The traditional treatment and prophylaxis of congenital facial malformations in children takes into account the results of wellknown instrumental research methods such as photometric facial analysis, orthopantomography, lateral teleradiography of the head, diagnostic models of jaws. Modern removable and non-removable appliances (functional and mechanical) are used in the treatment. At the same time, the functional effect involves relieving the muscle tension in the maxillofacial region and neck using the techniques of myofascial, segment-reflex massage of the cervical-collar zone and the palate, reliesing the tongue-root tension. To assess the effectiveness of restoring the myodynamic balance of the muscles of maxillofacial area, it is necessary to develop modern diagnostic methods. Our clinical experience shows the possibility of determining microsensory changes in the parameters of the head and neck region using non-invasive nano-, micro- and fiber-optic diagnostic and rehabilitation technologies. The developed diagnostic methods are safe for the patient and allow obtaining reliable research results. An interdisciplinary approach will help to improve the rehabilitation of children with congenital facial malformations. Key words: cleft lip and palate, diagnosis, treatment, interdisciplinary approach, children
PIWI-interacting RNA sequencing profiles in maternal plasma-derived exosomes reveal novel non-invasive prenatal biomarkers for the early diagnosis of nonsyndromic cleft lip and palate