Tissue Microarray Assessment of Novel Prostate Cancer Biomarkers AMACR and EZH2 and Immunologic Response to Them in African-American and Caucasian Men

2007 ◽  
Author(s):  
Rohit Mehra
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Tissue Microarray ◽  
Cancer Biomarkers ◽  
Immunologic Response ◽  
Caucasian Men

scholarly journals Comparison of germline mutations in African American and Caucasian men with metastatic prostate cancer

The Prostate ◽  
2021 ◽  
Author(s):  
Elisa M. Ledet ◽  
Earle F. Burgess ◽  
Alexandra O. Sokolova ◽  
Ellen B. Jaeger ◽  
Whitley Hatton ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Metastatic Prostate Cancer ◽  
Germline Mutations ◽  
Caucasian Men

Abstract C10: Immunoseroproteomic profiling of autoantibodies to tumor-associated autoantigens in African American and Caucasian men with prostate cancer

2014 ◽  
Author(s):  
Tino W. Sanchez ◽  
Saied Mirshahidi ◽  
Nathan R. Wall ◽  
Colwick Wilson ◽  
Susanne Montgomery ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Caucasian Men

scholarly journals Genome-wide differentially methylated genes in prostate cancer tissues from African-American and Caucasian men

Epigenetics ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. 319-328 ◽  
Author(s):  
JM Devaney ◽  
S Wang ◽  
P Furbert-Harris ◽  
V Apprey ◽  
M Ittmann ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Genome Wide ◽  
Differentially Methylated Genes ◽  
Caucasian Men ◽  
Cancer Tissues

scholarly journals African American men with low-grade prostate cancer have increased disease recurrence after prostatectomy compared with Caucasian men

2015 ◽  
Vol 33 (2) ◽  
pp. 70.e15-70.e22 ◽  
Author(s):  
Kosj Yamoah ◽  
Curtiland Deville ◽  
Neha Vapiwala ◽  
Elaine Spangler ◽  
Charnita M. Zeigler-Johnson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
African American Men ◽  
Disease Recurrence ◽  
Low Grade ◽  
Caucasian Men

Obesity and prostate cancer screening among african-american and caucasian men

The Prostate ◽  
2006 ◽  
Vol 66 (13) ◽  
pp. 1371-1380 ◽  
Author(s):  
Jay H. Fowke ◽  
Lisa B. Signorello ◽  
Willie Underwood ◽  
Flora A.M. Ukoli ◽  
William J. Blot
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Cancer Screening ◽  
Prostate Cancer Screening ◽  
Caucasian Men

Risk of more advanced cancer at surgery in African American men eligible for active surveillance.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e15214-e15214
Author(s):  
Amirali H Salmasi ◽  
Misop Han ◽  
Isaac Yi Kim
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Advanced Cancer ◽  
Active Surveillance ◽  
African American Men ◽  
Low Grade ◽  
Inclusion Criteria ◽  
Medical Institutions ◽  
Caucasian Men ◽  
Preoperative Predictors

e15214 Background: African-American (AA) men have a higher risk for developing prostate cancer (PCa) and dying of PCa compared to Caucasian men. Active surveillance (AS) is an acceptable management for males with low volume and low grade PCa. In Caucasian men who were eligible for AS, the risk of non-organ-confined disease [NOC] at radical prostatectomy (RP) ranges between 7.8 and 10.9% (Kang et al 2011, Mufarrij et al 2010). It is unclear whether AA men with favorable risk PCa can undergo AS safely. We evaluated changes in staging and grading of PCa in a cohort of AA males that met the criteria for AS but underwent RP. Methods: Between 1997 and 2011, 1536 AA men underwent RP at either Johns Hopkins Medical Institutions or Cancer Institute of New Jersey. Pathological characteristics of patients who fulfilled the inclusion criteria under the National Cancer Institute (NCI) AS criteria were examined. NOC (ECE/SV+/LN+) and upgrading (Gleason <7 in biopsy to Gleason >6 in RP) was evaluated. We tried to identify preoperative predictors of more advanced cancer (NOC and/or upgrading). Results: We identified 212 men who underwent RP, eligible for AS based on NCI criteria. Among 212 men, 92 (37.7%) men showed NOC and/or upgrading, defined SV involvement in 5 (2.4%), ECE in 53 (25%), and increased Gleason (<7 to >6) in 69 (32%) men. Pre-operative PSA level (OR 1.2, p < 0.05) and age (OR 1.06, p < 0.01) were significantly associated with more advanced cancer. No significant association was found between BMI, tissue percentage, or positive cores with more advanced cancer. Conclusions: AS in AA with prostate cancer carries higher risk of NOC compared to non-AA population. More stringent AS entrance criteria may be necessary for AA men.

Assessment of inherited DNA repair defects in African-American and Caucasian men with prostate cancer.

2020 ◽  
Vol 38 (6_suppl) ◽  
pp. 185-185
Author(s):  
A. Oliver Sartor ◽  
Shan Yang ◽  
Elisa Marie Ledet ◽  
Marcus W. Moses ◽  
Piper L.W. Nicolosi
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
African American ◽  
San Francisco ◽  
Reliable Data ◽  
Comparative Data ◽  
Caucasian American ◽  
Large Dataset ◽  
Data Set ◽  
Caucasian Men

185 Background: Pathogenic inherited DNA repair defects are well described in Caucasian American (CA) men with prostate cancer (PCa) but comparative data with large subsets of African-American (AA) men are limited. Methods: Herein we examine germline pathogenic/likely pathogenic defects (P/LP) in 14 well annotated genes involved in DNA repair pathways in a large Invitae Corporation (San Francisco) lab-derived dataset of men with PCa. Frequency of P/LP alteration were directly compared in AA men and CA men. Reliable data on metastatic rates, family history, and Gleason score are missing. These data are derived from “real-world” experiences using both academic and private practice sites in accordance with physician ordering practices. The number of men assessed for individual genes aberrations varied. The 14 genes were assessed in 148-213 AA men and 1760-2488 CA men. Results: Comparative data using Invitae assays have lower levels of P/LP DNA repair alterations (as a whole) in the assays from AA men as compared to CA men (7.5% vs 13.9%, P=0.008). The P/LP variants in AA men were BRCA2 (6/214, 2.8%), BRCA1 (3/213, 1.4%), PALB2 (2/182, 1.1%), ATM (2/206, 1.0%), RAD51C (1/148, 0.68%), CHEK2 (1/207, 0.48%), and PMS2 (1/212, 0.47%). No AA men in this data set had P/LP mutations in BARD1, BRIP1, MLH1, MSH2, MSH6, NBN, or RAD51D. Lower frequency of P/LP findings in non-BRCA alterations were notably different in AA men as compared to CA men (0.48% vs 3.11%, P=0.03). The frequency of BRCA P/LP variants was not distinct between the AA and CA men. Additional comparisons show that Invitae CA data set is similar to a well cited previously published metastatic PCa data set. Conclusions: Taken together these data from comparable commercial assays indicate that AA men with PCa in this large dataset have lower rates of germline DNA repair P/LP alterations as compared to CA men. These findings are driven by lower rates of P/LP alterations in the non-BRCA genes.

Abstract A78: Associations between IGF-axis, testosterone and nutrients in healthy African American and Caucasian men at increased risk for prostate cancer

2010 ◽  
Author(s):  
Tanya D. Agurs-Collins ◽  
Kepher Makambi ◽  
Hyunuk Seung ◽  
Bruce J. Trock ◽  
Kevin J. Cullen
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Increased Risk ◽  
Caucasian Men
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