scholarly journals A clinical case of successful combined treatment of a patient with fibrous cavernous pulmonary tuberculosis and extensive drug resistance

2020 ◽  
Vol 98 (6) ◽  
pp. 52-59
Author(s):  
P. N. Golubchikov ◽  
D. Yu. Schegertsov ◽  
T. I. Melnikovа ◽  
D. V. Krаsnov ◽  
D. A. Skvortsov ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Pulmonary Tuberculosis ◽  
Successful Treatment ◽  
Clinical Case ◽  
Chemotherapy Regimen ◽  
Combined Treatment ◽  
Extensive Drug Resistance

The article describes a clinical case of successful treatment of a patient with disseminated bilateral fibrous cavernous tuberculosis and extensive drug resistance, with preserved sensitivity to only one anti-tuberculosis drug; the fifth chemotherapy regimen and pleuropneumonectomy were used.

scholarly journals A Clinical Case of Extensive Drug Resistant Pulmonary Tuberculosis Using an Endobronchial Valve. Analysis of Errors in the Choice of Chemotherapy Regimen

2021 ◽  
Vol 99 (11) ◽  
pp. 66-71
Author(s):  
I. A. Burmistrovа ◽  
E. V. Ezhovа ◽  
Kh. B. Dаdаshevа ◽  
E. V. Vаniev ◽  
O. V. Lovаchevа ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Pulmonary Tuberculosis ◽  
Clinical Case ◽  
Chemotherapy Regimen ◽  
Total Duration ◽  
Drug Resistant ◽  
Adequate Treatment ◽  
Late Initiation ◽  
Extensive Drug Resistance ◽  
Endobronchial Valve

The article describes a clinical case of a female patient with respiratory tuberculosis exposed to several cases of extensive drug resistance in their family. Tuberculosis progressed in this patient due to the late initiation of adequate treatment. Therefore, the total duration of chemotherapy made 5 years till cure was achieved and an endobronchial valve was used to heal persisting (for 3 years) lung destruction.

scholarly journals MANAGEMENT OF PREGNANCY, DELIVERY AND POST-NATAL PERIOD IN THE PATIENT WITH DRUG RESISTANT DESTRUCTIVE PULMONARY TUBERCULOSIS AFTER SEVERAL SURGERIES

2018 ◽  
Vol 96 (6) ◽  
pp. 58-63
Author(s):  
S. I. Kayukova ◽  
O. G. Komissarova ◽  
N. L. Karpina ◽  
V. V. Romanov ◽  
E. V. Uvarova ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Pulmonary Tuberculosis ◽  
Female Patient ◽  
Clinical Case ◽  
Drug Resistant ◽  
Successful Management ◽  
The Past ◽  
Advanced Form ◽  
Extensive Drug Resistance

The article describes a clinical case of the successful management of pregnancy, delivery and post-natal period in the female patient with fibrous cavernous tuberculosis with extensive drug resistance and multiple thoracic surgeries in the past. This clinical case demonstrates that it is possible for a mother with the advanced form of tuberculosis to give birth to a healthy mature newborn.

scholarly journals Factors affecting successful treatment outcomes in pulmonary tuberculosis: a single-center experience in Turkey, 2005–2011

2015 ◽  
Vol 9 (08) ◽  
pp. 821-828 ◽  
Author(s):  
Aysun Sengul ◽  
Ulku Aka Akturk ◽  
Yusuf Aydemir ◽  
Nurullah Kaya ◽  
Nagihan Durmus Kocak ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Treatment Outcome ◽  
Pulmonary Tuberculosis ◽  
Treatment Failure ◽  
Treatment Outcomes ◽  
Successful Treatment ◽  
Treatment Success ◽  
Previous Treatment ◽  
Factors Affecting ◽  
Treatment Default

Introduction: We aimed to describe the treatment outcomes in patients with bacteriologically confirmed pulmonary tuberculosis (PTB) and identify factors associated with successful treatment outcome. Methodology: The medical charts of patients with smear and/or culture-positive PTB who were treated between 2005 and 2011 at the Kocaeli Tuberculosis Dispensary, Turkey, were reviewed. Patients were categorized as having a successful (cured or with a completed treatment) or poor (treatment default, treatment failure, death) treatment outcome. The association of demographic and clinical factors, including gender, age, education, occupation, insurance, family size, living area, smear and culture positivity, retreatment, comorbidity, drug resistance, and cavity on radiography, with the success of treatment, was evaluated by univariate and multivariate analyses. Results: Of 738 patients (258 females, 480 males) with bacteriologically confirmed PTB, 683 (92.6%) had successful treatment outcomes. Of those with a poor outcome, 29 (3.9%) had treatment default, 18 (2.4%) died, and 8 (1.1%) had treatment failure. Young age, no previous treatment, no comorbidity, no drug resistance, and high education level were factors significantly associated with successful PTB treatment outcome (p < 0.05 for all). Conclusions: Treatment outcome was successful in young and educated PTB patients who had drug resistance, previous treatment history, and no comorbidities. Knowledge of the factors affecting treatment success will lead to the undertaking of specific measures in the management of PTB, which may help to decrease treatment failure.

scholarly journals A CLINICAL CASE OF EFFECTIVE TREATMENT OF EXTENSIVE DRUG RESISTANCE TUBERCULOSIS WITH NEW ANTI-TUBERCULOSIS DRUGS

2017 ◽  
Vol 95 (12) ◽  
pp. 58-62
Author(s):  
M. V. Pavlova ◽  
◽  
E. S. Ershova ◽  
N. V. Sapozhnikova ◽  
A. A. Starshinova ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Effective Treatment ◽  
Clinical Case ◽  
Extensive Drug Resistance

Clinical case of successful treatment of compartment syndrome, complicated by fat embolism syndrome

2018 ◽  
Vol 16 (7(part 1)) ◽  
pp. 81-84
Author(s):  
I. O. Pankov ◽  
◽  
M. M. Gabdullin ◽  
S. D. Sirazitdinov ◽  
◽  
...  
Keyword(s):  
Compartment Syndrome ◽  
Successful Treatment ◽  
Clinical Case ◽  
Fat Embolism ◽  
Fat Embolism Syndrome ◽  
Embolism Syndrome

Are Carbonic Anhydrases Suitable Targets to Fight Protozoan Parasitic Diseases?

2019 ◽  
Vol 25 (39) ◽  
pp. 5266-5278 ◽  
Author(s):  
Katia D'Ambrosio ◽  
Claudiu T. Supuran ◽  
Giuseppina De Simone
Keyword(s):  
Drug Resistance ◽  
Animal Models ◽  
Carbonic Anhydrase ◽  
Drug Target ◽  
Treatment Options ◽  
Parasitic Diseases ◽  
Carbonic Anhydrases ◽  
Extensive Drug Resistance ◽  
Protozoan Infections

Protozoans belonging to Plasmodium, Leishmania and Trypanosoma genera provoke widespread parasitic diseases with few treatment options and many of the clinically used drugs experiencing an extensive drug resistance phenomenon. In the last several years, the metalloenzyme Carbonic Anhydrase (CA, EC 4.2.1.1) was cloned and characterized in the genome of these protozoa, with the aim to search for a new drug target for fighting malaria, leishmaniasis and Chagas disease. P. falciparum encodes for a CA (PfCA) belonging to a novel genetic family, the η-CA class, L. donovani chagasi for a β-CA (LdcCA), whereas T. cruzi genome contains an α-CA (TcCA). These three enzymes were characterized in detail and a number of in vitro potent and selective inhibitors belonging to the sulfonamide, thiol, dithiocarbamate and hydroxamate classes were discovered. Some of these inhibitors were also effective in cell cultures and animal models of protozoan infections, making them of considerable interest for the development of new antiprotozoan drugs with a novel mechanism of action.

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