scholarly journals Queratocisto odontogênico agressivo: relato de caso

2020 ◽  
Vol 9 (6) ◽  
pp. 550-552
Author(s):  
Maylson Alves Nogueira Barros ◽  
Vitor Bruno Teslenco ◽  
Diogo Henrique Rodrigues Marques ◽  
Herbert de Abreu Cavalcanti ◽  
Guilherme Nucci Reis ◽  
...  
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Meta Analysis ◽  
Rare Occurrence ◽  
Odontogenic Tumours ◽  
Odontogenic Keratocysts ◽  
Surgical Treatments ◽  
Keratocystic Odontogenic Tumors

Introdução: O queratocisto odontogênico compreende uma lesão cística benigna, de origem dos restos da lamina dentaria ou células epiteliais adjacentes, com altas taxas de recorrência, crescimento rápido no sentido antero-posterior no interior do tecido ósseo medular. Objetivo: Este trabalho tem como objetivo descrever relato de caso de um queratocisto atípico. Relato de Caso: Paciente leucoderma, 17 anos, encaminhando ao serviço de Cirurgia e Traumatologia Bucomaxilofacial devido queixa de aumento de volume, dor, dormência do lábio inferior, mobilidade dentaria. Foi solicitado exame de imagem, uma tomografia de face, onde se evidenciou uma imagem hipodensa, osteolítica, envolvendo região mandibular. O paciente foi diagnostico com queratocisto odontogênico, sendo submetido a tratamento conservador da lesão. Conclusão: O tratamento escolhido foi individualizado e escolhido conforme o embasamento teórico encontrado, levando em consideração todas as complicações. O tratamento proposto foi efetivo até atual momento, e o paciente permanece em acompanhamento clinico e radiográfico, entretanto não indica cura da doença. Descritores: Cistos Ósseos; Patologia Bucal; Mandíbula. Referências Neville BW, Damm DD, Alen CM, Bouquot JE. Patologia oral e maxilofacial. 4.ed. Rio de Janeiro: Elsevier; 2016. Tenorio J, Arias P, Martínez-Glez V, Santos F, García-Miñaur S, Nevado J, Lapunzina P. Simpson-Golabi-Behmel syndrome types I and II. Orphanet J Rare Dis. 2014;9:138.  Sánchez-Burgos R, González-Martín-Moro J, Pérez-Fernández E, Burgueño-García M. Clinical, radiological and therapeutic features of keratocystic odontogenic tumours: a study over a decade. J Clin Exp Dent. 2014;6(3):e259-64. de Castro MS, Caixeta CA, de Carli ML, Ribeiro Júnior NV, Miyazawa M, Pereira AAC, Sperandio FF, Hanemann JAC. Conservative surgical treatments for nonsyndromic odontogenic keratocysts: a systematic review and meta-analysis. Clin Oral Investig. 2018;22(5):2089-2101. Fidele NB, Yueyu Z, Zhao Y, Tianfu W, Liu J, Sun Y, Liu B. Recurrence of odontogenic keratocysts and possible prognostic factors: Review of 455 patients. Med Oral Patol Oral Cir Bucal. 2019;24(4):e491-e501. Chrcanovic BR, Gomez RS. Recurrence probability for keratocystic odontogenic tumors: An analysis of 6427 cases. J Craniomaxillofac Surg. 2017 Feb;45(2):244-51. Jalali E, Ferneini EM, Rengasamy K, Tadinada A. Squamous cell carcinoma arising within a maxillary odontogenic keratocyst: A rare occurrence. Imaging Sci Dent. 2017;47(2):135-40.

Prognostic Factors and Outcomes of De Novo Sinonasal Squamous Cell Carcinoma: A Systematic Review and Meta-analysis

2021 ◽  
pp. 019459982110210
Author(s):  
Emily S. Nguyen ◽  
Adwight Risbud ◽  
Jack L. Birkenbeuel ◽  
Linda S. Murphy ◽  
Khodayar Goshtasbi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Maxillary Sinus ◽  
Squamous Cell ◽  
De Novo ◽  
Meta Analysis ◽  
Hpv Status ◽  
Recurrence Patterns

Objective To review overall survival (OS), recurrence patterns, and prognostic factors of de novo sinonasal squamous cell carcinoma (DN-SCC). Data Sources PubMed, Scopus, OVID Medline, and Cochrane databases from 2006 to December 23, 2020. Review Methods The study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Articles were required to report either recurrence patterns or survival outcomes of adults with DN-SCC. Case reports, books, reviews, meta-analyses, and database studies were all excluded. Results Forty-one studies reported on survival or recurrence outcomes. The aggregate 5-year OS was 54.5% (range, 18%-75%) from 35 studies (n = 1903). Patients undergoing open surgery were more likely to receive radiation therapy and present at an advanced stage compared to those receiving endoscopic surgery (all P < .001). Advanced T stage, presence of cervical nodal metastases, maxillary sinus primary site, and negative human papillomavirus (HPV) status were all correlated with significantly worse 5-year OS. Direct meta-analysis of 8 studies demonstrated patients with surgery were more likely to be alive at 5 years compared to those who did not receive surgery (odds ratio, 2.26; 95% CI, 1.48-3.47; P < .001). Recurrence was reported in 628 of 1471 patients from 26 studies (42.7%) with an aggregate 5-year locoregional control rate of 67.1% (range, 50.4%-93.3%). Conclusion This systematic review and meta-analysis suggests that the 5-year OS rate for DN-SCC may approach 54.5% and recurrence rate approaches 42.7%. In addition, various tumor characteristics including advanced T stage, positive nodal status, maxillary sinus origin, and negative HPV status are all associated with decreased survival.

scholarly journals Tumor-Infiltrating Lymphocytes in the Tumor Microenvironment of Laryngeal Squamous Cell Carcinoma: Systematic Review and Meta-Analysis

Biomedicines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 486
Author(s):  
Juan P. Rodrigo ◽  
Mario Sánchez-Canteli ◽  
Fernando López ◽  
Gregory T. Wolf ◽  
Juan C. Hernández-Prera ◽  
...  
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Tumor Microenvironment ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Meta Analysis ◽  
Tumor Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes

The presence of tumor-infiltrating lymphocytes (TIL) in the tumor microenvironment has been demonstrated to be of prognostic value in various cancers. In this systematic review and meta-analysis, we investigated the prognostic value of TIL in laryngeal squamous cell carcinoma (LSCC). We performed a systematic search in PubMed for publications that investigated the prognostic value of TIL in LSCC. A meta-analysis was performed including all studies assessing the association between TIL counts in hematoxylin-eosin (HE)-stained sections, for CD8+ and/or CD3+/CD4+ TIL and overall survival (OS) or disease-free survival (DFS). The pooled meta-analysis showed a favorable prognostic role for stromal TIL in HE sections for OS (HR 0.57, 95% CI 0.36–0.91, p = 0.02), and for DFS (HR 0.56, 95% CI 0.34–0.94, p = 0.03). High CD8+ TIL were associated with a prolonged OS (HR 0.62, 95% CI 0.4–0.97, p = 0.04) and DFS (HR 0.73, 95% CI 0.34–0.94, p = 0.002). High CD3+/CD4+ TIL demonstrated improved OS (HR 0.32, 95% CI 0.16–0.9, p = 0.03) and DFS (HR 0.23, 95% CI 0.10–0.53, p = 0.0005). This meta-analysis confirmed the favorable prognostic significance of TIL in LSCC. High stromal TIL evaluated in HE sections and intra-tumoral and stromal CD3+, CD4+ and/or CD8+ TIL might predict a better clinical outcome.

Sign in / Sign up

Export Citation Format

Share Document