scholarly journals Genomic and TCR Repertoire Intratumor Heterogeneity of Small-cell Lung Cancer and its Impact on Survival

immuneACCESS ◽  
2021 ◽  
Author(s):  
M Chen ◽  
R Chen ◽  
Y Jin ◽  
J Li ◽  
J Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Intratumor Heterogeneity ◽  
Small Cell Lung ◽  
Tcr Repertoire ◽  
Impact On Survival

scholarly journals Genomic and TCR Repertoire Intratumor Heterogeneity of Small-cell Lung Cancer and its Impact on Survival

2020 ◽  
Author(s):  
Ming Chen ◽  
Runzhe Chen ◽  
Ying Jin ◽  
Jun Li ◽  
Jiexin Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Cell Receptor ◽  
Small Cell ◽  
Intratumor Heterogeneity ◽  
High Recurrence Rate ◽  
Small Cell Lung ◽  
Lung Cancers ◽  
Tcr Repertoire

AbstractSmall-cell lung cancer (SCLC) is speculated to harbor complex genomic intratumor heterogeneity (ITH) associated with high recurrence rate and suboptimal response to immunotherapy. Here, we revealed a rather homogeneous mutational landscape but extremely suppressed and heterogeneous T cell receptor (TCR) repertoire in SCLCs. Higher mutational burden, lower chromosomal copy number aberration (CNA) burden, less CNA ITH and less TCR ITH were associated with longer overall survival of SCLC patients. Compared to non-small cell lung cancers (NSCLCs), SCLCs had similar predicted neoantigen burden and mutational ITH, but significantly more suppressed and heterogeneous TCR repertoire that may be associated with higher CNA burden and CNA ITH in SCLC. Novel therapeutic strategies targeting CNA could potentially improve the tumor immune microenvironment and response to immunotherapy in SCLC.

scholarly journals Genomic and TCR Repertoire Intratumor Heterogeneity of Small-cell Lung Cancer and its Impact on Survival

2021 ◽  
Author(s):  
Ming Chen ◽  
Runzhe Chen ◽  
Ying Jin ◽  
Jun Li ◽  
Jiexin Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
T Cell ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Cell Receptor ◽  
Small Cell ◽  
Intratumor Heterogeneity ◽  
High Recurrence Rate ◽  
Small Cell Lung ◽  
Tcr Repertoire

Abstract Small-cell lung cancer (SCLC) is speculated to harbor complex genomic intratumor heterogeneity (ITH) associated with high recurrence rate and suboptimal response to immunotherapy. Here, using multi-region whole exome/T cell receptor (TCR) sequencing as well as immunohistochemistry (IHC), we revealed a rather homogeneous mutational landscape but extremely cold and heterogeneous TCR repertoire in limited-stage SCLC (LS-SCLC) tumors. Compared to localized non-small cell lung cancers (NSCLCs), LS-SCLCs had similar predicted neoantigen burden and genomic ITH, but significantly colder and more heterogeneous TCR repertoire associated with higher chromosomal copy number aberration (CNA) burden. Higher mutational burden, higher T cell infiltration and positive PD-L1 expression were associated with longer overall survival (OS), while higher CNA burden were associated with shorter OS in patients with LS-SCLC.

scholarly journals Leptomeningeal Carcinomatosis in Non–Small-Cell Lung Cancer Patients: Impact on Survival and Correlated Prognostic Factors

2013 ◽  
Vol 8 (2) ◽  
pp. 185-191 ◽  
Author(s):  
Su Jin Lee ◽  
Jung-Il Lee ◽  
Do-Hyun Nam ◽  
Young Chan Ahn ◽  
Jung Ho Han ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Prognostic Factors ◽  
Small Cell Lung Cancer ◽  
Cancer Patients ◽  
Cell Lung Cancer ◽  
Leptomeningeal Carcinomatosis ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Patients ◽  
Impact On Survival

scholarly journals New N1/N2 classification and lobe specific lymphatic drainage: Impact on survival in patients with non-small cell lung cancer treated with surgery

Lung Cancer ◽  
2021 ◽  
Vol 151 ◽  
pp. 84-90
Author(s):  
Thomas Tsitsias ◽  
Lawrence Okiror ◽  
Lukacs Veres ◽  
Juliet King ◽  
Karen Harrison-Phipps ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Lymphatic Drainage ◽  
Small Cell ◽  
Small Cell Lung ◽  
Impact On Survival

scholarly journals Association between serum HGF levels and neutrophil counts in small cell lung cancer and their impact on survival

2019 ◽  
Vol 30 ◽  
pp. v714
Author(s):  
L. Moliner ◽  
M. Hardy-Werbin ◽  
X. Duran ◽  
O. Arpí ◽  
Á Taus ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Impact On Survival

scholarly journals OA15.04 Genomic and TCR Intratumor Heterogeneity of Small-Cell Lung Cancer by Multiregion Sequencing: An Association with Survival

2019 ◽  
Vol 14 (10) ◽  
pp. S246-S247
Author(s):  
R. Chen ◽  
Y. Jin ◽  
J. Li ◽  
J. Zhang ◽  
J. Fujimoto ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Intratumor Heterogeneity ◽  
Small Cell Lung

scholarly journals Utilization of Hyperfractionated Radiation in Small-Cell Lung Cancer and Its Impact on Survival

2015 ◽  
Vol 10 (12) ◽  
pp. 1770-1775 ◽  
Author(s):  
David Schreiber ◽  
Andrew T. Wong ◽  
David Schwartz ◽  
Justin Rineer
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Impact On Survival

Pre-operative serum levels of angiogenic tumour markers in non-small cell lung cancer and its impact on survival

1999 ◽  
Vol 35 ◽  
pp. S250
Author(s):  
D. Brattström ◽  
M. Bergqvist ◽  
P. Hesselius ◽  
A. Larsson ◽  
K. Lamberg ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Serum Levels ◽  
Small Cell ◽  
Tumour Markers ◽  
Small Cell Lung ◽  
Impact On Survival

A novel noninvasive biomarker based on peripheral PD-1posi CD8 T-cell receptor repertoire correlated with clinical outcomes to immunotherapy in non-small cell lung cancer.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e14174-e14174
Author(s):  
Jie-Fei Han ◽  
Zhijie Wang ◽  
Hua Bai ◽  
Si Chen ◽  
Yuqi Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Clinical Outcomes ◽  
Cell Lung Cancer ◽  
Cell Receptor ◽  
Small Cell ◽  
Small Cell Lung ◽  
Non Invasive ◽  
Tcr Repertoire ◽  
Tcr Diversity

e14174 Background: Although advances on exploration of biomarkers personalized the immune checkpoint blockades (ICBs) delivery, non-invasive blood-based approach remainsan intriguing area for further investigation.This study investigated the feasibility of peripheral isolated PD-1posiCD8T cell receptor (TCR) repertoire profiling in predicting the clinical outcomes of ICBs treatment for non-small cell lung cancer (NSCLC) patients. Methods: The study comprised two independent cohorts (A and B), ultimately recruiting total 40 from 51 patients with stage IIIB-IV NSCLCs who received anti-PD-1/PD-L1 therapy between March 14, 2017 and May 2, 2018. Peripheral blood samples of pre- and post-ICBs (the timepoint of first imaging evaluation) were prospectively collected, and PD-1posiCD8 T cells were isolated by flow cytometry for TCR sequencing. The diversity and clonality of the TCR repertoire were calculated for biomarker profiling. Cohort A (n = 25) was used as a training set for discovery of TCR diversity in the prediction of response to ICBs, and cohort B (n = 15) as a validation set. Progression-free survival (PFS) and response to ICBs treatment were correlated with TCR diversity and clonality. Results: In cohort A, patients with high pre-ICBs PD-1posiCD8 TCR diversity had longer PFS than those with low diversity (6.5 vs. 2.6 months, p = .045), which were substantially validated in cohort B. By using the incorporated set, pre-ICBs PD-1posiCD8 TCR diversity exhibited an optimal Youden's index of 0.81 with a sensitivity of 0.87 and a specificity of 0.94 in clarifying clinical response of ICBs (PR+SD vs. PD). Patients with increased PD-1posiCD8 TCR clonality demonstrated significantly improved PFS (7.3 vs. 2.7 months, p = .005) compared to those with decreased TCR clonality. Interestingly, two patients with initial pseudo-PD exhibited similar change of TCR clonality and expansion of dominant TCR clones with those with PR, but not PD. Conclusions: Peripheral PD-1posiCD8 TCR repertoire sequencing might be a promising non-invasive approach for selecting patients who could benefit from ICBs treatment, which guaranteed the further investigation and validation by larger cohorts.

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