Long-term effects of reducing the dialysate calcium concentration on bone biomarkers in adult patients on peritoneal dialysis

2021 ◽  
Author(s):  
Maria Piraciaba ◽  
Lilian Cordeiro ◽  
Erica Adelina Guimarães ◽  
Hugo Abensur ◽  
Benedito Jorge Pereira ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Calcium Concentration ◽  
Long Term Effects ◽  
Bone Biomarkers ◽  
25 Oh Vitamin D ◽  
One Year ◽  
Serum Pth ◽  
Dialysate Calcium

Abstract Introduction: Patients on peritoneal dialysis (PD) are usually exposed to a high dialysate calcium concentration (D[Ca]), which is associated with undesirable effects. Low D[Ca] might overstimulate parathyroid hormone (PTH), as shown by previous studies carried out before the incorporation of calcimimetics in clinical practice. We hypothesized that a reduction in D[Ca] is safe and without risk for a rise in serum PTH. Methods in this prospective study, the D[Ca] was reduced from 1.75 mmol/L to 1.25 mmol/L for one year in prevalent patients on PD. Demographic, clinical, and biochemical parameters were evaluated at baseline, 3, 6, and 12 months of follow-up. Results Patients (N = 20) aged 56 ± 16 years, 50% male, 25% diabetic. There was no significant change in calcium, phosphate, alkaline phosphatase, 25(OH)-vitamin D or PTH over time. Medication adjustments included an increase in calcitriol and sevelamer. After 1 year, absolute and percentual change in PTH levels were 36 (-58, 139) pg/ml, and 20% (-28, 45) respectively. The proportion of patients with PTH > 300 pg/ml did not change during the follow-up (p = 0.173). Conclusion Low D[Ca] concentration should be considered to patients on PD as a valuable and safe option. Medication adjustments to detain PTH rising, however, are advised.

The long-term effects of homeopathic treatment of chronic headaches: one year follow-up and single case time series analysis

2001 ◽  
Vol 90 (02) ◽  
pp. 63-72 ◽  
Author(s):  
H Walach ◽  
T Lowes ◽  
D Mussbach ◽  
U Schamell ◽  
W Springer ◽  
...  
Keyword(s):  
Time Series ◽  
Single Case ◽  
Double Blind Study ◽  
Long Term Effects ◽  
Double Blind ◽  
Homeopathic Treatment ◽  
Chronic Headaches ◽  
One Year

AbstractLittle is known about long-term effects of homeopathic treatment. Following a double-blind, placebo controlled trial of classical homeopathy in chronic headaches, we conducted a 1-year observational study of 18 patients following the double-blind phase, and a complete follow-up study of all trial participants. Eighteen patients received free treatment for daily diary data (frequency, intensity, duration of headaches) over the course of 1 y. All patients enrolled in the double-blind study were sent a 6-week headache diary, a follow-up questionnaire, a personality inventory and a complaint list. Eighty-seven, of the original 98 patients enrolled returned questionnaires, 81 returned diaries. There was no additional change from the end of the trial to the one-year follow-up. The improvement seen at the end of the 12-week trial was stable after 1 y. No differential effects according to treatment after the trial could be seen. Patients with no treatment following the trial had the most improvement after 1 y. Five of 18 patients can be counted responders according to ARIMA analysis of single-case time-series. Patients with double diagnoses and longer treatment duration tended to have clearer improvements than the rest of the patients. Approximately 30% of patients in homeopathic treatment will benefit after 1 y of treatment. There is no indication of a specific, or of a delayed effect of homeopathy.

Long-term effects of empathy training in surgery residents: a one year follow-up study

2013 ◽  
Vol 1 (2) ◽  
pp. 326 ◽  
Author(s):  
Margot Phillips ◽  
Aine Lorie ◽  
John Kelley ◽  
Stacy Gray ◽  
Helen Riess
Keyword(s):  
Long Term Effects ◽  
Clinical Practices ◽  
Empathy Training ◽  
Self Reflection ◽  
Booster Sessions ◽  
Before And After ◽  
Quantitative Analyses ◽  
One Year

Objectives: This study is a 1-year follow-up investigation of the retention of the knowledge, attitudes and skills acquired after empathy training.Methods: Eight otolaryngology residents completed 5 assessment measures before and after empathy training and at 1-year. They attended a 90-minute focus group assessing clinical usefulness of the training, attitudes and factors that affect empathy.Results: Qualitative analysis revealed a positive response to the training and application of skills to clinical practices. Quantitative analyses suggest improvement in empathy after training was maintained at 1-year follow-up (p = 0.05). Knowledge of the neurobiology and physiology of empathy remained significantly greater than before the training (p = 0.007). Conclusions: Qualitative data indicate that the training program was well-received and helpful and follow-up focus groups provided physicians with opportunities for self-reflection and support from peers. Quantitative analysis demonstrated that improvement in self-reported empathy and objective knowledge of the neurobiology of emotions persist at 1-year follow-up. Accordingly, we recommend that empathy training and follow-up booster sessions become a standard component of residency training.

Long-term effects of orthotic insoles in rheumatoid arthritis—A one-year year longitudinal follow-up

2006 ◽  
Vol 24 ◽  
pp. S178-S179
Author(s):  
Arne Nagel ◽  
Henrik Schmiegel Andreas Lars ◽  
Dieter Rosenbaum
Keyword(s):  
Rheumatoid Arthritis ◽  
Long Term Effects ◽  
One Year ◽  
Orthotic Insoles

Long-term effects of orthotic insoles in rheumatoid arthritis – A one-year longitudinal follow-up of barefoot loading

2008 ◽  
Vol 23 (5) ◽  
pp. 684-685
Author(s):  
Arne Nagel ◽  
Lars Hendrik Meyer ◽  
Andreas Schmiegel ◽  
Dietmar Walter ◽  
Dieter Rosenbaum
Keyword(s):  
Rheumatoid Arthritis ◽  
Long Term Effects ◽  
One Year ◽  
Orthotic Insoles

The Curled Catheter: Dependable Device for Percutaneous Peritoneal Access

1990 ◽  
Vol 10 (3) ◽  
pp. 231-235 ◽  
Author(s):  
Richard Swartz ◽  
Joseph Messana ◽  
Leslie Rocher ◽  
Janice Reynolds ◽  
Barbara Starmann ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Infectious Complications ◽  
Peritoneal Dialysis Catheter ◽  
Catheter Migration ◽  
Table Analysis ◽  
Combined Infection ◽  
One Year ◽  
Comparable Size

The curled peritoneal dialysis catheter is theoretically less prone to catheter migration and drainage failure. It also allows percutaneous placement, rather than surgical placement exclusively, whenever desired or necessary. Review of 213 curled-catheter placements, 134 (63%) percutaneous and 79 (37%) surgical, over the last 4 years, shows that the probability of continuing catheter function by life-table analysis was 88% at one year, 71% at 2 years, and 61% at three years, with no difference comparing percutaneous to surgical placement. Among the 213 total cases, nearly 50% of all catheters were still functioning at last follow up, and 38 catheters (17.8%) have been lost in total, attributed to infectious complications in 24 cases (tunnel-exit infection alone in 5, peritonitis alone in 11, combined infection in 8), refractory drain failure in 9 cases (early drain failure in 4, late drain failure in 5), recurrent late subcutaneous dialysate leaking in 3 cases, and peri-catheter hernia in 2 cases. Among other complications, the incidence of early drain failure (7.0%), and late drain failure (4.2%), compare favorably to reports describing other devices or other placement methods having comparable size of reported experience. Analyzing our own percutaneous and surgical placements separately, there were no differences in the respective frequencies of early drain failure, late drain failure, late subcutaneous dialysate leaking, outer cuff extrusion, required hernia repair, peritonitis or tunnel-exit infection. Only early external dialysate leaking was more frequent using percutaneous placement methods (21.6% vs. 10.1%; p < 0.05), although no catheters were lost due to early external leaking. In conclusion, the present experience suggests that the curled catheter is both amenable to safe and convenient percutaneous placement methods in the majority of cases, as well as dependable for long-term peritoneal dialysis in a large university program.

scholarly journals Calcium kinetics and the long-term effects of lowering dialysate calcium concentration

1993 ◽  
Vol 43 (3) ◽  
pp. 630-640 ◽  
Author(s):  
Àngel Argilés ◽  
Peter G. Kerr ◽  
Bernard Canaud ◽  
Jean Louis Flavier ◽  
Charles Mion
Keyword(s):  
Calcium Concentration ◽  
Long Term Effects ◽  
Calcium Kinetics ◽  
Dialysate Calcium

scholarly journals The Long-Term Effects of Lifestyle Change on Blood Pressure: One-Year Follow-Up of the ENCORE Study

2013 ◽  
Vol 27 (5) ◽  
pp. 734-741 ◽  
Author(s):  
A. L. Hinderliter ◽  
A. Sherwood ◽  
L. W. Craighead ◽  
P.-H. Lin ◽  
L. Watkins ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Lifestyle Change ◽  
Long Term Effects ◽  
One Year

Long-Term Effects of Peer Group Confrontation Therapy Used with Polydrug Abusers

1977 ◽  
Vol 7 (2) ◽  
pp. 135-149 ◽  
Author(s):  
Norman L. Stephenson ◽  
Patrick A. Boudewyns ◽  
Rudolph A. Lessing
Keyword(s):  
Peer Group ◽  
Community Setting ◽  
Psychological Tests ◽  
Therapeutic Outcome ◽  
Long Term Effects ◽  
Process Data ◽  
One Year ◽  
Male Veteran

Outcome and process data are reported on 98 male veteran polydrug abusers (non-heroin addicts) treated with peer group confrontation therapy in an inpatient therapeutic community setting. One year follow-up data are reported on 79% of the sample. A number of demographic and other descriptive variables were found to be predictive of therapeutic outcome; psychological tests did not predict outcome.

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