric Patients ◽

Warning Signs ◽

Palpable Mass ◽

Signet Ring Cells ◽

Signet Ring ◽

Rare Diagnosis

Abstract BackgroundGastric cancer is an extremely rare diagnosis in children and adolescents. Representing 5% of neoplasia’s in childhood. Gastric adenocarcinoma has a prevalence of below 0.05% of all childhood cancers. The objective of this clinical case report is to describe the clinical presentation of this rare cancer in children, including it as a differential diagnosis, and to look for genetic causes in order to perform genetic counseling. Case presentationA 10 year old girl, experience epigastric pain, vomit and weight loss in 2 months period. Previously treated with proton pump inhibitors (PPIs), however without improvement of symptoms. Physical exam revealed a slim appearance, and a firm, painful, palpable mass in the upper abdomen. Esophagogastroduodenoscopy revealed a mass with neoplastic appearance. Biopsy report described a poorly differentiated, diffuse pattern of signet ring cells, with positive immunohistochemical studies for the expression of MLH1, MSH6; PMS2. H. pylori was negative. Because this cancer presented during childhood, CDH1 gene was analyzed, however no findings of pathologic variants, point mutations, or duplications or deletions were found. The patient underwent hospice care and died 7 months after the initial diagnosis.Discussion/ConclusionThe majority of gastric tumors during childhood are benign. Gastric adenocarcinoma is a rare diagnosis in pediatric patients. Currently, there are few reports of children with this cancer. The rarity of gastric adenocarcinoma with signet ring cells in pediatric patients makes early diagnosis difficult to make with treatment options limited to the pediatric population due to rarity, and worse prognosis. Knowledge of this disease in children could help physicians to identify atypical clinical manifestations and warning signs in order to have this as a differential diagnosis. Currently, genetic studies are essential to guide the treatment plan and to make genetic counseling to the patient and family members.

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Cytology Detects Endobronchial Metastasis from Appendiceal Signet-Ring Cell Carcinoma in the Absence of Radiographic Lung Masses: A Case Report

American Journal of Clinical Pathology ◽

10.1093/ajcp/aqab191.088 ◽

2021 ◽

Vol 156 (Supplement_1) ◽

pp. S44-S44

Author(s):

B W Taylor ◽

K Hummel ◽

Y Xu

Keyword(s):

Case Report ◽

Respiratory Distress ◽

Cell Carcinoma ◽

Signet Ring Cell Carcinoma ◽

Signet Ring Cell ◽

Signet Ring Cells ◽

Endobronchial Metastasis ◽

Signet Ring ◽

Ring Cell ◽

The Right

Abstract Introduction/Objective Endobronchial metastasis (EBM) is uncommon, with a reported prevalence of 2% in cases of non-lung primary malignancies. The most frequently observed carcinomas in EBM are from breast, colon, and renal origins. We present a rare case of endobronchial metastasis from a primary tumor of the appendix without lung masses by computed tomography (CT). Methods/Case Report An 83-year-old woman with signet-ring cell carcinoma of the appendix underwent right hemicolectomy and chemotherapy. Two years later, she returned with intractable nausea and vomiting, and respiratory distress. CT of the chest demonstrated diffuse bilateral pulmonary opacities without lung masses. CT of the abdomen showed peritoneal carcinomatosis. Cytology of ascitic fluid displayed metastasis of the patient’s known appendiceal tumor. Bronchoscopy found significant friable debris appearing to be tumor tissue and occluding multiple bronchioles in the right lung. A bronchoalveolar lavage (BAL) specimen from the right lung was sent for liquid-based cytology, which revealed a few atypical cells with eccentric nuclei and intracytoplasmic vacuoles, abundant macrophages, degenerated mixed inflammatory cells, and scattered bronchial epithelial cells. Cell block demonstrated signet-ring cells mimicking macrophages and infiltrating into small fragments of bronchiolar wall. The signet-ring cells were morphologically similar to those found in the ascitic fluid and the patient’s primary tumor, and were highlighted by mucicarmine stain and immunohistochemical stains for CDX-2 and CK20, but not CK7. Results (if a Case Study enter NA) N/A Conclusion Collectively, the findings supported the diagnosis of endobronchial metastasis of signet-ring cell carcinoma from the lower gastrointestinal tract, i.e. the patient’s known appendiceal primary. Our case demonstrates a rare endobronchial metastasis of a primary neoplasm of the appendix, an important diagnostic consideration when evaluating respiratory distress in patients with such cancer histories. We have described the significant role of BAL cytology to uncover endobronchial metastases without lung masses by CT, and illustrated the finding of signet-ring cells mimicking macrophages in a BAL cytology specimen.

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Mutations in Epigenetic Regulation Genes in Gastric Cancer

Cancers ◽

10.3390/cancers13184586 ◽

2021 ◽

Vol 13 (18) ◽

pp. 4586

Author(s):

Marina V. Nemtsova ◽

Alexey I. Kalinkin ◽

Ekaterina B. Kuznetsova ◽

Irina V. Bure ◽

Ekaterina A. Alekseeva ◽

...

Keyword(s):

Gastric Cancer ◽

Chromatin Remodeling ◽

Epigenetic Regulation ◽

Somatic Mutations ◽

Distant Metastases ◽

Clinical Markers ◽

Signet Ring Cells ◽

Mutational Profiling ◽

Signet Ring ◽

Epigenetic Processes

We have performed mutational profiling of 25 genes involved in epigenetic processes on 135 gastric cancer (GC) samples. In total, we identified 79 somatic mutations in 49/135 (36%) samples. The minority (n = 8) of mutations was identified in DNA methylation/demethylation genes, while the majority (n = 41), in histone modifier genes, among which mutations were most commonly found in KMT2D and KMT2C. Somatic mutations in KMT2D, KMT2C, ARID1A and CHD7 were mutually exclusive (p = 0.038). Mutations in ARID1A were associated with distant metastases (p = 0.03). The overall survival of patients in the group with metastases and in the group with tumors with signet ring cells was significantly reduced in the presence of mutations in epigenetic regulation genes (p = 0.036 and p = 0.041, respectively). Separately, somatic mutations in chromatin remodeling genes correlate with low survival rate of patients without distant metastasis (p = 0.045) and in the presence of signet ring cells (p = 0.0014). Our results suggest that mutations in epigenetic regulation genes may be valuable clinical markers and deserve further exploration in independent cohorts.

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