Comparison between 5-aminolevulinic acid photodynamic diagnosis and narrow-band imaging for bladder cancer detection

Abstract Background To compare 5-aminolevulinic acid (5-ALA)-mediated photodynamic diagnosis (PDD) with narrow-band imaging (NBI) for cancer detection during transurethral resection of bladder tumour (TURBT). Methods Between June 2018 and October 2020, 114 patients and 282 lesions were included in the analysis. Patients were orally administered 5-ALA (20 mg/kg) 2 h before TURBT. The bladder was inspected with white light (WL), PDD, and NBI for each patient, and all areas positive by at least one method were resected or biopsied. The imaging data were then compared to the pathology results. Results The sensitivities of WL, PDD, and NBI for detecting urothelial carcinoma were 88.1%, 89.6%, and 76.2%, respectively. The specificity, positive predictive value, and negative predictive value for detecting urothelial carcinoma were 47.5%, 80.9%, and 61.3%, respectively, for WL; 22.5%, 74.5%, and 46.2%, respectively, for PDD; and 46.3%, 78.2%, and 43.5%, respectively, for NBI. PDD was significantly more sensitive than NBI for all lesions (p < 0.001) and carcinoma in situ (CIS) lesions (94.6% vs. 54.1%, p < 0.001). Conclusions PDD can increase the detection rate of bladder cancer, compared to NBI, by greater than 10%. Therefore, 100% of CIS lesions can be detected by adding PDD to WL.

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Comparison Between 5-Aminolevulinic Acid Photodynamic Diagnosis and Narrow- Band Imaging for Bladder Cancer Detection: A Single-Center Retrospective Cohort Study

10.21203/rs.3.rs-767864/v1 ◽

2021 ◽

Author(s):

Hiroki Hagimoto ◽

Noriyuki Makita ◽

Yuta Mine ◽

Hidetoshi Kokubun ◽

Shiori Murata ◽

...

Keyword(s):

Bladder Cancer ◽

Cancer Detection ◽

White Light ◽

Transurethral Resection ◽

Aminolevulinic Acid ◽

Narrow Band ◽

Narrow Band Imaging ◽

Photodynamic Diagnosis ◽

Bladder Tumors

Abstract BackgroundNo comparative studies exist between 5-aminolevulinic acid-photodynamic diagnosis (PDD) and narrow-band imaging (NBI) for the detection of urothelial carcinoma. Therefore, we compared 5-aminolevulinic acid-mediated PDD with NBI for cancer detection during transurethral resection of bladder tumors.MethodsBetween June 2018 and October 2020, 114 patients and 282 lesions were included in the analysis. Patients were orally administered 5-aminolevulinic acid (20 mg/kg) 2 h before transurethral resection of bladder tumors. The bladder was inspected with white light, PDD, and NBI for each patient and all areas that were positive by at least one method were resected or biopsied. The imaging data were then compared to the pathology results.ResultsThe sensitivity, specificity, positive predictive value, and negative predictive value for detecting urothelial carcinoma were 88.1%, 47.5%, 80.9%, and 61.3% for white light; 89.6%, 22.5%, 74.5%, and 46.2% for PDD; and 76.2%, 46.3%, 78.2%, and 43.5% for NBI, respectively. PPD was significantly more sensitive than NBI for all lesions (p<0.001), including carcinoma in situ lesions (94.6% vs. 54.1%, p<0.001).ConclusionsPDD can increase the detection rate of bladder cancer compared to NBI by greater than 10%. Adding PDD to white light can detect 100% of carcinoma in situ lesions.

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Diagnostic accuracy of photodynamic diagnosis with 5-aminolevulinic acid, hexaminolevulinate and narrow band imaging for non-muscle invasive bladder cancer

Journal of Cancer ◽

10.7150/jca.34527 ◽

2020 ◽

Vol 11 (5) ◽

pp. 1082-1093 ◽

Cited By ~ 1

Author(s):

Changhao Chen ◽

Hao Huang ◽

Yue Zhao ◽

Hao Liu ◽

Yuming Luo ◽

...

Keyword(s):

Bladder Cancer ◽

Diagnostic Accuracy ◽

Aminolevulinic Acid ◽

Narrow Band ◽

Narrow Band Imaging ◽

Invasive Bladder Cancer ◽

Photodynamic Diagnosis ◽

Muscle Invasive Bladder Cancer ◽

Muscle Invasive

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Emerging Endoscopic and Photodynamic Techniques for Bladder Cancer Detection and Surveillance

The Scientific World JOURNAL ◽

10.1100/2011/412739 ◽

2011 ◽

Vol 11 ◽

pp. 2550-2558 ◽

Cited By ~ 11

Author(s):

Prashant Patel ◽

Richard T. Bryan ◽

D. Michael A. Wallace

Keyword(s):

Raman Spectroscopy ◽

Bladder Cancer ◽

Cancer Detection ◽

Clinical Evidence ◽

Narrow Band ◽

Narrow Band Imaging ◽

Photodynamic Diagnosis ◽

Virtual Cystoscopy ◽

Spectroscopy Optical ◽

Bladder Tumours

This review provides an overview of emerging techniques, namely, photodynamic diagnosis (PDD), narrow band imaging (NBI), Raman spectroscopy, optical coherence tomography, virtual cystoscopy, and endoscopic microscopy for its use in the diagnosis and surveillance of bladder cancer. The technology, clinical evidence and future applications of these approaches are discussed with particular emphasis on PDD and NBI. These approaches show promise to optimise cystoscopy and transurethral resection of bladder tumours.

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Performance of Narrow Band Imaging (NBI) and Photodynamic Diagnosis (PDD) Fluorescence Imaging Compared to White Light Cystoscopy (WLC) in Detecting Non-Muscle Invasive Bladder Cancer: A Systematic Review and Lesion-Level Diagnostic Meta-Analysis

Cancers ◽

10.3390/cancers13174378 ◽

2021 ◽

Vol 13 (17) ◽

pp. 4378

Author(s):

Giorgio I. Russo ◽

Tamir N. Sholklapper ◽

Andrea Cocci ◽

Giuseppe Broggi ◽

Rosario Caltabiano ◽

...

Keyword(s):

Systematic Review ◽

Bladder Cancer ◽

White Light ◽

Narrow Band ◽

Narrow Band Imaging ◽

Meta Analysis ◽

Photodynamic Diagnosis ◽

Muscle Invasive Bladder Cancer ◽

White Light Cystoscopy ◽

Muscle Invasive

Despite early detection and regular surveillance of non-muscle invasive bladder cancer (NMIBC), recurrence and progression rates remain exceedingly high for this highly prevalent malignancy. Limited visualization of malignant lesions with standard cystoscopy and associated false-negative biopsy rates have been the driving force for investigating alternative and adjunctive technologies for improved cystoscopy. The aim of our systematic review and meta-analysis was to compare the sensitivity, specificity, and oncologic outcomes of photodynamic diagnosis (PDD) fluorescence, narrow band imaging (NBI), and conventional white light cystoscopy (WLC) in detecting NMIBC. Out of 1,087 studies reviewed, 17 prospective non-randomized and randomized controlled trials met inclusion criteria for the study. We demonstrated that tumor resection with either PDD and NBI exhibited lower recurrence rates and greater diagnostic sensitivity compared to WLC alone. NBI demonstrated superior disease sensitivity and specificity as compared to WLC and an overall greater hierarchical summary receiver operative characteristic. Our findings are consistent with emerging guidelines and underscore the value of integrating these enhanced technologies as a part of the standard care for patients with suspected or confirmed NMIBC.

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The Clinical Research Office of the Endourological Society (CROES) Multicentre Randomised Trial of Narrow Band Imaging–Assisted Transurethral Resection of Bladder Tumour (TURBT) Versus Conventional White Light Imaging–Assisted TURBT in Primary Non–Muscle-invasive Bladder Cancer Patients: Trial Protocol and 1-year Results

European Urology ◽

10.1016/j.eururo.2016.03.053 ◽

2016 ◽

Vol 70 (3) ◽

pp. 506-515 ◽

Cited By ~ 64

Author(s):

Seiji Naito ◽

Ferran Algaba ◽

Marko Babjuk ◽

Richard T. Bryan ◽

Ying-Hao Sun ◽

...

Keyword(s):

Bladder Cancer ◽

Narrow Band ◽

Narrow Band Imaging ◽

Bladder Tumour ◽

Randomised Trial ◽

Trial Protocol ◽

Muscle Invasive Bladder Cancer ◽

Muscle Invasive ◽

White Light Imaging ◽

Research Office

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Narrow band imaging (NBI) cystoscopy and assisted bipolar TURBT: A preliminary experience in a single centre

Archivio Italiano di Urologia e Andrologia ◽

10.4081/aiua.2017.3.232 ◽

2017 ◽

Vol 89 (3) ◽

pp. 232 ◽

Cited By ~ 1

Author(s):

Roberto Giulianelli ◽

Barbara Cristina Gentile ◽

Luca Albanesi ◽

Paola Tariciotti ◽

Gabriella Mirabile

Keyword(s):

Bladder Cancer ◽

Predictive Power ◽

Narrow Band ◽

Narrow Band Imaging ◽

Bladder Tumour ◽

Histological Evaluation ◽

White Light Cystoscopy ◽

Secondary Objective ◽

Suspicious Lesions

Objective: The aim of this study was to compare, in order to increase our ability to detect bladder cancer, the predictive power of narrow band imaging (NBI) versus white light cystoscopy (WL). The secondary objective was to evaluate how the preoperative use of NBI cystoscopy can increase the ability to detect bladder lesions in terms of status, multi-focality and dimensions. Materials and methods: Between June 2010 and April 2012, 797 consecutive patients, 423 male and 374 female, affected by suspected bladder cancer lesions, underwent to WL plus NBI cystoscopy and subsequently to WL Bipolar Gyrus PK (Olympus, Tokyo, Japan) transurethral resection of bladder tumour (WL-TURBT). The average follow-up was 24 (16-38) months. Mean age was 67.7 yrs. (range 46-88). All the patients underwent by same surgeon to WL resection (WL-TURBT) of the previously identified lesions by same surgeon. All the removed tissue was sent separately for histological evaluation after mapping the areas of resection on a topographic sheet. Results: In our study we considered 797 patients that matched our inclusion criteria. Through the use of WL cystoscopy, we identified 603 patients (75.53%) with suspicious lesions, instead, with the use of light NBI, we found 786 patients with suspicious lesions (98.49%).The use of NBI cystoscopy increases by approximately 30% the specific ability to detect lesions not otherwise visible with WL cystoscopy (OR 21.9 and RR 1.30), in particular for patients with lesions size < 3 cm (OR 24.00; RR 1.40), unifocal (OR: 22.28; RR 1.47) and recurrent (OR 58.4; RR 1.34). Pathology demonstrated the presence of cancer in 512 (64.2%) patients, of whom 412 (51.8%) were visible both with WL cystoscopy and NBI cystoscopy. In our experience, only 11 (1.38%) lesions were only positive at WL cystoscopy (negative at NBI cystoscopy) thus 501 (62.8%, OR 10.13; RR 1.21) patients showed bladder oncological lesions positive at NBI cystoscopy. In these patients, the use the NBI Cystoscopy has better highlighted a recurrence (p < 0.005; OR 22.8, RR 1.23; 95% CI-1.13 to 0.24) or a lesion < 3 cm (p < 0.05; OR 11.4 , RR 1.30; 95% CI-0.18 to 0.29) or a unifocal lesion (p < 0.005; OR 10.38, RR 1.34, CI 0.18 to 0.30). Conclusions: The use of NBI cystoscopy, significantly increases by approximately 30% our predictive power to identify neoplastic lesions, especially unifocal or < 3 cm or recurrent lesions. Following WLTURBT, stage, dimension and focaliity are statistically significant determinants (p < 0.001) of the bladder oncological lesions detected by NBI cystoscopy rather than by WL cystoscopy.

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