Gastric cancer (GC) is the fourth-most common cancer in the world, with an estimated
1.034 million new cases in 2015, and the third-highest cause of cancer deaths, estimated at 785,558, in
2014. Early diagnosis and treatment greatly affect the survival rate in patients with GC: the 5‐year
survival rate of early GC reaches 90%‐95%, while the mortality rate significantly increases if GC
develops to the late stage. Recently, studies for the role of RhoA in the diseases have become a hot
topic, especially in the development of tumors. A study found that RhoA can regulate actin polymerization,
cell adhesion, motor-myosin, cell transformation, and the ability to participate in the activities
of cell movement, proliferation, migration, which are closely related to the invasion and metastasis of
tumor cells. However, the specific role of RhoA in tumor cells remains to be studied. Therefore, our
current study aimed to briefly review the role of RhoA in GC, especially for its associated signaling
pathways involved in the GC progression.
Lysyl oxidase promotes liver metastasis of gastric cancer via facilitating the reciprocal interactions between tumor cells and cancer associated fibroblasts
