scholarly journals Thrombotic Thrombocytopenic Purpura as a Rare Etiopathogenetic Cause of Cerebral Infarction and Extracerebral Thrombosis

2021 ◽  
Vol 18 (4) ◽  
pp. 90-94
Author(s):  
А. R. Аvidzba ◽  
V. A. Saskin ◽  
E. V. Nedashkovskiy
Keyword(s):  
Clinical Practice ◽  
Early Diagnosis ◽  
Cerebral Infarction ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Clinical Case ◽  
Specific Treatment ◽  
Thrombotic Microangiopathies ◽  
Timely Initiation ◽  
Thrombocytopenic Purpura ◽  
Real Challenge

Thrombotic thrombocytopenic purpura is a disease from the group of thrombotic microangiopathies, the early diagnosis of which is a real challenge in clinical practice. The article presents a clinical case that clearly illustrates the multisystem nature of the damage against the background of thrombotic microangiopathy, specific parameters of diagnosis, and emergency therapy Timely initiation of specific treatment significantly increases the chances of survival in this category of patients.

Purple Thrombocytopenic Thrombotic

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Lina Marcela Roncallo
Keyword(s):  
Thrombotic Thrombocytopenic Purpura ◽  
Clinical Picture ◽  
Clinical Case ◽  
Vital Signs ◽  
Peripheral Blood Smear ◽  
Success Rates ◽  
Thrombotic Microangiopathies ◽  
Diagnostic Challenge ◽  
Thrombocytopenic Purpura ◽  
Serum Haptoglobin

Thrombotic thrombocytopenic purpura is a rare disease of immune origin, belonging to thrombotic microangiopathies. In most cases, it can present as microangiopathic hemolytic anemia accompanied by thrombocytopenia, neurological deficit and kidney abnormalities. The present clinical case belongs to a female patient with no significant personal or family history, who went to the doctor for a clinical picture of 2 days of evolution with hematuria, general malaise, asthenia and adynamia, on physical examination without alterations, with vital signs in ranges of normality. The diagnosis of thrombotic thrombocytopenic purpura was made due to hemolysis, elevated levels of lactate dehydrogenase and a reduction in serum haptoglobin accompanied by the presence of serum schistocytes> 6% in the peripheral blood smear. Thrombocytopenic purpura is a diagnostic challenge because its clinical picture is often nonspecific, making it more difficult to start its treatment in a timely manner. Another drawback is the high costs for ADAMTS13 activity tests. Despite the fact that the treatments for this disease have low success rates, in our clinical case our patient responded favorably to the treatment instituted

scholarly journals The PLASMIC Score May Be Useful in the Early Diagnosis of Complement-Mediated Thrombotic Microangiopathy via Early Exclusion of Thrombotic Thrombocytopenic Purpura

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
Edwin Lu ◽  
Willie Moore
Keyword(s):  
Early Diagnosis ◽  
Effective Treatment ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Thrombotic Microangiopathy ◽  
Rapid Diagnosis ◽  
Thrombotic Microangiopathies ◽  
Rare Form ◽  
Thrombocytopenic Purpura ◽  
Mortality And Morbidity ◽  
Scoring Model

Complement-mediated thrombotic microangiopathy is a rare form of thrombotic microangiopathy but has high rates of mortality and morbidity. Effective treatment exists with eculizumab for this condition, but administration of treatment is often delayed because of overlapping symptoms with other causes of thrombotic microangiopathy. We present a case of a 78-year-old male who was eventually diagnosed with complement-mediated thrombotic microangiopathy. We also discuss the use of the PLASMIC scoring model to assist in more rapid diagnosis and discernment between various thrombotic microangiopathies.

scholarly journals Current insights into thrombotic microangiopathies: Thrombotic thrombocytopenic purpura and pregnancy

2015 ◽  
Vol 135 ◽  
pp. S30-S33 ◽  
Author(s):  
Charis von Auer ◽  
Anne-Sophie von Krogh ◽  
Johanna A. Kremer Hovinga ◽  
Bernhard Lämmle
Keyword(s):  
Thrombotic Thrombocytopenic Purpura ◽  
Thrombotic Microangiopathies ◽  
Thrombocytopenic Purpura

scholarly journals Pregnancy onset congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome) mimicking HELLP syndrome: a case report

2021 ◽  
Vol 29 (3) ◽  
pp. 270-273
Author(s):  
Başak Ergin ◽  
Berna Buse Kobal ◽  
Zeynep Yazıcı ◽  
Ali Hakan Kaya ◽  
Sezin Canbek ◽  
...  
Keyword(s):  
Thrombotic Thrombocytopenic Purpura ◽  
Hellp Syndrome ◽  
Epigastric Pain ◽  
Novel Mutation ◽  
Adamts13 Activity ◽  
Thrombotic Microangiopathies ◽  
Thrombocytopenic Purpura ◽  
Uremic Syndrome ◽  
Congenital Thrombotic Thrombocytopenic Purpura ◽  
Low Platelet Count

Objective Thrombotic thrombocytopenic purpura is a thrombotic microangiopathic condition characterized by hemolytic anemia, thrombocytopenia, neurologic abnormalities, fever and renal dysfunction. Thrombotic microangiopathies such as preeclampsia and HELLP syndrome are pregnancy-specific, whereas others such as thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome are not. In this report, we present a case at which we identified a novel mutation which led to a significant reduction of ADAMTS13 activity. Case(s) A nulliparous pregnant woman of 32-year-old presenting with epigastric pain, hypertension and low platelet count was first suspected of HELLP syndrome, but was diagnosed with congenital TTP after delivery. Conclusion HELLP syndrome co-existed with undiagnosed TTP in this case. We strive to have sufficient awareness in order to distinguish these two pathologies from each other on an antenatal basis, because the causes of the managements are entirely different.

scholarly journals CASE OF SECONDARY THROMBOTIC THROMBOCYTOPENIC PURPURA TRIGGERED BY COVID-19

2021 ◽  
Vol 19 (5) ◽  
pp. 541-545
Author(s):  
R. E. Yakubtsevich ◽  
◽  
Ye. V. Zukhovitskaya ◽  
K. M. Dorokhin ◽  
N. F. Vasilevskaya ◽  
...  
Keyword(s):  
Effective Treatment ◽  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Clinical Case ◽  
Thrombocytopenic Purpura

The article analyzes a clinical case of the development of thrombotic thrombocytopenic purpura (TTP) in a patient with verified COVID-19 infection. The algorithm of TTP diagnosis when ADAMTS13 biomarker test is unavailable is presented. The article presents the scheme of effective treatment of TTP with the use of plasma exchange, methylprednisolone and rituximab administration.

scholarly journals Four Cases of Thrombotic Thrombocytopenic Purpura with Poor Prognsosis Despite Early Diagnosis

2007 ◽  
Vol 56 (4) ◽  
pp. 117-123
Author(s):  
Mayumi ADACHI ◽  
Kumiko MATSUI ◽  
Kazuhiro MATSUDA ◽  
Kenji SHINOHARA
Keyword(s):  
Early Diagnosis ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Thrombocytopenic Purpura

scholarly journals COVID-19 and Thrombotic Thrombocytopenic Purpura: A Case Report

2021 ◽  
Author(s):  
Maryam Darnahal ◽  
Hamed Azhdari Tehrani ◽  
Mohammad Vaezi ◽  
Shirin Haghighi
Keyword(s):  
Case Report ◽  
Blood Cell ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Organ Dysfunction ◽  
Red Blood Cell ◽  
Immune Complexes ◽  
Cell Injury ◽  
Coagulation Cascade ◽  
Thrombotic Microangiopathies ◽  
Thrombocytopenic Purpura

Endothelial injury by toxins, drugs, immune complexes leads to activation of coagulation cascade and thrombosis, which result in platelet consumption and red blood cell injury. These thrombotic microangiopathies can potentially injure numerous organs and result in organ dysfunction. In this case, we present the fourth reported patient with thrombotic thrombocytopenic purpura associated with COVID-19.

Microangiopathic and Vascular Disorders

2020 ◽  
Author(s):  
Nathan T. Connell
Keyword(s):  
Thrombotic Thrombocytopenic Purpura ◽  
Diagnostic Criteria ◽  
Antiphospholipid Syndrome ◽  
Disseminated Intravascular Coagulation ◽  
Hereditary Hemorrhagic Telangiectasia ◽  
Thrombotic Microangiopathies ◽  
Thrombocytopenic Purpura ◽  
Vascular Disorders ◽  
Intravascular Coagulation ◽  
Presenting Symptoms

The thrombotic microangiopathies are characterized by microangiopathic hemolytic anemia and thrombocytopenia and can be classified as autoimmune, drug induced, complement mediated, and infectious/other. Reaching a definitive diagnosis for these disorders can be challenging due to the similarity of presenting symptoms and laboratory findings. Specific disorders described in this review include thrombotic thrombocytopenic purpura, the hemolytic-uremic syndrome, thrombotic microangiopathies of pregnancy (including preeclampsia and HELLP syndrome), disseminated intravascular coagulation, and antiphospholipid syndrome. Vascular disorders that lead to hematologic abnormalities are also discussed. Figures show the major classifications of the thrombotic microangiopathies; ADAMTS13 activity in normal and thrombotic thrombocytopenic purpura plasma; a fragmented red blood cell (arrow), also known as a schistocyte or helmet cell; major considerations in the initial treatment of thrombotic thrombocytopenic purpura and options for refractory patients as well as treatment considerations after discontinuation of plasma exchange; and a diagram of the complement pathway showing regulatory proteins as well as the site of action for the monoclonal antibody eculizumab. Tables list medications associated with thrombotic thrombocytopenia purpura, diagnostic criteria for HELLP, major classifications and examples of the causes of disseminated intravascular coagulation, diagnostic criteria for the antiphospholipid syndrome, vascular purpuras, and criteria for diagnosing hereditary hemorrhagic telangiectasia. This review contains 5 highly rendered figures, 10 tables, and 74 references Key words: anemia, hereditary hemorrhagic telangiectasia,thrombotic microangiopathies, thrombotic Thrombocytopenic Purpura, von Willebrand factor

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