High Protein-Diet Induced Renal Hyperfiltration is Associated with Rapid Decline Rate of Renal Function: Community Based Prospective Cohort Study

2018 ◽  
Author(s):  
Jong Hyun Jhee ◽  
Youn Kyung Kee ◽  
Seohyun Park ◽  
Hyoungnae Kim ◽  
Jung Tak Park ◽  
...  
Keyword(s):  
Renal Function ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
High Protein Diet ◽  
Protein Diet ◽  
Rapid Decline ◽  
Community Based ◽  
Renal Hyperfiltration ◽  
Decline Rate

scholarly journals High-protein diet with renal hyperfiltration is associated with rapid decline rate of renal function: a community-based prospective cohort study

2019 ◽  
Author(s):  
Jong Hyun Jhee ◽  
Youn Kyung Kee ◽  
Seohyun Park ◽  
Hyoungnae Kim ◽  
Jung Tak Park ◽  
...  
Keyword(s):  
Renal Function ◽  
Protein Intake ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Rapid Decline ◽  
Community Based ◽  
Increased Risk ◽  
Decline Rate ◽  
Egfr Decline

Abstract Background The effect of a high-protein diet with renal hyperfiltration (RHF) on decline of kidney function has rarely been explored. We investigated the association between a high-protein diet, RHF and declining kidney function. Methods A total of 9226 subjects from the Korean Genome and Epidemiology Study, a community-based prospective study (2001–14), were enrolled and classified into quartiles according to daily amount of protein intake based on food frequency questionnaires. RHF was defined as estimated glomerular filtration rate (eGFR) with residuals of >95th percentile after adjustment for age, sex, history of hypertension or diabetes, height and weight. Rapid decline of renal function was defined as decline rate of eGFR >3 mL/min/1.73 m2/year. Results The relative risk of RHF was 3.48-fold higher in the highest than in the lowest protein intake quartile after adjustment for confounding factors [95% confidence interval (CI) 1.39–8.71]. The mean eGFR decline rate was faster as quartiles of protein intake increased. Furthermore, the highest quartile was associated with 1.32-fold increased risk of rapid eGFR decline (95% CI 1.02–1.73). When subjects were divided into two groups with or without RHF, the highest quartile was associated with a rapid decline in renal function only in RHF subjects (odds ratio 3.35; 95% CI 1.07–10.51). The sensitivity analysis using the Korean National Health and Nutrition Examination Survey (2008–15) data with 40 113 subjects showed that higher quartile was associated with increased risk for RHF. Conclusions A high-protein diet increases the risk of RHF and a rapid renal function decline in the general population. These findings suggest that a high-protein diet has a deleterious effect on renal function in the general population.

scholarly journals Low carbohydrate-high protein diet and incidence of cardiovascular diseases in Swedish women: prospective cohort study

BMJ ◽  
2012 ◽  
Vol 344 (jun26 3) ◽  
pp. e4026-e4026 ◽  
Author(s):  
P. Lagiou ◽  
S. Sandin ◽  
M. Lof ◽  
D. Trichopoulos ◽  
H.-O. Adami ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cardiovascular Diseases ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Low Carbohydrate

scholarly journals Low-carbohydrate, high-protein diet score and risk of incident cancer; a prospective cohort study

2013 ◽  
Vol 12 (1) ◽  
Author(s):  
Lena Maria Nilsson ◽  
Anna Winkvist ◽  
Ingegerd Johansson ◽  
Bernt Lindahl ◽  
Göran Hallmans ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Incident Cancer ◽  
Low Carbohydrate ◽  
Diet Score

scholarly journals Impact of Hyponatremia after Renal Transplantation on Decline of Renal Function, Graft Loss and Patient Survival: A Prospective Cohort Study

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2995
Author(s):  
Lena Berchtold ◽  
Anja Filzer ◽  
Rita Achermann ◽  
Vasileios Devetzis ◽  
Suzan Dahdal ◽  
...  
Keyword(s):  
Renal Function ◽  
Cohort Study ◽  
Renal Transplant ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Graft Loss ◽  
Secondary Outcome ◽  
Rapid Decline ◽  
Renal Transplant Recipients ◽  
Electrolyte Disorders

Background: Hyponatremia is one of the most common electrolyte disorders observed in hospitalized and ambulatory patients. Hyponatremia is associated with increased falls, fractures, prolonged hospitalisation and mortality. The clinical importance of hyponatremia in the renal transplant field is not well established, so the aim of this study was to determine the relationships between hyponatremia and mortality as main outcome and renal function decline and graft loss as secondary outcome among a prospective cohort of renal transplant recipients. Methods: This prospective cohort study included 1315 patients between 1 May 2008 and 31 December 2014. Hyponatremia was defined as sodium concentration below 136 mmol/L at 6 months after transplantation. The main endpoint was mortality. A secondary composite endpoint was also defined as: rapid decline in renal function (≥5 mL/min/1.73 m2 drop of the eGFR/year), graft loss or mortality. Results: Mean sodium was 140 ± 3.08 mmol/L. 97 patients displayed hyponatremia with a mean of 132.9 ± 3.05 mmol/L. Hyponatremia at 6 months after transplantation was associated neither with mortality (HR: 1.02; p = 0.97, 95% CI: 0.47–2.19), nor with the composite outcome defined as rapid decline in renal function, graft loss or mortality (logrank test p = 0.9). Conclusions: Hyponatremia 6 months after transplantation is not associated with mortality in kidney allograft patients.

scholarly journals Snoring and incident chronic kidney disease: a community-based prospective cohort study

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e030671 ◽  
Author(s):  
Changhyun Lee ◽  
Young Su Joo ◽  
Sangmi Lee ◽  
Shinchan Kang ◽  
Joohwan Kim ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Cohort Study ◽  
Kidney Disease ◽  
Prospective Cohort Study ◽  
Normal Renal Function ◽  
Prospective Cohort ◽  
Community Based ◽  
Incident Chronic Kidney Disease

ObjectivesPrevious studies have shown that symptoms of sleep-disordered breathing are associated with metabolic derangements and vascular disease development. However, the relationship between snoring and renal function is not well investigated. The association between snoring and the development of incident chronic kidney disease (CKD) in subjects with normal renal function was evaluated.DesignProspective cohort study.SettingAnsung (rural community) and Ansan (urban community) cities.ParticipantsCommunity-based cohort participants aged 40–69 years.MethodsA total of 9062 participants in the Ansung–Ansan cohort study were prospectively followed up from 2001 to 2014. The participants were classified into three groups: non-snorer, <1 day/week and ≥1 day/week. The main outcome was incident CKD, which was defined as an estimated glomerular filtration rate of <60 mL/min/1.73 m2during the follow-up period.Primary outcomeIncident CKD.ResultsThe mean subject age was 52.0±8.9 years, and 4372 (48.2%) subjects were male. The non-snorer,<1 day/week and ≥1 day/week groups included 3493 (38.5%), 3749 (41.4%), and 1820 (20.1%) subjects, respectively. Metabolic syndrome was more prevalent in the snoring groups than in the non-snoring group. Snoring frequency showed a significant positive relationship with age, waist:hip ratio, fasting glucose, total cholesterol (Tchol) and low-density lipoprotein cholesterol. During a mean follow-up of 8.9 years, 764 (8.4%) subjects developed CKD. Cox proportional hazards model analysis revealed that the risk of CKD development was significantly higher in subjects who snored ≥1 day/week than in non-snorers, even after adjustments for confounding factors (HR 1.23, 95% CI 1.09 to 1.38, p<0.01).ConclusionSnoring may increase the risk of CKD development in subjects with normal renal function.

The clinical utility of accurate NAFLD ultrasound grading: Results from a community-based, prospective cohort study

2021 ◽  
Vol 136 ◽  
pp. 109516
Author(s):  
Madunil Anuk Niriella ◽  
Dileepa Senajith Ediriweera ◽  
Anuradhani Kasturiratne ◽  
Deepa Gunasekara ◽  
Shamila Thivanshi De Silva ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Clinical Utility ◽  
Community Based

scholarly journals Village-to-village screening for hepatitis B and C using quantitative HBsAg and anti-HCV testing with reflex HCV core antigen tests in the remote communities of a resource-rich setting: a population-based prospective cohort study

BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e046115
Author(s):  
Te-Sheng Chang ◽  
Kao-Chi Chang ◽  
Wei-Ming Chen ◽  
Nien-Tzu Hsu ◽  
Chih-Yi Lee ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hepatitis B ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Population Based ◽  
Core Antigen ◽  
Remote Communities ◽  
Community Based ◽  
Patient Allocation ◽  
Hcv Testing

ObjectivesCommunity-based screening for hepatitis B virus (HBV) and hepatitis C virus (HCV) is essential for hepatitis elimination. This study attempted to increase screening accessibility and efficacy by using alternative tools.DesignPopulation-based prospective cohort study.SettingHepatitis elimination program at Yunlin County, Taiwan.ParticipantsAll 4552 individuals participated in 60 screening sessions of a community-based HBV and HCV screening project in five rural townships with approximately 95 000 inhabitants in central-western Taiwan.InterventionsTo increase accessibility, 60 outreach screening sessions were conducted in 41 disseminative sites. Quantitative HBV surface antigen (qHBsAg) and anti-HCV testing with reflex HCV core antigen (HCV Ag) tests were employed as alternative screening tools.Main outcome measuresCalculate village-specific prevalence of HBsAg, anti-HCV and HCV Ag and establish patient allocation strategies according to levels of qHBsAg HCV Ag and alanine aminotransferase (ALT).ResultsOf 4552 participants, 553, 697 and 290 were positive for HBsAg, anti-HCV and HCV Ag, respectively; 75 of them had both HBsAg and anti-HCV positivity. The average (range) number of participants in each screening session was 98 (31–150). The prevalence rates (range) of HBsAg, anti-HCV and HCV Ag were 12.1% (4.3%–19.4%), 15.3% (2.6%–52.3%) and 6.4% (0%–30.2%), respectively. The HCV Ag positivity rate among anti-HCV-positive participants was 42% (0%–100%). Using cut-off values of >200 IU/mL for qHBsAg, >3 fmol/L for HCV Ag and >40 IU/mL for ALT as criteria for patient referral, we noted an 80.2% reduction in referral burden. Three villages had high anti-HCV prevalences of 52.3%, 53.8% and 63.4% with corresponding viraemic prevalences of 23.2%, 30.1% and 22% and thus constituted newly identified HCV-hyperendemic villages.ConclusionOutreach hepatitis screening increases accessibility for residents in rural communities. Screening HBV and HCV through qHBsAg and HCV Ag tests provides information concerning viral activities, which might be conducive to precise patient allocation in remote communities.

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