scholarly journals Tear Film Stability After Primary Pterygium Excision Combined with Limbal Stem Cell Transplantation is Superior to Amniotic Membrane Transplantation: A Meta-Analysis

2021 ◽  
Author(s):  
Chuanjie Yin ◽  
Yinlei Bao ◽  
Suifang Kang ◽  
Qichen Zhang ◽  
Guoling Chen
Keyword(s):  
Stem Cell ◽  
Meta Analysis ◽  
Tear Film ◽  
Amniotic Membrane Transplantation ◽  
Film Stability ◽  
Tear Film Stability ◽  
Limbal Stem Cell Transplantation ◽  
Pterygium Excision ◽  
Limbal Stem Cell ◽  
Primary Pterygium

Abstract Purpose To evaluate the tear film stability after primary pterygium excision combined with Limbal stem cell transplantation (LSCT) or amniotic membrane transplantation (AMT). Methods We searched the PubMed, EMBASE, Web of Science, Cochrane Library, CNKI, Wan Fang and VIP databases for all studies on tear film stability after primary pterygium excision combined with LSCT or AMT. The mean difference (MD) and 95% confidence interval (CI) were calculated for outcomes using the fixed effect or random effect model.Results Seven studies with a total of 531 eyes were enrolled in our meta-analysis, which revealed that comparison between the LSCT group and the AMT group: Ocular Surface Disease Index (OSDI) 3 months postoperatively (MD=-5.16, 95%CI:-6.48,-3.85, P＜0.05), Tear break-up time (BUT) 1 or 3 months postoperatively (1 month: MD=0.30, 95%CI:-0.66,1.26, P=0.54; 3 months: MD=1.30, 95%CI:-0.13,2.72, P=0.07), Schirmer I test 1 or 3 months postoperatively (1 month: MD=0.05, 95%CI:-0.41,0.51, P=0.82; 3 months: MD=1.41, 95%CI:0.81,2.02, P＜0.05), Corneal fluorescein staining (CFS) score 1 month postoperatively (MD=-0.49, 95%CI:-1.29,0.31, P=0.23).Conclusion Primary pterygium excision combined with LSCT is associated with better tear film stability changes than AMT.

scholarly journals Recent Advances in the Effects of Various Surgical Methods on Tear Film after Pterygium Surgery

2021 ◽  
Author(s):  
Juan Wang
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Dry Eye ◽  
Tear Film ◽  
Amniotic Membrane Transplantation ◽  
Surgical Methods ◽  
Close Relationship ◽  
Limbal Stem Cell Transplantation ◽  
Limbal Stem Cell

Pterygium is a common ocular disorder with a high prevalence. Surgical resection is the main method of treating pterygium. Recurrence rate of traditional surgical methods such as simple excision of pterygium is high. In recent years, amniotic membrane transplantation, autologous limbal stem cell transplantation, application of mitomycin (MMC) and some other methods become commonly used. Autologous limbal stem cell transplantation is being most widely used. Pterygium has a close relationship with dry eye, and dry eye is one of the important reasons for its recurrence. Different surgical methods have different effects on postoperative tear film. This review will summarize the recent points.

scholarly journals Comparison between limbal stem cell versus dry amniotic membrane transplantation in treatment of primary pterygium

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A M Ghanem ◽  
F M Zaher ◽  
A G Salman ◽  
R M Nabil
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Amniotic Membrane ◽  
Amniotic Membrane Transplantation ◽  
Significant Difference ◽  
Limbal Stem Cell Transplantation ◽  
Pterygium Excision ◽  
Limbal Stem Cell

Abstract Background Pterygium is a degenerative disorder of the conjunctiva which leads to encroachment of bulbar conjunctiva onto the cornea. This invasion causes irritation of ocular surface, irregular astigmatism and loss of visual acuity.surgical treatment of pterygium is directrd towards excision, prevention of recurrence and restoration of ocular surface integrity. A myriad of techniques have been described for achieving these goals. Tha main complication of these procedures is the recurrence rate, which has been estimated as high as 30%_70%. Purpose to compare the efficiency of limbal stem cell transplantation versus dry amniotic membrane transplantation in treatment of pterygium. Patients and Methods The study carried out at ophthalmology department, Ain shams university and included 20 eyes which were classified into two groups; first group included 10 eyes of patients underwent pterygium excision with amniotic membrane transplantation. Second group included 10 eyes of patients underwent pterygium excision with limbal stem cell transplantation. Results the mean follow up duration was 1-3 months in both groups. On comparing recurrence rate between the studied groups which occurred only in the first group in two eyes 20%, there is no statistically significant difference found between the studied groups as regard recurrence. But it was statistically significant better with limbal conjunctival autografting. Graft rejection was not detected in the two groups during follow up period. There was no statistically significant difference found between the studied groups as regard clinical stability and graft rejection. Conclusion Limbal stem cell transplantation proved to be better than amniotic membrane transplantation in treatment of pterygium. As it is more effective in prevention of pterygium reccurence as well as it is of lower cost and better availability than amniotic membrane.

A PROSPECTIVE ANALYSIS OF VISUAL ACUITY AND ASTIGMATIC CHANGES AFTER PTERYGIUM EXCISION WITH LIMBAL STEM CELL GRAFTING

2021 ◽  
pp. 21-23
Author(s):  
Kumari Preeti ◽  
Nitu Kumari ◽  
[Prof.] Alka Jha ◽  
Debarshi Jana
Keyword(s):  
Visual Acuity ◽  
Stem Cell ◽  
Corneal Astigmatism ◽  
Surgical Removal ◽  
Prospective Analysis ◽  
Cell Grafting ◽  
Induced Astigmatism ◽  
Pterygium Excision ◽  
Limbal Stem Cell ◽  
Primary Pterygium

Objectives: The aim of this study was to assess if there is any signicant reduction in astigmatism and thus improvement in visual acuity after pterygium excision with limbal stem cell grafting. Methods: In this prospective study, patients with primary pterygium were included. Preoperative and postoperative corneal astigmatism, refractive astigmatism and visual acuity were analyzed. All patients underwent pterygium excision with limbal stem cell grafting. Results: Mean improvement in visual acuity of 0.09 log MAR units was observed (p <0.0001, statistically signicant).Mean corneal astigmatism for grade I, II and III was found to be 1.03 ± 0.68D, 1.69 ± 0.80D and 2.90 ± 1.06D respectively. Mean corneal astigmatism decreased by 1.29 D (p <0.0001, statistically signicant).A decrease of 0.77D in cylindrical power required was found after surgery (p <0.0001, statistically signicant). Conclusions: there is a signicant reduction in pterygium induced astigmatism and improvement in visual acuity on surgical removal of the pterygium.

The ocular surface in children: A review of current knowledge and meta-analysis of tear film stability and tear secretion in children

2019 ◽  
Vol 17 (1) ◽  
pp. 28-39 ◽  
Author(s):  
Ngozi Charity Chidi-Egboka ◽  
Nancy E. Briggs ◽  
Isabelle Jalbert ◽  
Blanka Golebiowski
Keyword(s):  
Ocular Surface ◽  
Current Knowledge ◽  
Meta Analysis ◽  
Tear Film ◽  
Film Stability ◽  
Tear Secretion ◽  
Tear Film Stability

scholarly journals The Ocular Surface Chemical Burns

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Medi Eslani ◽  
Alireza Baradaran-Rafii ◽  
Asadolah Movahedan ◽  
Ali R. Djalilian
Keyword(s):  
Stem Cell ◽  
Ocular Surface ◽  
Clinical Course ◽  
Amniotic Membrane Transplantation ◽  
Surface Chemical ◽  
Chemical Burns ◽  
Surface Anatomy ◽  
Limbal Stem Cell Transplantation ◽  
Limbal Stem Cell ◽  
And Function

Ocular chemical burns are common and serious ocular emergencies that require immediate and intensive evaluation and care. The victims of such incidents are usually young, and therefore loss of vision and disfigurement could dramatically affect their lives. The clinical course can be divided into immediate, acute, early, and late reparative phases. The degree of limbal, corneal, and conjunctival involvement at the time of injury is critically associated with prognosis. The treatment starts with simple but vision saving steps and is continued with complicated surgical procedures later in the course of the disease. The goal of treatment is to restore the normal ocular surface anatomy and function. Limbal stem cell transplantation, amniotic membrane transplantation, and ultimately keratoprosthesis may be indicated depending on the patients’ needs.

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