scholarly journals CD8-positive Indolent T-Cell Lymphoproliferative Disorder of the Gastrointestinal Tract: Case Report and Literature Review.

2021 ◽  
Author(s):  
Meng Li ◽  
Chun-Yan Weng ◽  
Cheng Ye ◽  
Yi-Hong Fan ◽  
Bin Lu ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
T Cell ◽  
Lymphoproliferative Disorder ◽  
Target Identification ◽  
Histopathological Analysis ◽  
Epigenetic Alterations ◽  
Future Directions ◽  
History Of ◽  
Specific Symptoms ◽  
Hematoxylin Eosin

Abstract Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract (ITLPD-GI), a primary tumor forming in the GI tract, represents a rarely diagnosed clonal T-cell disease with a protracted clinical course. This report presents a 45-year-old male patient with a 6-year history of anal fistula and a more than 10-year history of recurrent diarrhea, who was not rightly diagnosed until the occurrence of complications such as intestinal perforation. Postsurgical histopathological analysis confirmed the diagnosis of CD8+ ITLPD-GI, with a combination of hematoxylin-eosin staining (H&E) staining, immunohistochemistry (IHC) and TCRβ/γ clonal gene rearrangement. Individuals with this scarce lymphoma frequently show non-specific symptoms, which are hardly recognized. So far, indolent CD8+ ITLPD-GI has not been comprehensively examined. The current mini-review focused on available reports evaluating indolent CD8+ ITLPD-GI cases, discussing future directions for improved differential diagnosis, genetic and epigenetic alterations, and therapeutic target identification.

scholarly journals Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract managed conservatively with corticosteroids

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Tyler McKechnie ◽  
Haroon Yousuf ◽  
Stephen Somerton
Keyword(s):  
Computed Tomography ◽  
Weight Loss ◽  
Abdominal Pain ◽  
Gastrointestinal Tract ◽  
T Cell ◽  
Complete Resolution ◽  
Lymphoproliferative Disorder ◽  
Duodenal Biopsy ◽  
High Dose ◽  
History Of

An 82-year-old female presented with a 4-week history of abdominal pain, weight loss, diarrhea, and nausea. A complete infectious workup was negative. Her computed tomography (CT) scan showed no pathologic changes and her esophagogastroduodenoscopy (EGD) showed erosive damage in the duodenum. Her duodenal biopsy showed inflammation with a marked increase in intra-epithelial lymphocytes and her immunohistochemistry was consistent with indolent T-cell lymphoproliferative disorder of the gastrointestinal tract. She was started on high dose steroids three months after the onset of her symptoms. She gradually improved with complete resolution of erosive changes on her repeat EGD.

Indolent T-Cell Lymphoproliferative Disorder of the Gastrointestinal Tract

2017 ◽  
Vol 112 ◽  
pp. S652-S653 ◽  
Author(s):  
Ayush Sharma ◽  
Nora N. Bennani ◽  
Andrew Feldman ◽  
Joseph A. Murray
Keyword(s):  
Gastrointestinal Tract ◽  
T Cell ◽  
Lymphoproliferative Disorder

scholarly journals Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract: a tricky diagnosis of a gastric case

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Magda Zanelli ◽  
Maurizio Zizzo ◽  
Francesca Sanguedolce ◽  
Giovanni Martino ◽  
Alessandra Soriano ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Gastrointestinal Tract ◽  
T Cell ◽  
Small Bowel ◽  
T Cell Receptor ◽  
Molecular Analysis ◽  
Lymphoproliferative Disorder ◽  
Cell Receptor ◽  
World Health ◽  
Gastric Biopsies

Abstract Background Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract is a rare low-grade clonal lymphoid proliferation, included as a provisional entity in the current World Health Organization classification. The disease is generally localized to the gastrointestinal tract, mainly small bowel and colon. Involvement of other organs is infrequently reported. The majority of patients show a protracted clinical course with persistent disease. A prolonged survival, even without treatment, is common. Case presentation A 28-year-old woman had a 2-year history of dyspepsia and lactose intolerance. Autoimmune diseases and celiac disease were excluded. No gross lesions were identified by endoscopy. Multiple gastric biopsies showed a small-sized lymphoid infiltrate, expanding the lamina propria, with a non-destructive appearance. The lymphoid cells were positive for CD3, CD4, CD5, CD7 and negative for CD20, CD8, CD56, CD103, PD1, CD30, ALK1, CD10, BCL6, perforin, TIA-1, Granzyme B and Epstein-Barr virus-encoded RNA. KI-67 index was low (5%). Molecular analysis revealed a clonal T-cell receptor γ rearrangement. Bone marrow was microscopically free of disease, but molecular testing identified the same T-cell receptor γ rearrangement present in the gastric biopsies. After the diagnosis of indolent T-cell lymphoproliferative disorder of the gastrointestinal tract, the patient received steroid therapy, only for 2 months. She is alive, with a stable disease restricted to the stomach, at 12 months from diagnosis. Conclusions Indolent T-cell lymphoproliferative disorder is usually a disease of adulthood (median age: 51 yrs). The small bowel and colon are the sites most commonly involved. Our case occurred in a young woman and affected the stomach, sparing small intestine and colon. Clonality testing identified involvement of bone marrow, a site infrequently affected in this disease. Our aim is focusing on the main diagnostic issues. If appropriate immunostainings and molecular analysis are not performed, the subtle infiltrate may be easily overlooked. The risk of misdiagnosis as more aggressive lymphomas, causing patient overtreatment, needs also to be considered.

Oral manifestation of indolent T‐cell lymphoproliferative disorder of the gastrointestinal tract: A potential diagnostic pitfall

2020 ◽  
Vol 47 (5) ◽  
pp. 494-496
Author(s):  
Andrea Saggini ◽  
Francesca Baciorri ◽  
Monia Di Prete ◽  
Anna Giulia Zizzari ◽  
Lucia Anemona
Keyword(s):  
Gastrointestinal Tract ◽  
T Cell ◽  
Lymphoproliferative Disorder ◽  
Oral Manifestation ◽  
Diagnostic Pitfall

scholarly journals Liver abscess in the caudate lobe caused by a fishbone and treated by laparoscopy: a case report

BMC Surgery ◽  
2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Feng Xia ◽  
Peng Zhu ◽  
Xiao-ping Chen ◽  
Bi-xiang Zhang ◽  
Ming-yu Zhang
Keyword(s):  
Gastrointestinal Tract ◽  
Liver Abscess ◽  
Foreign Bodies ◽  
Multidisciplinary Treatment ◽  
Caudate Lobe ◽  
Abscess Formation ◽  
Contrast Enhanced ◽  
History Of ◽  
Specific Symptoms ◽  
Inflammatory Changes

Abstract Background Ingestion of fish bones leading to gastric perforation and inducing abscess formation in the caudate lobe of the liver is very rare. Case presentation A 67-year-old man presented to our hospital with a 2-day history of subxiphoid pain. There were no specific symptoms other than pain. Laboratory tests showed only an increase in the number and percentage of neutrophils. Contrast-enhanced Computerized tomography (CT) of the abdomen showed two linear dense opacities in the gastric cardia, one of which penetrated the stomach and was adjacent to the caudate lobe of the liver, with inflammatory changes in the caudate lobe. We finally diagnosed his condition as a caudate lobe abscess secondary to intestinal perforation caused by a fishbone based on the history and imaging findings. The patient underwent 3D laparoscopic partial caudate lobectomy, incision and drainage of the liver abscess, and fishbone removal. The procedure was successful and we removed the fishbone from the liver. The patient was discharged on the 9th postoperative day without other complications. Conclusions Liver abscess caused by foreign bodies requires multidisciplinary treatment. Especially when located in the caudate lobe, we must detect and remove the cause of the abscess as early as possible. Foreign bodies that perforate the gastrointestinal tract can penetrate to the liver and cause abscess formation, as in this case. When exploring the etiology of liver abscesses, we should investigate the general condition, including the whole gastrointestinal tract.

scholarly journals Recurrent STAT3-JAK2 fusions in indolent T-cell lymphoproliferative disorder of the gastrointestinal tract

Blood ◽  
2018 ◽  
Vol 131 (20) ◽  
pp. 2262-2266 ◽  
Author(s):  
Ayush Sharma ◽  
Naoki Oishi ◽  
Rebecca L. Boddicker ◽  
Guangzhen Hu ◽  
Hailey K. Benson ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
T Cell ◽  
Lymphoproliferative Disorder
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