The Value of The Accessory Pathway Potential in Guiding The Electrode Selection for Ablation Within Coronary Sinus

Abstract Background: The ablation of the coronary sinus (CS) is becoming more and more important in accessory pathway-related supraventricular tachycardia ablation. In comparison with temperature-controlled catheters (TCC), irrigated-tip catheter (ITC) are more expensive and cause more damage in accessory pathway-related supraventricular tachycardia ablation. We intended to develop a new method for the reasonable selection of electrode for coronary sinus(CS) ablation via assessing the relationship between the accessory pathway (AP) potential and time of successful ablation. Methods：Among the patients who had detected the bypass potential during radiofrequency ablation between 1/1/2015 and 12/31/2019. TCC was performed in 330 patients receiving endocardial ablation. 30 patients underwent radiofrequency catheter ablation (RFCA) in CS. The relationship between AP potential and time of successful ablation was analyzed. Results：330 cases of TCC ablation within the endocardium revealed that the amplitude of AP potential was significantly and negatively correlated with the time of successful ablation (r = -0.79, p < 0.001). In CS ablation, the median baseline amplitude of the AP potentials in patients with successful TCC ablation was higher than that in patients with ITC following TCC ablation failure (p = 0.02). The optimal cutoff value of the amplitude of the AP potential to guide the selection of a catheter for ablation was 1.07 mV, and the sensitivity and specificity were 80% and 90%, respectively. Conclusion：The AP potential is helpful for the electrode selection in CS ablation.

Download Full-text

The value of the accessory pathway potential in ablation within coronary sinus

10.21203/rs.3.rs-793030/v1 ◽

2021 ◽

Author(s):

Xiaolin Sun ◽

Pei Xu ◽

Tian Xia ◽

Zhengyu Bao

Keyword(s):

Catheter Ablation ◽

Coronary Sinus ◽

Radiofrequency Catheter Ablation ◽

Accessory Pathway ◽

Optimal Cutoff ◽

Cutoff Value ◽

Successful Ablation ◽

The Relationship ◽

Electrode Selection ◽

Selection Of

Abstract Background In accessory pathway-related supraventricular tachycardia ablation, coronary sinus (CS) ablation has received more and more attention, but there are no accurate criteria for catheter selection. Objectives We intended to develop a new method for the reasonable selection of electrode for coronary sinus ablation via assessing the relationship between the accessory pathway (AP) potential and time of successful ablation. Methods Among the patients who had detected the bypass potential during radiofre-quency ablation between 1/1/2015 and 12/31/2019, 30 patients underwent radiofrequency catheter ablation (RFCA) in CS. The relationship between AP potential and time of successful ablation was analyzed. Results In CS ablation, the median baseline amplitude of the AP potentials in patients with successful Temperature control catheter (TCC) ablation was higher than that in patients with Irrigated-tip catheter (ITC) following TCC ablation failure (p = 0.02). The optimal cutoff value of the amplitude of the AP potential to guide the selection of a catheter for ablation was 1.07 mV, and the sensitivity and specificity were 80% and 90%, respectively. Conclusions The AP potential is helpful for the electrode selection in CS ablation.

Download Full-text

Successful ablation of a left anterior accessory pathway from the left coronary sinus of Valsalva near the aortic–mitral continuity

Journal of International Medical Research ◽

10.1177/0300060521990249 ◽

2021 ◽

Vol 49 (3) ◽

pp. 030006052199024

Author(s):

Fan Wang ◽

Xuelian Song ◽

Yi Dang ◽

Shangzhi Shu ◽

Shuyan Li

Keyword(s):

Catheter Ablation ◽

Coronary Sinus ◽

Radiofrequency Catheter Ablation ◽

Accessory Pathway ◽

Sinus Of Valsalva ◽

Long Term Outcomes ◽

Accessory Pathways ◽

Successful Ablation

Catheter ablation of accessory pathways can be challenging depending on the location of these pathways, and accessory pathways are rare through the aortic cusps. We report a patient who underwent radiofrequency catheter ablation for manifestation of a left anterior accessory pathway from the left coronary sinus of Valsalva near the aortic–mitral continuity. Anterior accessory pathways can be safely and effectively ablated from the aortic cusps with favorable long-term outcomes.

Download Full-text

Relationship between Ceftolozane-Tazobactam Exposure and Selection for Pseudomonas aeruginosa Resistance in a Hollow-Fiber Infection Model

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.02310-13 ◽

2014 ◽

Vol 58 (10) ◽

pp. 6024-6031 ◽

Cited By ~ 27

Author(s):

Brian D. VanScoy ◽

Rodrigo E. Mendes ◽

Mariana Castanheira ◽

Jennifer McCauley ◽

Sujata M. Bhavnani ◽

...

Keyword(s):

Drug Resistance ◽

Infection Model ◽

Drug Resistant ◽

Wild Type ◽

Resistance Selection ◽

Atcc Strain ◽

Dosing Regimens ◽

Selection For ◽

The Relationship ◽

Selection Of

ABSTRACTIt is important to understand the relationship between antibiotic exposure and the selection of drug resistance in the context of therapy exposure. We sought to identify the ceftolozane-tazobactam exposure necessary to prevent the amplification of drug-resistant bacterial subpopulations in a hollow-fiber infection model. TwoPseudomonas aeruginosachallenge isolates were selected for study, a wild-type ATCC strain (ceftolozane-tazobactam MIC, 0.5 mg/liter) and a clinical isolate (ceftolozane-tazobactam MIC, 4 mg/liter). The experiment duration was 10 days, and the ceftolozane-tazobactam dose ratio (2:1) and dosing interval (every 8 h) were selected to approximate those expected to be used clinically. The studied ceftolozane-tazobactam dosing regimens ranged from 62.5/31.25 to 2,000/1,000 mg per dose in step fold dilutions. Negative-control arms included no treatment and tazobactam at 500 mg every 8 h. Positive-control arms included ceftolozane at 1 g every 8 h and piperacillin-tazobactam dosed at 4.5 g every 6 h. For the wild-type ATCC strain, resistance was not selected by any ceftolozane-tazobactam regimen evaluated. For the clinical isolate, an inverted-U-shaped function best described the relationship between the amplification of a drug-resistant subpopulation and drug exposure. The least (62.5/31.25 mg) and most (2,000/1,000 mg) intensive ceftolozane-tazobactam dosing regimens did not select for drug resistance. Drug resistance selection was observed with intermediately intensive dosing regimens (125/62.5 through 1,000/500 mg). For the intermediately intensive ceftolozane-tazobactam dosing regimens, the duration until the selection for drug resistance increased with dose regimen intensity. These data support the selection of ceftolozane-tazobactam dosing regimens that minimize the potential for on-therapy drug resistance selection.

Download Full-text

Selection practices in dairy herds. 1. First lactation performance and survival to the second lactation

Animal Science ◽

10.1017/s0003356100038149 ◽

1966 ◽

Vol 8 (3) ◽

pp. 467-480 ◽

Cited By ~ 10

Author(s):

C. J. M. Hinks

Keyword(s):

Milk Yield ◽

Selection Procedure ◽

Dairy Herds ◽

Productive Capacity ◽

Lactation Performance ◽

Selection For ◽

Calving Season ◽

Main Determinants ◽

The Relationship ◽

Selection Of

1. The relationship between first lactation performance and the ability of individual animals to survive to the second lactation has been examined in Friesian and Ayrshire populations in an attempt to isolate the main determinants of survival, and to rationalise an apparently complicated selection procedure.2. Low milk yield was the most important single cause of culling in the first lactation, though the two breeds differed considerably in the relative importance of milk yield in the selection programme. Natural wastage, caused by factors beyond the control of the farmer, accounted for the disposal of 5·7% of the population during the first lactation. Selection for butterfat was marginal in both populations, and could only be detected at extreme butterfat percentages, where high butterfat tended to compensate for a poor milk yield, and low butterfat to confirm a decision to cull an average yielding animal. Survival was not significantly affected either by the size of the herd or by the age at calving.3. The proportion culled, and the intensity and effectiveness of selection for milk yield, were inversely related to the level of herd performance, and were greater in summer calving animals than in winter calvers.4. The analysis indicated that selection for milk yield in different environments could be adequately described in terms of the Normal Curve. Yield-survival curves were computed and compared for groups of animals in different herd and calving season environments. When milk yield was expressed in terms of the deviation from the herd-year average, it was found that summer calvers, and animals in low yielding herds, had to demonstrate a productive capacity of far greater individual merit, if their chances of survival were to match those of their winter calving herdmates, and those of their contemporaries in higher yielding herds. When milk yield was expressed in absolute terms the survival of individual animals of similar yield was comparable in all herd and season environments. It was concluded that all the herds included in the analysis had been subject to the same absolute standards of milk yield in the selection of first calvers.

Download Full-text

Continuous Ambulatory Peritoneal Dialysis: An Option in the Developing World?

Peritoneal Dialysis International ◽

10.1177/089686089401400109 ◽

1994 ◽

Vol 14 (1) ◽

pp. 48-51 ◽

Cited By ~ 26

Author(s):

Roy Lent ◽

Jonathan E. Myers ◽

Deidre Donald ◽

Brian L. Rayner

Keyword(s):

Peritoneal Dialysis ◽

Continuous Ambulatory Peritoneal Dialysis ◽

Tertiary Care ◽

Therapeutic Success ◽

Explanatory Variables ◽

Large Tertiary Care ◽

Selection For ◽

The Relationship ◽

Selection Of Patients ◽

Selection Of

Objective To evaluate specified biomedical, socio-economic, and psychosocial criteria as predictors of therapeutic success to optimize patient selection for continuous ambulatory peritoneal dialysis (CAPD) in a developing country. Design A restrospective cohort study investigating the relationship between episodes of peritonitis and exitsite infection, and predetermined biomedical, socioeconomic, and psychosocial data. Setting A CAPD unit in a large tertiary care teaching hospital. Patients AI1132 patients entering the CAPD program between 1987 and 1991. Results Overall mean survival time on CAPD was 17.3 months. Peritonitis rates were high, especially among blacks. Multivariate analysis demonstrated that increased peritonitis rates were associated with age, black race, diabetes, and strongly so with several psychosocial factors. Because being black was strongly linked to poor socioeconomic conditions, repeat analysis excluding blacks showed the same associations with the above variables, but, additionally, several socioeconomic factors were associated with high peritonitis rates. No significant explanatory variables were shown for exit-site infections. Conclusions The association of biomedical, socio-economic, and psychosocial variables with high peritonitis rates has important implications for the selection of patients for CAPD in this setting.

Download Full-text

A posteroseptal accessory pathway located in a coronary sinus aneurysm: diagnosis and radiofrequency catheter ablation

Heart ◽

10.1136/hrt.68.10.414 ◽

1992 ◽

Vol 68 (10) ◽

pp. 414-416 ◽

Cited By ~ 13

Author(s):

A K Pedersen ◽

R Benetis ◽

P E B Thomsen

Keyword(s):

Catheter Ablation ◽

Coronary Sinus ◽

Radiofrequency Catheter Ablation ◽

Accessory Pathway ◽

Posteroseptal Accessory Pathway

Download Full-text

Radiofrequency Catheter Ablation of Posterior Paraseptal Accessory Pathway with Atresia of the Coronary Sinus Ostium

Pacing and Clinical Electrophysiology ◽

10.1111/j.1540-8159.2011.03211.x ◽

2011 ◽

Vol 35 (4) ◽

pp. e80-e83 ◽

Cited By ~ 3

Author(s):

SUSUMU YOSHIDA ◽

HIROSHI YOKOE ◽

KOUSUKE MURAKAWA ◽

MASAHIKO TAKAGI ◽

FUMIO YUASA ◽

...

Keyword(s):

Catheter Ablation ◽

Coronary Sinus ◽

Radiofrequency Catheter Ablation ◽

Accessory Pathway ◽

Coronary Sinus Ostium ◽

Sinus Ostium

Download Full-text

Radiofrequency catheter ablation of atrioventricular accessory pathways in Wolff-Parkinson-White syndrome with drug-refractory and symptomatic supraventricular tachycardia. Its high effectiveness irrespective of accessory pathway location and properties.

Japanese Circulation Journal ◽

10.1253/jcj.58.767 ◽

1994 ◽

Vol 58 (10) ◽

pp. 767-777 ◽

Cited By ~ 5

Author(s):

YOSHITO IESAKA ◽

ATSUSHI TAKAHASHI ◽

CHUN YEONG-HWA ◽

MASAYUKI IGAWA ◽

TAKESHI TOKUNAGA ◽

...

Keyword(s):

Catheter Ablation ◽

Supraventricular Tachycardia ◽

Radiofrequency Catheter Ablation ◽

Accessory Pathway ◽

High Effectiveness ◽

White Syndrome ◽

Accessory Pathways ◽

Wolff Parkinson White Syndrome

Download Full-text

Systematic selection of competing metabolomics methods in a metabolite-sensory relationship study

Metabolomics ◽

10.1007/s11306-021-01821-3 ◽

2021 ◽

Vol 17 (9) ◽

Author(s):

Naser Davarzani ◽

Carmen Diez-Simon ◽

Justus L. Großmann ◽

Doris M. Jacobs ◽

Rudi van Doorn ◽

...

Keyword(s):

Sensory Profile ◽

Small Set ◽

Selection For ◽

Systematic Selection ◽

The Relationship ◽

Tomato Soup ◽

Final Selection ◽

Selection Of

Abstract Introduction The relationship between the chemical composition of food products and their sensory profile is a complex association confronting many challenges. However, new untargeted methodologies are helping correlate metabolites with sensory characteristics in a simpler manner. Nevertheless, in the pilot phase of a project, where only a small set of products are used to explore the relationships, choices have to be made about the most appropriate untargeted metabolomics methodology. Objective To provide a framework for selecting a metabolite-sensory methodology based on: the quality of measurements, the relevance of the detected metabolites in terms of distinguishing between products or in terms of whether they can be related to the sensory attributes of the products. Methods In this paper we introduce a systematic approach to explore all these different aspects driving the choice for the most appropriate metabolomics method. Results As an example we have used a tomato soup project where the choice between two sampling methods (SPME and SBSE) had to be made. The results are not always consistently pointing to the same method as being the best. SPME was able to detect metabolites with a better precision, SBSE seemed to be able to provide a better distinction between the soups. Conclusion The three levels of comparison provide information on how the methods could perform in a follow up study and will help the researcher to make a final selection for the most appropriate method based on their strengths and weaknesses.

Download Full-text