Aqueous Polyethylene Glycols as Green Reaction Media for the Nitration of Aromatic and Heterocyclic Compounds in Presence of Sodium Nitrite Under Transition Metal-Free and Mineral Acid-Free Conditions- A Kinetic Study

2021 ◽  
Author(s):  
Sudhakar Chary Voruvala ◽  
Srinivas Pasnoori ◽  
Krishnaiah Ganga ◽  
Chinna Rajanna Kamatala ◽  
Umesh Kumar Utkoor
Keyword(s):  
Transition Metal ◽  
Kinetic Study ◽  
Sodium Nitrite ◽  
Heterocyclic Compounds ◽  
Mineral Acid ◽  
Polyethylene Glycols ◽  
Metal Free ◽  
Reaction Media

Recent Advances in Transition Metal Free Synthetic Protocols for Quinoline Derivatives

2020 ◽  
Vol 24 (16) ◽  
pp. 1815-1852
Author(s):  
Rukhsana Tabassum ◽  
Muhammad Ashfaq ◽  
Hiroyuki Oku
Keyword(s):  
Transition Metal ◽  
Heterocyclic Compounds ◽  
Pharmaceutical Chemistry ◽  
Quinoline Derivatives ◽  
Metal Free ◽  
Substituted Quinolines ◽  
Privileged Scaffold ◽  
Synthetic Routes ◽  
Therapeutic Activities ◽  
Insight Into

The quinoline moiety is a privileged scaffold among heterocyclic compounds that is an important construction motif in the fields of pharmaceutical chemistry. Quinoline molecule possesses a variety of therapeutic activities like antiviral, antimalarial, antibacterial, antitumor, anticancer, antioxidant antihypertensive, antifungal, anthelmintic, cardiotonic, anticonvulsant and anti-inflammatory. This review provides an insight into recent development in transition metal free novel and modified conventional synthetic routes to yield a wide variety of substituted quinolines.

scholarly journals Recent Advances in Transition-Metal-Free Late-Stage C-H and N-H Arylation of Heteroarenes Using Diaryliodonium Salts

2021 ◽  
Vol 14 (7) ◽  
pp. 661
Author(s):  
Thierry Besson ◽  
Corinne Fruit
Keyword(s):  
Transition Metal ◽  
Late Stage ◽  
Heterocyclic Compounds ◽  
Environmentally Friendly ◽  
Direct Arylation ◽  
Stepping Stone ◽  
Metal Free ◽  
Bond Forming ◽  
Diaryliodonium Salts ◽  
Recent Advances

Transition-metal-free direct arylation of C-H or N-H bonds is one of the key emerging methodologies that is currently attracting tremendous attention. Diaryliodonium salts serve as a stepping stone on the way to alternative environmentally friendly and straightforward pathways for the construction of C-C and C-heteroatom bonds. In this review, we emphasize the recent synthetic advances of late-stage C(sp2)-N and C(sp2)-C(sp2) bond-forming reactions under metal-free conditions using diaryliodonium salts as arylating reagent and its applications to the synthesis of new arylated bioactive heterocyclic compounds.

A novel transition metal free [bis-(trifluoroacetoxy)iodo]benzene (PIFA) mediated oxidative ipso nitration of organoboronic acids

2015 ◽  
Vol 13 (17) ◽  
pp. 4828-4832 ◽  
Author(s):  
Nachiketa Chatterjee ◽  
Divya Bhatt ◽  
Avijit Goswami
Keyword(s):  
Transition Metal ◽  
Sodium Nitrite ◽  
Metal Free ◽  
Organoboronic Acids

A mild, convenient and transition metal free methodology for oxidative ipso nitration of organoboronic acids, including heteroaryl- and alkylboronic acids, has been developed using a combination of [bis-(trifluoroacetoxy)]iodobenzene (PIFA) – N-bromosuccinimide (NBS) and sodium nitrite as the nitro source.

Transition-metal-free catalytic hydroboration reduction of amides to amines

2020 ◽  
Vol 7 (21) ◽  
pp. 3515-3520
Author(s):  
Wubing Yao ◽  
Jiali Wang ◽  
Aiguo Zhong ◽  
Shiliang Wang ◽  
Yinlin Shao
Keyword(s):  
Transition Metal ◽  
Selective Catalytic Reduction ◽  
Catalytic Reduction ◽  
Value Added ◽  
Metal Free

The selective catalytic reduction of amides to value-added amine products is a desirable but challenging transformation.

Deaminative carbonylative thioesterification of activated alkylamines with thiophenols under transition-metal-free conditions

2021 ◽  
Author(s):  
Fengqian Zhao ◽  
Xiao-Feng Wu
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Metal Free

A transition-metal-free radical carbonylation of activated alkylamines with thiophenols has been successfully developed. Various thioesters were selectively produced with moderate to good yields.

Regioselective C3-H Trifluoromethylation of 2H-Indazole Under Transition-Metal-Free Photoredox Catalysis

2019 ◽  
Author(s):  
Arumugavel Murugan ◽  
Venkata Nagarjuna Babu ◽  
Nagaraj Sabarinathan ◽  
Sharada Duddu. S
Keyword(s):  
Transition Metal ◽  
Visible Light ◽  
Practical Approach ◽  
Hypervalent Iodine ◽  
Radical Mechanism ◽  
Photoredox Catalysis ◽  
Metal Free

Here we report a visible-light-promoted metal-free regioselective C3-H trifluoromehtylation reaction that proceeds via radical mechanism and which supported by control experiments. The combination of photoredox catalysis and hypervalent iodine reagent provides a practical approach for the present trifluoromethylation reaction and synthesis of a library of trifluoromethylated indazoles.

Selective Oxidation of Alcohols Catalyzed by a Transition Metal-Free System of NHPI/DDQ/NaNO2

2011 ◽  
Vol 32 (1) ◽  
pp. 118-122 ◽  
Author(s):  
Lipeng ZHOU ◽  
Chaofeng ZHANG ◽  
Tao FANG ◽  
Bingbing ZHANG ◽  
Ying WANG ◽  
...  
Keyword(s):  
Transition Metal ◽  
Selective Oxidation ◽  
Free System ◽  
Metal Free ◽  
Oxidation Of Alcohols

Synthesis of Pyrrolo[1,2-a][1,6]- and [1,8]naphthyridines by Alkyne-Carbonyl Metathesis

Synthesis ◽  
2020 ◽  
Author(s):  
Peter Ehlers ◽  
Peter Langer ◽  
Marian Blanco Ponce ◽  
Silvio Parpart ◽  
Alexander Villinger ◽  
...  
Keyword(s):  
Heterocyclic Compounds ◽  
Metathesis Reaction ◽  
Synthetic Methodology ◽  
Facile Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
Metal Free ◽  
Modular Synthesis

AbstractA concise and modular synthesis of pyrrolo[1,2-a][1,6]- and [1,8]naphthyridines by a one-pot two-step reaction consisting of electrophilic acylation followed by an alkyne-carbonyl-metathesis reaction as the final cyclization step is reported. This developed synthetic methodology allows the facile synthesis of these heterocyclic core structures in mainly high overall yields under metal-free conditions. Reaction conditions are carefully optimized and display a novel supplement to access these tricyclic heterocyclic compounds.

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