Penehyclidine Hydrochloride Has the Function of Lung Protection for Acute Lung Injury in Rat Models:A Systemic Review and Meta-analysis
Abstract ObjectiveThis systematic review and meta-analysis aims to review the effects of penehyclidine hydrochloride (PHC) on acute lung injury in animal models. MethodsPubMed, Embase, CNKI were searched for collecting the randomized controlled trials(RCTs) on the effects of penehyclidine hydrochloride on acute lung injury in rat models from inception to July 1, 2021. We used Cochrane evaluating quality and RevMan 5.3 software performing Meta-analysis.(lung W/D ratio、PaO2/FiO2、SOD、MPO activity、IL-6 and TNF-α) ResultsOur search including 11 studies in 3 databases. Meta-analysis showed that, Compared with the acute lung injury model group, the PHC treatment group: lung W/D ratio[MD=-1.29,95%CI(-1.94,-0.64),P<0.01]、PaO2/FiO2[MD=1.73,95%CI(0.01,3.45),P<0.01]、SOD[MD=7.05,95%CI(5.58,8.52),P<0.000,01]、IL-6 [MD=-1.03,95%CI(-1.29,-0.77),P<0.0001]、IL-6 [MD=-3.35,95%CI(-5.29,-1.40),P<0.001]and TNF-α[MD=-2.17,95%CI(-3.27,-1.07),P<0.0001].Conclusionspenehyclidine hydrochloride has the function of lung protection in acute lung injury and provides a new therapy for future clinical treatment.