Screening of Anti-Atrophic Peptides by Using Photo-Cleavable Peptide Array and 96-Well Scale Contractile Human Skeletal Muscle Atrophy Models

2022 ◽  
Author(s):  
Kazuki Yamamoto ◽  
Saki Ohsumi ◽  
Takunori Nagashima ◽  
Hirokazu Akiyama ◽  
Hiroyuki Honda ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Atrophy ◽  
Human Skeletal Muscle ◽  
Skeletal Muscle Atrophy ◽  
Peptide Array ◽  
Cleavable Peptide

scholarly journals Protein translation, proteolysis and autophagy in human skeletal muscle atrophy after spinal cord injury

2018 ◽  
Vol 223 (3) ◽  
pp. e13051 ◽  
Author(s):  
L. S. Lundell ◽  
M. Savikj ◽  
E. Kostovski ◽  
P. O. Iversen ◽  
J. R. Zierath ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Muscle Atrophy ◽  
Human Skeletal Muscle ◽  
Protein Translation ◽  
Skeletal Muscle Atrophy ◽  
Cord Injury

Ubiquitin ligases MuRF1 and MAFbx in human skeletal muscle atrophy

2008 ◽  
Vol 75 (1) ◽  
pp. 53-57 ◽  
Author(s):  
Luigi de Palma ◽  
Mario Marinelli ◽  
Matteo Pavan ◽  
Alessandro Orazi
Keyword(s):  
Skeletal Muscle ◽  
Muscle Atrophy ◽  
Human Skeletal Muscle ◽  
Ubiquitin Ligases ◽  
Skeletal Muscle Atrophy

scholarly journals mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Steven D Kunkel ◽  
Manish Suneja ◽  
Scott M Ebert ◽  
Kale S Bongers ◽  
Daniel K Fox ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mrna Expression ◽  
Muscle Mass ◽  
Muscle Atrophy ◽  
Natural Compound ◽  
Human Skeletal Muscle ◽  
Skeletal Muscle Atrophy

scholarly journals mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass

2011 ◽  
Vol 13 (6) ◽  
pp. 627-638 ◽  
Author(s):  
Steven D. Kunkel ◽  
Manish Suneja ◽  
Scott M. Ebert ◽  
Kale S. Bongers ◽  
Daniel K. Fox ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mrna Expression ◽  
Muscle Mass ◽  
Muscle Atrophy ◽  
Natural Compound ◽  
Human Skeletal Muscle ◽  
Skeletal Muscle Atrophy

scholarly journals A mini review: Proteomics approaches to understand disused vs. exercised human skeletal muscle

2018 ◽  
Vol 50 (9) ◽  
pp. 746-757 ◽  
Author(s):  
Yoshitake Cho ◽  
Robert S. Ross
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Muscle Atrophy ◽  
Human Skeletal Muscle ◽  
Molecular Mechanisms ◽  
Bed Rest ◽  
Skeletal Muscle Atrophy ◽  
Direct Result ◽  
Muscle Disorders ◽  
Exercise Induced

Immobilization, bed rest, or denervation leads to muscle disuse and subsequent skeletal muscle atrophy. Muscle atrophy can also occur as a component of various chronic diseases such as cancer, AIDS, sepsis, diabetes, and chronic heart failure or as a direct result of genetic muscle disorders. In addition to this atrophic loss of muscle mass, metabolic deregulation of muscle also occurs. In contrast, physical exercise plays a beneficial role in counteracting disuse-induced atrophy by increasing muscle mass and strength. Along with this, exercise can also reduce mitochondrial dysfunction and metabolic deregulation. Still, while exercise causes valuable metabolic and functional adaptations in skeletal muscle, the mechanisms and effectors that lead to these changes such as increased mitochondria content or enhanced protein synthesis are not fully understood. Therefore, mechanistic insights may ultimately provide novel ways to treat disuse induced atrophy and metabolic deregulation. Mass spectrometry (MS)-based proteomics offers enormous promise for investigating the molecular mechanisms underlying disuse and exercise-induced changes in skeletal muscle. This review will focus on initial findings uncovered by using proteomics approaches with human skeletal muscle specimens and discuss their potential for the future study.

Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in Akt and an increase in atrogin‐1

2006 ◽  
Vol 20 (3) ◽  
pp. 583-585 ◽  
Author(s):  
Bertrand Léger ◽  
Lodovica Vergani ◽  
Gianni Sorarù ◽  
Peter Hespel ◽  
Wim Derave ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Amyotrophic Lateral Sclerosis ◽  
Muscle Atrophy ◽  
Human Skeletal Muscle ◽  
Skeletal Muscle Atrophy ◽  
Lateral Sclerosis

1137-P: Anti–Skeletal Muscle Atrophy Effect of Luseogliflozin via Lipidome Modification in db/db Mice

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1137-P
Author(s):  
RYP BAMBA
Keyword(s):  
Skeletal Muscle ◽  
Muscle Atrophy ◽  
Skeletal Muscle Atrophy
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