scholarly journals Delayed Cerebellar Injury is Affected by Multiple Organ Dysfunction Syndrome Caused by Heat Stroke, a Retrospective Cohort Study

2021 ◽  
Author(s):  
Xiao-xiao Ni ◽  
Cong-lin Wang ◽  
Jie Wang ◽  
Ye-qun Guo ◽  
Yan Chen ◽  
...  
Keyword(s):  
Nerve Injury ◽  
Heat Stroke ◽  
Multiple Organ ◽  
The Other ◽  
Multiple Organ Dysfunction ◽  
Nerve Injuries ◽  
Injury Group ◽  
Liver And Kidney ◽  
Cerebellar Injury ◽  
Coagulation Dysfunction

Abstract Objective Nervous dysfunction is the main manifestation of heat stroke (HS). Here we investigated the clinical signs for HS-induced nerve injuries. Methods Retrospective data were collected on 119 patients who got HS from 2016 to 2020. Patients were divided into 4 groups, including the cerebellar injury group, the other nerve injuries group, non-cerebellar injury group and non-nerve injury group. The age, body temperature (Tc), degree of consciousness disorder, liver and kidney function, blood coagulation function, blood routine and cardiac indicators within 24 h after HS were summarized. Moreover, we performed regression analyses to identify risk factors for nervous dysfunction. The Activity of Daily Living (ADL) score was assessed 3 months after HS to evaluate the prognosis of HS. Results Compared with other groups, the cerebellar injury group had shorter Tc recovering time, lower GSC scales, longer coma time and more hypotension, gastrointestinal bleeding, multiple organ dysfunction syndrome (MODS) and metabolic acidosis significantly. The cerebellar injury group had higher myocardial enzymogram and indexes of liver and kidney dysfunction, immune and coagulation dysfunction significantly. Risk factors associated with HS-induced cerebellar injury are Tc, recovery time of Tc, NSE, GCS scale, lymphocyte count, HLA-DR/CD14, coagulation dysfunction, cardiac injury, metabolic acidosis and MODS. The ADL scale of the cerebellar injury group and the other nerve injury group were significantly lower than other groups. Conclusions Patients with severe coma and MODS are more prone to cerebellar injury after HS and the HS-induced nerve injury leaded to a worse prognosis.

scholarly journals Risk of lingual nerve injuries in removal of mandibular third molars: a retrospective case-control study

2019 ◽  
Vol 41 (1) ◽  
Author(s):  
Itaru Tojyo ◽  
Takashi Nakanishi ◽  
Yukari Shintani ◽  
Kenjiro Okamoto ◽  
Yukihiro Hiraishi ◽  
...  
Keyword(s):  
Nerve Injury ◽  
Third Molar ◽  
Lingual Nerve ◽  
Control Group ◽  
Nerve Injuries ◽  
Control Groups ◽  
Injury Group ◽  
Mandibular Third Molar ◽  
Mandibular Third Molars ◽  
Lingual Nerve Injuries

Abstract Background Through the analysis of clinical data, we attempted to investigate the etiology and determine the risk of severe iatrogenic lingual nerve injuries in the removal of the mandibular third molar. Methods A retrospective chart review was performed for patients who had undergone microsurgical repair of lingual nerve injuries. The following data were collected and analyzed: patient sex, age, nerve injury side, type of impaction (Winter’s classification, Pell and Gregory’s classification). Ratios for the respective lingual nerve injury group data were compared with the ratios of the respective data for the control group, which consisted of data collected from the literature. The data for the control group included previous patients that encountered various complications during the removal of the mandibular third molar. Results The lingual nerve injury group consisted of 24 males and 58 females. The rate of female patients with iatrogenic lingual nerve injuries was significantly higher than the control groups. Ages ranged from 15 to 67 years, with a mean age of 36.5 years old. Lingual nerve injury was significantly higher in the patient versus the control groups in age. The lingual nerve injury was on the right side in 46 and on the left side in 36 patients. There was no significant difference for the injury side. The distoangular and horizontal ratios were the highest in our lingual nerve injury group. The distoangular impaction rate in our lingual nerve injury group was significantly higher than the rate for the control groups. Conclusion Distoangular impaction of the mandibular third molar in female patients in their 30s, 40s, and 50s may be a higher risk factor of severe lingual nerve injury in the removal of mandibular third molars.

Successful management of heat stroke associated with multiple-organ dysfunction by active intravascular cooling

2015 ◽  
Vol 33 (1) ◽  
pp. 124.e5-124.e7 ◽  
Author(s):  
Hideyuki Hamaya ◽  
Toru Hifumi ◽  
Kenya Kawakita ◽  
Tomoya Okazaki ◽  
Kazutaka Kiridume ◽  
...  
Keyword(s):  
Organ Dysfunction ◽  
Heat Stroke ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Successful Management

scholarly journals SRIS and SDOM Constructs Associated with Sepsis

2018 ◽  
Vol 3 (4) ◽  
pp. 997-1002
Author(s):  
Carlos Manterola
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Acute Cholangitis ◽  
Multiple Organ ◽  
The Other ◽  
Multiple Organ Dysfunction ◽  
Organ Function ◽  
Infectious Origin ◽  
Inflammatory Activation ◽  
Critical Organ

Sepsis is a systemic inflammatory response syndrome (SIRS) that is triggered by infection. On the other hand, multiple organ dysfunction syndrome (MODS) is the failure of critical organ function in patients suffering from SIRS. Because SIRS and SDOM are consequences of excessive inflammatory activation. The aim of this article is to provide a review of some pathophysiological aspects of the SRIS / SDOM construct of infectious origin, using the acute cholangitis as an example of this chain of events.

Analysis of nutritional support in a case of heat stroke complicated with multiple organ dysfunction syndrome

2019 ◽  
Vol 19 (6) ◽  
pp. 428-433
Author(s):  
Yan FEI ◽  
Yunchen ZHANG ◽  
Zhimin CHEN ◽  
Chengjia DAI ◽  
Huizhen GAN ◽  
...  
Keyword(s):  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Nutritional Support ◽  
Heat Stroke ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction

scholarly journals Melatonin Improves Outcomes of Heatstroke in Mice by Reducing Brain Inflammation and Oxidative Damage and Multiple Organ Dysfunction

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Yu-Feng Tian ◽  
Cheng-Hsien Lin ◽  
Shu-Fen Hsu ◽  
Mao-Tsun Lin
Keyword(s):  
Heat Stress ◽  
Oxidative Damage ◽  
Organ Dysfunction ◽  
Heat Stroke ◽  
Multiple Organ ◽  
Brain Inflammation ◽  
Multiple Organ Dysfunction ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis

We report here that when untreated mice underwent heat stress, they displayed thermoregulatory deficit (e.g., animals display hypothermia during room temperature exposure), brain (or hypothalamic) inflammation, ischemia, oxidative damage, hypothalamic-pituitary-adrenal axis impairment (e.g., decreased plasma levels of both adrenocorticotrophic hormone and corticosterone during heat stress), multiple organ dysfunction or failure, and lethality. Melatonin therapy significantly reduced the thermoregulatory deficit, brain inflammation, ischemia, oxidative damage, hypothalamic-pituitary-adrenal axis impairment, multiple organ dysfunction, and lethality caused by heat stroke. Our data indicate that melatonin may improve outcomes of heat stroke by reducing brain inflammation, oxidative damage, and multiple organ dysfunction.

Disseminated intravascular coagulation in meningococcal sepsis

2003 ◽  
Vol 23 (03) ◽  
pp. 125-130 ◽  
Author(s):  
S. Zeerleder ◽  
R. Zürcher Zenklusen ◽  
C. E. Hack ◽  
W. A. Wuillemin
Keyword(s):  
Organ Dysfunction ◽  
Disseminated Intravascular Coagulation ◽  
Skin Necrosis ◽  
Multiple Organ ◽  
Meningococcal Sepsis ◽  
Multiple Organ Dysfunction ◽  
Intravascular Coagulation ◽  
Therapeutic Concepts ◽  
New Therapeutic Concepts ◽  
Coagulation And Fibrinolysis

SummaryWe report on a man (age: 49 years), who died from severe meningococcal sepsis with disseminated intravascular coagulation (DIC), multiple organ dysfunction syndrome and extended skin necrosis. We discuss in detail the pathophysiology of the activation of coagulation and fibrinolysis during sepsis. The article discusses new therapeutic concepts in the treatment of disseminated intravascular coagulation in meningococcal sepsis, too.

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