Human ESC-Based Model of H3.3G34R-Mutant High-Grade Glioma Reveals the Oncogenic Role Of Human-Specific NOTCH2NL Genes

2020 ◽  
Author(s):  
Kosuke Funato ◽  
Ryan C. Smith ◽  
Yuhki Saito ◽  
Viviane Tabar
Keyword(s):  
High Grade Glioma ◽  
High Grade ◽  
Human Specific

Role of Klotho Protein in Tumor Genesis, Cancer Progression, and Prognosis in Patients with High-Grade Glioma

2019 ◽  
Vol 130 ◽  
pp. e324-e332 ◽  
Author(s):  
Naama Peshes-Yeloz ◽  
Lior Ungar ◽  
Anton Wohl ◽  
Elad Jacoby ◽  
Tamar Fisher ◽  
...  
Keyword(s):  
Cancer Progression ◽  
High Grade Glioma ◽  
High Grade ◽  
Klotho Protein

scholarly journals Single-Cell Transcriptomic Analysis Revealed a Critical Role of SPP1/CD44-Mediated Crosstalk Between Macrophages and Cancer Cells in Glioma

2021 ◽  
Vol 9 ◽  
Author(s):  
Cong He ◽  
Luoyan Sheng ◽  
Deshen Pan ◽  
Shuai Jiang ◽  
Li Ding ◽  
...  
Keyword(s):  
Single Cell ◽  
Tumor Heterogeneity ◽  
Molecular Mechanisms ◽  
Critical Role ◽  
Cell Communication ◽  
High Grade Glioma ◽  
Sequencing Analysis ◽  
High Grade ◽  
Cellular Components

High-grade glioma is one of the most lethal human cancers characterized by extensive tumor heterogeneity. In order to identify cellular and molecular mechanisms that drive tumor heterogeneity of this lethal disease, we performed single-cell RNA sequencing analysis of one high-grade glioma. Accordingly, we analyzed the individual cellular components in the ecosystem of this tumor. We found that tumor-associated macrophages are predominant in the immune microenvironment. Furthermore, we identified five distinct subpopulations of tumor cells, including one cycling, two OPC/NPC-like and two MES-like cell subpopulations. Moreover, we revealed the evolutionary transition from the cycling to OPC/NPC-like and MES-like cells by trajectory analysis. Importantly, we found that SPP1/CD44 interaction plays a critical role in macrophage-mediated activation of MES-like cells by exploring the cell-cell communication among all cellular components in the tumor ecosystem. Finally, we showed that high expression levels of both SPP1 and CD44 correlate with an increased infiltration of macrophages and poor prognosis of glioma patients. Taken together, this study provided a single-cell atlas of one high-grade glioma and revealed a critical role of macrophage-mediated SPP1/CD44 signaling in glioma progression, indicating that the SPP1/CD44 axis is a potential target for glioma treatment.

Reoperation for Recurrent High-Grade Glioma

Neurosurgery ◽  
2014 ◽  
Vol 75 (5) ◽  
pp. 491-499 ◽  
Author(s):  
Shawn L. Hervey-Jumper ◽  
Mitchel S. Berger
Keyword(s):  
Patient Selection ◽  
Survival Benefit ◽  
Performance Status ◽  
High Grade Glioma ◽  
World Health ◽  
Time Interval ◽  
Extensive Literature ◽  
High Grade ◽  
Glioma Recurrence

Abstract Optimal treatment for recurrent high-grade glioma continues to evolve. Currently, however, there is no consensus in the literature on the role of reoperation in the management of these patients. In this analysis, we reviewed the literature to examine the role of reoperation in patients with World Health Organization grade III or IV recurrent gliomas, focusing on how reoperation affects outcome, perioperative complications, and quality of life. An extensive literature review was performed through the use of the PubMed and Ovid Medline databases for January 1980 through August 2013. A total 31 studies were included in the final analysis. Of the 31 studies with significant data from single or multiple institutions, 29 demonstrated a survival benefit or improved functional status after reoperation for recurrent high-grade glioma. Indications for reoperation included new focal neurological deficits, tumor mass effect, signs of elevated intracranial pressure, headaches, increased seizure frequency, and radiographic evidence of tumor progression. Age was not a contraindication to reoperation. Time interval of at least 6 months between operations and favorable performance status (Karnofsky Performance Status score ≥70) were important predictors of benefit from reoperation. Extent of resection at reoperation improved survival, even in patients with subtotal resection at initial operation. Careful patient selection such as avoiding those individuals with poor performance status and bevacizumab within 4 weeks of surgery is important. Although limited to retrospective analysis and patient selection bias, mounting evidence suggests a survival benefit in patients receiving a reoperation at the time of high-grade glioma recurrence.

Investigation on the role of integrated PET/MRI for target volume definition and radiotherapy planning in patients with high grade glioma

2014 ◽  
Vol 112 (3) ◽  
pp. 425-429 ◽  
Author(s):  
Pierina Navarria ◽  
Giacomo Reggiori ◽  
Federico Pessina ◽  
Anna Maria Ascolese ◽  
Stefano Tomatis ◽  
...  
Keyword(s):  
High Grade Glioma ◽  
Target Volume ◽  
Radiotherapy Planning ◽  
High Grade ◽  
Target Volume Definition

scholarly journals PCN22 META-ANALYSIS OF THE ROLE OF SURGERY IN EFFICACY FOR PATIENTS WITH RECURRENT HIGH GRADE GLIOMA

2020 ◽  
Vol 23 ◽  
pp. S26
Author(s):  
H. Gruber ◽  
T. Montellano ◽  
M. Ladha
Keyword(s):  
Meta Analysis ◽  
High Grade Glioma ◽  
High Grade

scholarly journals Suspicious for recurrent low and high grade glioma and indeterminate MRI: the role of 18F-DOPA PET/CT

2017 ◽  
Vol 28 ◽  
pp. vi76-vi77
Author(s):  
L. Cuppari ◽  
G. Lombardi ◽  
L. Evangelista ◽  
A. Pambuku ◽  
G. Saladini ◽  
...  
Keyword(s):  
High Grade Glioma ◽  
High Grade ◽  
Pet Ct

scholarly journals The prognostic role of intragenic copy number breakpoints and identification of novel fusion genes in paediatric high grade glioma

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Diana Carvalho ◽  
Alan Mackay ◽  
Lynn Bjerke ◽  
Richard G Grundy ◽  
Celeste Lopes ◽  
...  
Keyword(s):  
Copy Number ◽  
High Grade Glioma ◽  
High Grade ◽  
Fusion Genes ◽  
Prognostic Role
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