A CLINICAL CASE OF EFFECTIVE TREATMENT OF EXTENSIVE DRUG RESISTANCE TUBERCULOSIS WITH NEW ANTI-TUBERCULOSIS DRUGS

The article describes a clinical case of the successful management of pregnancy, delivery and post-natal period in the female patient with fibrous cavernous tuberculosis with extensive drug resistance and multiple thoracic surgeries in the past. This clinical case demonstrates that it is possible for a mother with the advanced form of tuberculosis to give birth to a healthy mature newborn.

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A clinical case of successful combined treatment of a patient with fibrous cavernous pulmonary tuberculosis and extensive drug resistance

Tuberculosis and lung diseases ◽

10.21292/2075-1230-2020-98-6-52-59 ◽

2020 ◽

Vol 98 (6) ◽

pp. 52-59

Author(s):

P. N. Golubchikov ◽

D. Yu. Schegertsov ◽

T. I. Melnikovа ◽

D. V. Krаsnov ◽

D. A. Skvortsov ◽

...

Keyword(s):

Drug Resistance ◽

Pulmonary Tuberculosis ◽

Successful Treatment ◽

Clinical Case ◽

Chemotherapy Regimen ◽

Combined Treatment ◽

Extensive Drug Resistance

The article describes a clinical case of successful treatment of a patient with disseminated bilateral fibrous cavernous tuberculosis and extensive drug resistance, with preserved sensitivity to only one anti-tuberculosis drug; the fifth chemotherapy regimen and pleuropneumonectomy were used.

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A Clinical Case of Extensive Drug Resistant Pulmonary Tuberculosis Using an Endobronchial Valve. Analysis of Errors in the Choice of Chemotherapy Regimen

Tuberculosis and lung diseases ◽

10.21292/2075-1230-2021-99-11-66-71 ◽

2021 ◽

Vol 99 (11) ◽

pp. 66-71

Author(s):

I. A. Burmistrovа ◽

E. V. Ezhovа ◽

Kh. B. Dаdаshevа ◽

E. V. Vаniev ◽

O. V. Lovаchevа ◽

...

Keyword(s):

Drug Resistance ◽

Pulmonary Tuberculosis ◽

Clinical Case ◽

Chemotherapy Regimen ◽

Total Duration ◽

Drug Resistant ◽

Adequate Treatment ◽

Late Initiation ◽

Extensive Drug Resistance ◽

Endobronchial Valve

The article describes a clinical case of a female patient with respiratory tuberculosis exposed to several cases of extensive drug resistance in their family. Tuberculosis progressed in this patient due to the late initiation of adequate treatment. Therefore, the total duration of chemotherapy made 5 years till cure was achieved and an endobronchial valve was used to heal persisting (for 3 years) lung destruction.

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Are Carbonic Anhydrases Suitable Targets to Fight Protozoan Parasitic Diseases?

Current Medicinal Chemistry ◽

10.2174/0929867325666180326160121 ◽

2019 ◽

Vol 25 (39) ◽

pp. 5266-5278 ◽

Cited By ~ 9

Author(s):

Katia D'Ambrosio ◽

Claudiu T. Supuran ◽

Giuseppina De Simone

Keyword(s):

Drug Resistance ◽

Animal Models ◽

Carbonic Anhydrase ◽

Drug Target ◽

Treatment Options ◽

Parasitic Diseases ◽

Carbonic Anhydrases ◽

Extensive Drug Resistance ◽

Protozoan Infections

Protozoans belonging to Plasmodium, Leishmania and Trypanosoma genera provoke widespread parasitic diseases with few treatment options and many of the clinically used drugs experiencing an extensive drug resistance phenomenon. In the last several years, the metalloenzyme Carbonic Anhydrase (CA, EC 4.2.1.1) was cloned and characterized in the genome of these protozoa, with the aim to search for a new drug target for fighting malaria, leishmaniasis and Chagas disease. P. falciparum encodes for a CA (PfCA) belonging to a novel genetic family, the η-CA class, L. donovani chagasi for a β-CA (LdcCA), whereas T. cruzi genome contains an α-CA (TcCA). These three enzymes were characterized in detail and a number of in vitro potent and selective inhibitors belonging to the sulfonamide, thiol, dithiocarbamate and hydroxamate classes were discovered. Some of these inhibitors were also effective in cell cultures and animal models of protozoan infections, making them of considerable interest for the development of new antiprotozoan drugs with a novel mechanism of action.

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Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer

Cells ◽

10.3390/cells10071715 ◽

2021 ◽

Vol 10 (7) ◽

pp. 1715

Author(s):

Macus Hao-Ran Bao ◽

Carmen Chak-Lui Wong

Keyword(s):

Hepatocellular Carcinoma ◽

Drug Resistance ◽

Liver Cancer ◽

Effective Treatment ◽

Molecular Mechanisms ◽

Hypoxia Inducible Factor ◽

Metabolic Reprogramming ◽

Combination Therapies ◽

Low Oxygen ◽

Treatment Regimens

Hypoxia, low oxygen (O2) level, is a hallmark of solid cancers, especially hepatocellular carcinoma (HCC), one of the most common and fatal cancers worldwide. Hypoxia contributes to drug resistance in cancer through various molecular mechanisms. In this review, we particularly focus on the roles of hypoxia-inducible factor (HIF)-mediated metabolic reprogramming in drug resistance in HCC. Combination therapies targeting hypoxia-induced metabolic enzymes to overcome drug resistance will also be summarized. Acquisition of drug resistance is the major cause of unsatisfactory clinical outcomes of existing HCC treatments. Extra efforts to identify novel mechanisms to combat refractory hypoxic HCC are warranted for the development of more effective treatment regimens for HCC patients.

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Advanced strategies for development of vaccines against human bacterial pathogens

World Journal of Microbiology and Biotechnology ◽

10.1007/s11274-021-03021-6 ◽

2021 ◽

Vol 37 (4) ◽

Author(s):

Abhinay Sharma ◽

Pooja Sanduja ◽

Aparna Anand ◽

Pooja Mahajan ◽

Carlos A. Guzman ◽

...

Keyword(s):

Drug Resistance ◽

Infectious Diseases ◽

Effective Treatment ◽

Bacterial Pathogens ◽

Vaccine Design ◽

Human Beings ◽

Rational Vaccine Design ◽

New Vaccines

AbstractInfectious diseases are one of the main grounds of death and disabilities in human beings globally. Lack of effective treatment and immunization for many deadly infectious diseases and emerging drug resistance in pathogens underlines the need to either develop new vaccines or sufficiently improve the effectiveness of currently available drugs and vaccines. In this review, we discuss the application of advanced tools like bioinformatics, genomics, proteomics and associated techniques for a rational vaccine design.

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Emergence of Extensive Drug Resistance during Treatment for Multidrug-Resistant Tuberculosis

New England Journal of Medicine ◽

10.1056/nejmc0805644 ◽

2008 ◽

Vol 359 (22) ◽

pp. 2398-2400 ◽

Cited By ~ 35

Author(s):

Helen S. Cox ◽

Caterina Sibilia ◽

Silke Feuerriegel ◽

Stobdan Kalon ◽

Jonny Polonsky ◽

...

Keyword(s):

Drug Resistance ◽

Multidrug Resistant ◽

Resistant Tuberculosis ◽

Multidrug Resistant Tuberculosis ◽

Extensive Drug Resistance

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Surgical treatment of pulmonary tuberculosis in patients with concurrent parenteral viral hepatitis

Tuberculosis and lung diseases ◽

10.21292/2075-1230-2020-98-6-22-26 ◽

2020 ◽

Vol 98 (6) ◽

pp. 22-26

Author(s):

S. N. Shugаevа ◽

А. E. Suzdаlnitskiy ◽

E. D. Sаvilov ◽

S. I. Mаlov ◽

I. V. Mаlov

Keyword(s):

Drug Resistance ◽

Surgical Treatment ◽

Viral Hepatitis ◽

Hepatitis Virus ◽

Small Scale ◽

Surgical Interventions ◽

Tuberculosis Patients ◽

Continuous Sampling ◽

Extensive Drug Resistance ◽

Chronic Course

The objective: to assess the effect of parenteral viral hepatitis on the manifestations of respiratory tuberculosis and the nature of surgical interventions for tuberculosis.Subjects and methods. An ambispective observational study was conducted with a continuous sampling of 475 respiratory tuberculosis patients over 18 years old who underwent surgical interventions. The patients are divided into two groups: the group of RTB+PVH consisted of 92 patients with concurrent respiratory tuberculosis and chronic parenteral viral hepatitis; the group of RTB included 383 patients with respiratory tuberculosis and no parenteral viral hepatitis.Results. It was found that compared with RTB group, in RTB+PVH group (regardless of the type of hepatitis virus), a chronic course of tuberculosis was registered significantly more often (42.4%; p = 0.005; OS = 2.0); more often bacillary excretion was documented (68.5%; p = 0.035; OR = 1.7), including those with multiple and extensive drug resistance (52.4% of cases with positive sputum tests, p = 0.048; OR = 1.8). Radical (69.6%; p = 0.05; OS = 1.7) and small-scale surgical interventions (64.1%; p = 0.037; OS = 1.8) were significantly less frequently performed in RTB+PVH patients; and such patients often developed postoperative complications (8.7%; p = 0.009; OS = 2.9).

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Characterization of Mutations Conferring Extensive Drug Resistance to Mycobacterium tuberculosis Isolates in Pakistan

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.05101-11 ◽

2011 ◽

Vol 55 (12) ◽

pp. 5654-5659 ◽

Cited By ~ 31

Author(s):

Asho Ali ◽

Rumina Hasan ◽

Kauser Jabeen ◽

Nusrat Jabeen ◽

Ejaz Qadeer ◽

...

Keyword(s):

Drug Resistance ◽

Mycobacterium Tuberculosis ◽

Hot Spot ◽

East African ◽

Content Type ◽

Diagnostic Assays ◽

Asian Strain ◽

Central Asian ◽

Extensive Drug Resistance ◽

Detection Of Mutations

ABSTRACTThe increasing incidence of extensively drug-resistant (XDR)Mycobacterium tuberculosisin high-tuberculosis-burden countries further highlights the need for improved rapid diagnostic assays. An increasing incidence of XDRM. tuberculosisstrains in Pakistan has been reported, but drug resistance-associated mutations in these strains have not been evaluated previously. We sequenced the “hot-spot” regions ofrpoB,katG,inhA,ahpC,gyrA,gyrB, andrrsgenes in 50 XDRM. tuberculosisstrains. It was observed that 2% of rifampin, 6% of isoniazid, 24% of fluoroquinolone, and 32% of aminoglycoside/capreomycin resistance in XDRM. tuberculosisstrains would be undetected if only these common hot-spot regions were tested. The frequencies of resistance-conferring mutations were found to be comparable among all XDRM. tuberculosisstrain families present, including the Central Asian Strain, Beijing, and East African Indian genogroups and the Unique isolates. Additional genetic loci need to be tested for detection of mutations conferring fluoroquinolone, aminoglycoside, and capreomycin resistance in order to improve molecular diagnosis of regional XDRM. tuberculosisstrains.

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