scholarly journals Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract managed conservatively with corticosteroids

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Tyler McKechnie ◽  
Haroon Yousuf ◽  
Stephen Somerton
Keyword(s):  
Computed Tomography ◽  
Weight Loss ◽  
Abdominal Pain ◽  
Gastrointestinal Tract ◽  
T Cell ◽  
Complete Resolution ◽  
Lymphoproliferative Disorder ◽  
Duodenal Biopsy ◽  
High Dose ◽  
History Of

An 82-year-old female presented with a 4-week history of abdominal pain, weight loss, diarrhea, and nausea. A complete infectious workup was negative. Her computed tomography (CT) scan showed no pathologic changes and her esophagogastroduodenoscopy (EGD) showed erosive damage in the duodenum. Her duodenal biopsy showed inflammation with a marked increase in intra-epithelial lymphocytes and her immunohistochemistry was consistent with indolent T-cell lymphoproliferative disorder of the gastrointestinal tract. She was started on high dose steroids three months after the onset of her symptoms. She gradually improved with complete resolution of erosive changes on her repeat EGD.

scholarly journals CD8-positive Indolent T-Cell Lymphoproliferative Disorder of the Gastrointestinal Tract: Case Report and Literature Review.

2021 ◽  
Author(s):  
Meng Li ◽  
Chun-Yan Weng ◽  
Cheng Ye ◽  
Yi-Hong Fan ◽  
Bin Lu ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
T Cell ◽  
Lymphoproliferative Disorder ◽  
Target Identification ◽  
Histopathological Analysis ◽  
Epigenetic Alterations ◽  
Future Directions ◽  
History Of ◽  
Specific Symptoms ◽  
Hematoxylin Eosin

Abstract Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract (ITLPD-GI), a primary tumor forming in the GI tract, represents a rarely diagnosed clonal T-cell disease with a protracted clinical course. This report presents a 45-year-old male patient with a 6-year history of anal fistula and a more than 10-year history of recurrent diarrhea, who was not rightly diagnosed until the occurrence of complications such as intestinal perforation. Postsurgical histopathological analysis confirmed the diagnosis of CD8+ ITLPD-GI, with a combination of hematoxylin-eosin staining (H&E) staining, immunohistochemistry (IHC) and TCRβ/γ clonal gene rearrangement. Individuals with this scarce lymphoma frequently show non-specific symptoms, which are hardly recognized. So far, indolent CD8+ ITLPD-GI has not been comprehensively examined. The current mini-review focused on available reports evaluating indolent CD8+ ITLPD-GI cases, discussing future directions for improved differential diagnosis, genetic and epigenetic alterations, and therapeutic target identification.

scholarly journals Unusual case of Giardia lamblia causing eosinophilic ascites along with Plesiomonasshigelloides gastroenteritis

Biomedicine ◽  
2021 ◽  
Vol 41 (2) ◽  
pp. 321-323
Author(s):  
Ballal Mamatha ◽  
Shetty Vignesh ◽  
Agarwal Manali ◽  
Nayal Bhavna ◽  
Umakanth Shashikiran
Keyword(s):  
Abdominal Pain ◽  
Case Report ◽  
Giardia Lamblia ◽  
Complete Resolution ◽  
Unusual Case ◽  
Peripheral Eosinophilia ◽  
Short Trip ◽  
Eosinophilic Ascites ◽  
History Of

A case report of a healthy, immunocompetent male,an international traveller from Germany who had visited India for a short trip,presented at our OPD with a history of loose stools, fever and abdominal pain,for two months. After thorough investigations, he was diagnosed to have an infection withGiardia lambliaacute gastroenteritis (AGE) along witheosinophilic ascites with peripheral eosinophilia, withassociatedPlesiomonasshigelloidesdiarrhoea. He was then treated with metronidazole and cotrimoxazole, which resulted in complete resolution of the symptoms.

scholarly journals Computed Tomography Imaging in Lemmel Syndrome: A Report of Two Cases

2019 ◽  
Vol 9 ◽  
pp. 23
Author(s):  
Giulia Frauenfelder ◽  
Annamaria Maraziti ◽  
Vincenzo Ciccone ◽  
Giuliano Maraziti ◽  
Oliviero Caleo ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Abdominal Pain ◽  
Bile Duct ◽  
Common Bile Duct ◽  
Acute Abdominal Pain ◽  
Imaging Modality ◽  
Biliary Duct ◽  
History Of ◽  
The Common ◽  
Solid Lesions

Lemmel syndrome is a rare and misdiagnosed cause of acute abdominal pain due to a juxtapapillary duodenal diverticulum causing mechanical obstruction of the common bile duct. Frequently, patients suffering from Lemmel syndrome have a history of recurrent access to the emergency room for acute abdominal pain referable to a biliopancreatic obstruction, in the absence of lithiasis nuclei or solid lesions at radiological examinations. Ultrasonography (US) may be helpful in evaluation of upstream dilatation of extra-/intra-hepatic biliary duct, but computed tomography (CT) is the reference imaging modality for the diagnosis of periampullary duodenal diverticula compressing the intrapancreatic portion of the common bile duct. Recognition of this entity is crucial for targeted, timely therapy avoiding mismanagement and therapeutic delay. The aim of this paper is to report CT imaging findings and our experience in two patients affected by Lemmel syndrome.

scholarly journals Actinomyces graevenitziiPulmonary Abscess Mimicking Tuberculosis in a Healthy Young Man

2014 ◽  
Vol 21 (6) ◽  
pp. e75-e77 ◽  
Author(s):  
Smaranda Gliga ◽  
Mathilde Devaux ◽  
Marine Gosset Woimant ◽  
Dominique Mompoint ◽  
Christian Perronne ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Clinical Samples ◽  
High Dose ◽  
Pulmonary Actinomycosis ◽  
History Of ◽  
Right Lobe

Pulmonary actinomycosis is a rare disease that is often misdiag-nosed as tuberculosis or lung cancer.Actinomyces graevenitziiis a relatively new recognizedActinomycesspecies isolated from various clinical samples. The authors report a case of pulmonary actinomycosis caused byA graevenitzii. A computed tomography examination revealed an excavated consolidation in the middle right lobe of a previously healthy young man who presented with a long history of moderate cough. Cultures of the bronchoalveolar lavage fluid confirmed the diagnosis of pulmonary abscess caused byA gravenitzii. At the three-month follow-up consultation and, after six weeks of high-dose amoxicillin, the pulmonary lesion had completely disappeared.

scholarly journals Disseminated Histoplasmosis in an Elderly Man Presented with Fever, Weight loss, Abdominal Pain and Haemoptysis - A Case Report with Literature Review

2011 ◽  
Vol 12 (1) ◽  
pp. 81-85
Author(s):  
Mohammad Robed Amin ◽  
Farzana Shumi ◽  
Hasibuddin Khan ◽  
Syed Ahmed Abdullah ◽  
Shafiul Alam ◽  
...  
Keyword(s):  
Elderly Patient ◽  
Weight Loss ◽  
Abdominal Pain ◽  
Case Report ◽  
Literature Review ◽  
Disseminated Histoplasmosis ◽  
History Of ◽  
Background History ◽  
Recurrent Haemoptysis ◽  
High Index Of Suspicion

An elderly patient presented with prolonged fever, gross weight loss, recurrent haemoptysis and abdominal pain. He had a background history of adrenal tuberculosis with completion of treatment without any obvious improvement. Clinically he was diagnosed as a case of adrenocotical insufficiency. Evaluation including histopathology revealed the diagnosis as disseminated histoplasmosis involving adrenal gland and lungs. The disease is a rarity without any underneath immunosuppression and hence high index of suspicion with appropriate steps for investigation is the key to achieve a diagnosis of disseminated histoplasmosis in Bangladesh. Keyword: . DOI: 10.3329/jom.v12i1.6936J Medicine 2011; 12 : 81-85

scholarly journals Rosai-Dorfman disease of the colon presented as small solitary polypoid lesion

Rare Tumors ◽  
2010 ◽  
Vol 2 (1) ◽  
pp. 5-7 ◽  
Author(s):  
Munenori Ide ◽  
Takayuki Asao ◽  
Takatomo Yoshida ◽  
Junko Hirato ◽  
Tatsuo Shimura ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Gastrointestinal Tract ◽  
Microscopic Study ◽  
Polypoid Lesion ◽  
Sinus Histiocytosis ◽  
Whole Body ◽  
Massive Lymphadenopathy ◽  
Rosai Dorfman Disease ◽  
History Of ◽  
Submucosal Mass

Rosai-Dorfman disease (RDD) was formerly known as “sinus histiocytosis with massive lymphadenopathy”, and cases involving the gastrointestinal tract are rare. We present a case of pure extranodal RDD, resected as a polypoid lesion in colonoscopic study. The patient was a 62-year old woman with a history of sigmoidectomy for unexplained peritonitis. Microscopic study of the polypoid lesion showed the submucosal mass with histological and immunological features of RDD. The whole body computed tomography revealed neither lymphadenopathy nor tumor-like mass.

Intussusception in Childhood Acute T Cell Lymphoblastic Leukemia: An Unusual Complication - Report of 2 Cases.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 4530-4530
Author(s):  
Jesika Shah ◽  
Dan Barlev ◽  
Arlene Sara Redner ◽  
Ashok Shende ◽  
Gungor Karayalcin
Keyword(s):  
Abdominal Pain ◽  
T Cell ◽  
Lymphoblastic Leukemia ◽  
Rare Complication ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Consolidation Chemotherapy ◽  
Gastrointestinal Complications ◽  
Dose Methotrexate ◽  
Descending Colon

Abstract Clinically significant gastrointestinal complications in children with acute lymphoblastic leukemia (ALL) have been reported. However, intussusception is a very rare complication. In one study of 286 children with ALL gastrointestinal complications occurred in 5.6% of patients with intussusception seen in only 0.3% of patients. We describe two cases of intussusception during chemotherapy for T-cell leukemia. Patient #1 was an 8 year old girl on chemotherapy for T-cell ALL. Around week 9 following POG 9404 protocol of consolidation chemotherapy, patient presented with severe abdominal pain and vomiting, and had marked, diffuse tenderness of the abdomen with guarding and hypo-active bowel sounds. Abdominal radiograph showed thickening of the descending colon; abdominal sonogram was normal; abdominal computed tomography (CT) scan however, revealed a soft tissue and fluid-filled mass extending from the cecum to the descending colon. These findings were consistent with a large bowel intussusception, which was successfully reduced with a barium enema. Patient #2 was a 15 year old male receiving chemotherapy for T-cell ALL following POG 9404 protocol. At week 14 of consolidation chemotherapy, patient presented with a 2 day history of nausea and colicky peri-umbilical and right lower quadrant abdominal pain. An abdominal CT scan revealed an ileocolic intussusception without bowel obstruction and mild wall thickening of the cecum. Barium enema resulted in successful reduction of the intussusception. Interestingly, both our patients were treated with high dose methotrexate 5gm/m2 during this time period and both experienced delayed excretion of methotrexate. To our knowledge, there is no known reported association between high dose methotrexate and intussusception. We speculate that the two could be related. The increased use of high dose methotrexate therapy in T-cell ALL may result in a higher incidence of intussusception in this population. Although, intussusception in ALL is a very rare complication, awareness of this entity and early recognition with radiological intervention may prevent unnecessary surgery and the associated morbidity and mortality in these patients.

Indolent T-Cell Lymphoproliferative Disorder of the Gastrointestinal Tract

2017 ◽  
Vol 112 ◽  
pp. S652-S653 ◽  
Author(s):  
Ayush Sharma ◽  
Nora N. Bennani ◽  
Andrew Feldman ◽  
Joseph A. Murray
Keyword(s):  
Gastrointestinal Tract ◽  
T Cell ◽  
Lymphoproliferative Disorder

scholarly journals Spectrum of imaging findings in trans-gastric migration of accidently ingested metallic foreign bodies

2019 ◽  
Vol 6 (3) ◽  
pp. 726
Author(s):  
Arshed Hussain Parry ◽  
Mohammad Saleem Dar ◽  
Abdul Haseeb Wani ◽  
Tariq Ahmad Gojwari ◽  
Irfan Robbani
Keyword(s):  
Computed Tomography ◽  
Gastrointestinal Tract ◽  
Foreign Body ◽  
Foreign Bodies ◽  
Vascular Complications ◽  
Greater Omentum ◽  
Imaging Findings ◽  
Accidental Ingestion ◽  
History Of ◽  
Upper Gastrointestinal

Background: An accidently ingested foreign body may get lodged within the lumen of gastrointestinal tract, pass uneventfully with feces or may migrate extraluminally into the surrounding tissues in which case it may lead to suppurative or vascular complications. The aim of the endeavor was to study the spectrum of imaging findings in patients with accidental ingestion of foreign bodies with trans-gastric migration of metallic foreign bodies.Methods: Total 33 patients with history of accidental ingestion of foreign bodies were subjected to preliminary radiograph of neck, chest and abdomen followed by upper gastrointestinal endoscopy. Failure to retrieve/ localize foreign body endoscopically from upper gastrointestinal tract with check radiograph reiterating the presence of foreign body in upper abdomen were subjected to computed tomography of abdomen.Results: A total of 33 patients comprising of 27 females and 6 males with mean age of 23.76 years with history of foreign body ingestion were studied. Ingested foreign bodies were lodged in pharynx (n=7), esophagus (n=3), stomach (n=13) or duodenum (n=3).  In 7 patients in whom endoscopy failed to locate and/or retrieve foreign body, computed tomography confirmed the presence of trans-gastrically migrated foreign body in the surrounding structures. The location of migrated foreign bodies was in lesser sac (n = 2), greater omentum (n = 3), lesser omentum (n = 1) and transmural (n = 1). Two patients had evidence of collection formation around the migrated foreign bodies.Conclusions: Sharp or pointed metallic foreign bodies may migrate trans-luminally with various implications. Though radiography is the preliminary workhorse for the confirmation of ingested foreign bodies, computed tomography owing to its volumetric data acquisition helps in exact localization of migrated foreign bodies and should precede any therapeutic intervention for retrieval of migrated foreign bodies.

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