Purple Thrombocytopenic Thrombotic

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Lina Marcela Roncallo
Keyword(s):  
Thrombotic Thrombocytopenic Purpura ◽  
Clinical Picture ◽  
Clinical Case ◽  
Vital Signs ◽  
Peripheral Blood Smear ◽  
Success Rates ◽  
Thrombotic Microangiopathies ◽  
Diagnostic Challenge ◽  
Thrombocytopenic Purpura ◽  
Serum Haptoglobin

Thrombotic thrombocytopenic purpura is a rare disease of immune origin, belonging to thrombotic microangiopathies. In most cases, it can present as microangiopathic hemolytic anemia accompanied by thrombocytopenia, neurological deficit and kidney abnormalities. The present clinical case belongs to a female patient with no significant personal or family history, who went to the doctor for a clinical picture of 2 days of evolution with hematuria, general malaise, asthenia and adynamia, on physical examination without alterations, with vital signs in ranges of normality. The diagnosis of thrombotic thrombocytopenic purpura was made due to hemolysis, elevated levels of lactate dehydrogenase and a reduction in serum haptoglobin accompanied by the presence of serum schistocytes> 6% in the peripheral blood smear. Thrombocytopenic purpura is a diagnostic challenge because its clinical picture is often nonspecific, making it more difficult to start its treatment in a timely manner. Another drawback is the high costs for ADAMTS13 activity tests. Despite the fact that the treatments for this disease have low success rates, in our clinical case our patient responded favorably to the treatment instituted

scholarly journals Thrombotic Thrombocytopenic Purpura as a Rare Etiopathogenetic Cause of Cerebral Infarction and Extracerebral Thrombosis

2021 ◽  
Vol 18 (4) ◽  
pp. 90-94
Author(s):  
А. R. Аvidzba ◽  
V. A. Saskin ◽  
E. V. Nedashkovskiy
Keyword(s):  
Clinical Practice ◽  
Early Diagnosis ◽  
Cerebral Infarction ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Clinical Case ◽  
Specific Treatment ◽  
Thrombotic Microangiopathies ◽  
Timely Initiation ◽  
Thrombocytopenic Purpura ◽  
Real Challenge

Thrombotic thrombocytopenic purpura is a disease from the group of thrombotic microangiopathies, the early diagnosis of which is a real challenge in clinical practice. The article presents a clinical case that clearly illustrates the multisystem nature of the damage against the background of thrombotic microangiopathy, specific parameters of diagnosis, and emergency therapy Timely initiation of specific treatment significantly increases the chances of survival in this category of patients.

scholarly journals Current insights into thrombotic microangiopathies: Thrombotic thrombocytopenic purpura and pregnancy

2015 ◽  
Vol 135 ◽  
pp. S30-S33 ◽  
Author(s):  
Charis von Auer ◽  
Anne-Sophie von Krogh ◽  
Johanna A. Kremer Hovinga ◽  
Bernhard Lämmle
Keyword(s):  
Thrombotic Thrombocytopenic Purpura ◽  
Thrombotic Microangiopathies ◽  
Thrombocytopenic Purpura

The occurrence of thrombotic thrombocytopenic purpura during treatment of HCV with direct-acting antiviral agents

2018 ◽  
Vol 1 (1) ◽  
pp. 1-9
Author(s):  
Amr Hanafy ◽  
◽  
Waseem Seleem ◽  
Salem Mohamed ◽  
Keyword(s):  
Thrombotic Thrombocytopenic Purpura ◽  
Hemolytic Anemia ◽  
Peripheral Blood Smear ◽  
Hcv Infection ◽  
Severe Thrombocytopenia ◽  
Direct Acting Antivirals ◽  
Thrombocytopenic Purpura ◽  
Direct Acting Antiviral ◽  
Chronic Hcv ◽  
Direct Acting

Background and aim Experts have reported thrombocytopenia linked to chronic liver disease in up to 70% in patients with advanced fibrosis and portal hypertension. Thrombotic thrombocytopenic purpura (TTP) occurrence with HCV infection is a rare and life-threatening event. We aimed to investigate the cause of disturbed conscious level, acute hemolytic anemia, and severe thrombocytopenia in a male patient with chronic HCV and under treatment with direct-acting antivirals. Case report: Development of severe thrombocytopenia, acute hemolytic anemia, neurological symptoms in the form of fits and coma in a 32- year- old man with chronic HCV infection after one week of treatment with direct-acting antivirals (sofosbuvir 400mg PO daily, and daclatasvir 60 mg PO daily). Brain CT was normal, with a negative Coombs test and the presence of schistocytes in the peripheral blood smear. The patient presentation was suggestive of thrombotic thrombocytopenic purpura (TTP). Conclusion: This is a case of TTP after one week of direct-acting antiviral drugs despite the safety profile of these medications. Studying the pathophysiology of TTP after DAAs needs more clarifications.

scholarly journals Pregnancy onset congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome) mimicking HELLP syndrome: a case report

2021 ◽  
Vol 29 (3) ◽  
pp. 270-273
Author(s):  
Başak Ergin ◽  
Berna Buse Kobal ◽  
Zeynep Yazıcı ◽  
Ali Hakan Kaya ◽  
Sezin Canbek ◽  
...  
Keyword(s):  
Thrombotic Thrombocytopenic Purpura ◽  
Hellp Syndrome ◽  
Epigastric Pain ◽  
Novel Mutation ◽  
Adamts13 Activity ◽  
Thrombotic Microangiopathies ◽  
Thrombocytopenic Purpura ◽  
Uremic Syndrome ◽  
Congenital Thrombotic Thrombocytopenic Purpura ◽  
Low Platelet Count

Objective Thrombotic thrombocytopenic purpura is a thrombotic microangiopathic condition characterized by hemolytic anemia, thrombocytopenia, neurologic abnormalities, fever and renal dysfunction. Thrombotic microangiopathies such as preeclampsia and HELLP syndrome are pregnancy-specific, whereas others such as thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome are not. In this report, we present a case at which we identified a novel mutation which led to a significant reduction of ADAMTS13 activity. Case(s) A nulliparous pregnant woman of 32-year-old presenting with epigastric pain, hypertension and low platelet count was first suspected of HELLP syndrome, but was diagnosed with congenital TTP after delivery. Conclusion HELLP syndrome co-existed with undiagnosed TTP in this case. We strive to have sufficient awareness in order to distinguish these two pathologies from each other on an antenatal basis, because the causes of the managements are entirely different.

THROMBOTIC THROMBOCYTOPENIC PURPURA: A DIAGNOSTIC CHALLENGE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

2021 ◽  
Author(s):  
Rubens Bonfiglioli ◽  
Vanessa Félix Nascimento Coelho ◽  
Andreza Lamonica ◽  
Thais de Campos Ferreira Pinto
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Diagnostic Challenge ◽  
Thrombocytopenic Purpura

, , , ,

scholarly journals CASE OF SECONDARY THROMBOTIC THROMBOCYTOPENIC PURPURA TRIGGERED BY COVID-19

2021 ◽  
Vol 19 (5) ◽  
pp. 541-545
Author(s):  
R. E. Yakubtsevich ◽  
◽  
Ye. V. Zukhovitskaya ◽  
K. M. Dorokhin ◽  
N. F. Vasilevskaya ◽  
...  
Keyword(s):  
Effective Treatment ◽  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Clinical Case ◽  
Thrombocytopenic Purpura

The article analyzes a clinical case of the development of thrombotic thrombocytopenic purpura (TTP) in a patient with verified COVID-19 infection. The algorithm of TTP diagnosis when ADAMTS13 biomarker test is unavailable is presented. The article presents the scheme of effective treatment of TTP with the use of plasma exchange, methylprednisolone and rituximab administration.

scholarly journals COVID-19 and Thrombotic Thrombocytopenic Purpura: A Case Report

2021 ◽  
Author(s):  
Maryam Darnahal ◽  
Hamed Azhdari Tehrani ◽  
Mohammad Vaezi ◽  
Shirin Haghighi
Keyword(s):  
Case Report ◽  
Blood Cell ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Organ Dysfunction ◽  
Red Blood Cell ◽  
Immune Complexes ◽  
Cell Injury ◽  
Coagulation Cascade ◽  
Thrombotic Microangiopathies ◽  
Thrombocytopenic Purpura

Endothelial injury by toxins, drugs, immune complexes leads to activation of coagulation cascade and thrombosis, which result in platelet consumption and red blood cell injury. These thrombotic microangiopathies can potentially injure numerous organs and result in organ dysfunction. In this case, we present the fourth reported patient with thrombotic thrombocytopenic purpura associated with COVID-19.

Sign in / Sign up

Export Citation Format

Share Document