scholarly journals Evidence of Plasmodium falciparum infection after 12 years from the exposure: cryptic malaria or recrudescence?

Author(s):  
Ildebrando Patamia ◽  
Elisa Cappello ◽  
Maddalena Calvo ◽  
Giuseppe Migliorisi ◽  
Antonina Franco

Abstract BackgroundMalaria infections affect a high percentage of the world's population, especially in tropical and subtropical regions. Specifically, Plasmodium falciparum is the most relevant species involved in the etiopathogenesis of this infection. The duration of P. falciparum infections is often undefined, as some reported episodes of suspected recrudescence occur several years after initial exposure.Case presentationWe present a case report of malaria infection with low parasitaemia in a man whose last stay in an endemic region or contacts with the local population was twelve years ago. The patient recovered fully with adequate antimalarial treatment, but some aspects of his clinical history were not clearly defined.ConclusionsWe discuss here the possibility that this is either a P. falciparum recrudescence or an episode of cryptic malaria, as we cannot carefully verify some details of our patient's life and history.

2014 ◽  
Vol 1 (2) ◽  
Author(s):  
Krishanthi Subramaniam ◽  
Rebeca M. Plank ◽  
Nina Lin ◽  
Adam Goldman-Yassen ◽  
Emil Ivan ◽  
...  

Abstract Background.  Plasmodium falciparum infection has been reported to increase human immunodeficiency virus (HIV) viral load (VL), which can facilitate HIV transmission. We prospectively studied the impact of mild P falciparum coinfection on HIV VL in Rwanda. Methods.  We measured plasma HIV VL at presentation with malaria infection and weekly for 4 weeks after artemether-lumefantrine treatment in Rwandan adults infected with HIV with P falciparum malaria. Regression analyses were used to examine associations between malaria infection and HIV VL changes. Samples with detectable virus underwent genotypic drug-resistance testing. Results.  We enrolled 28 HIV-malaria coinfected patients and observed 27 of them for 5 weeks. Three patients (11%) were newly diagnosed with HIV. Acute P falciparum infection had no significant effect on HIV VL slope over 28 days of follow-up. Ten patients with VL <40 copies/mL at enrollment maintained viral suppression throughout. Seventeen patients had a detectable VL at enrollment including 9 (53%) who reported 100% adherence to ARVs; 3 of these had detectable genotypic drug resistance. Conclusions.  Unlike studies from highly malaria-endemic areas, we did not identify an effect of P falciparum infection on HIV VL; therefore, malaria is not likely to increase HIV-transmission risk in our setting. However, routine HIV testing should be offered to adults presenting with acute malaria in Rwanda. Most importantly, we identified a large percentage of patients with detectable HIV VL despite antiretroviral (ARV) therapy. Some of these patients had HIV genotypic drug resistance. Larger studies are needed to define the prevalence and factors associated with detectable HIV VL in patients prescribed ARVs in Rwanda.


2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Mateusz M. Plucinski ◽  
Peter D. McElroy ◽  
Pedro Rafael Dimbu ◽  
Filomeno Fortes ◽  
Doug Nace ◽  
...  

2019 ◽  
Vol 59 (1) ◽  
pp. 71
Author(s):  
Matheus Dias Girão Rocha ◽  
Evelyne Santana Girão ◽  
Janete Romão Santos ◽  
Roberto Justa Pires Neto

Severe imported malaria is a clinically significant problem in non-endemic areas. We report two cases of travelers with Plasmodium falciparum infection who traveled from Africa and came home to a Brazilian non-endemic region. The epidemiology and diagnostic aspects of severe imported malaria for travel medicine clinicians in non-endemic regions are reviewed.


1981 ◽  
Vol 46 (02) ◽  
pp. 547-549 ◽  
Author(s):  
E M Essien ◽  
M I Ebhota

SummaryDuring acute malaria infection, platelets in human platelet-rich plasma are hypersensitive to the addition of ADP between 1.0 uM and 5.0 uM, or adrenaline 0.11 uM as aggregating agents. The mean maximum aggregation amplitude (as % of light transmission) obtained from 8 subjects in response to added ADP (1.0 uM), 39.8 ± 27 (1SD), was significantly greater than the value in 6 controls (5.2±6.7 (1SD); t = 3, 51 P <0.005). A similar pattern of response was obtained with higher ADP concentrations (2.4,4.5 or 5.0 uM) in 22 patients and 20 control subjects (89.9±14.9% vs 77.8±16.5% (1SD) t = 2.45, P <0.02). Addition of 4.5 uM ADP to patient PRP usually evoked only a single aggregation wave (fused primary and secondary waves) while the typical primary and secondary wave pattern was usually obtained from controls.Mean plasma B-thromboglobulin (BTG) concentration in 7 patients (208.3 ± 15.6 ng/ml) was significantly higher than the value in 6 control subjects (59.2±15.7 ng/ml; t = 13.44, P <0.002).


2020 ◽  
Vol 1 (9) ◽  
pp. 100157
Author(s):  
Jo-Anne Chan ◽  
Jessica R. Loughland ◽  
Fabian de Labastida Rivera ◽  
Arya SheelaNair ◽  
Dean W. Andrew ◽  
...  

2006 ◽  
Vol 36 (3) ◽  
pp. 353-360 ◽  
Author(s):  
John B. Sacci ◽  
Uzma Alam ◽  
Donna Douglas ◽  
Jamie Lewis ◽  
D Lorne J. Tyrrell ◽  
...  

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