scholarly journals Multikinase inhibitors in the treatment of thyroid cancer: specific role of lenvatinib

2014 ◽  
pp. 129 ◽  
Author(s):  
Jaume Capdevila ◽  
Neda Stjepanovic

2014 ◽  
Vol 10 (14) ◽  
pp. 2099-2102 ◽  
Author(s):  
Alberto Mangano ◽  
Hoon Yub Kim ◽  
Georgios D Lianos ◽  
Dimitrios H Roukos ◽  
Gianlorenzo Dionigi


2020 ◽  
pp. 301-310
Author(s):  
K.A. GARIPOV ◽  
◽  
Z.A. AFANASIEVA ◽  
A.D. GAFIULLINA ◽  
◽  
...  

According to studies, 25-66% of patients with metastatic highly differentiated thyroid cancer (DTC) develop partial or complete resistance of metastases to therapy with radioactive iodine. The review discusses the molecular mechanisms for the involvement of various apoptosis proteins in the formation of radioiodine resistance in patients with DTC, as well as the molecular mechanisms of the action of multikinase inhibitors, with a range of therapeutic effects from complete tumour regression to stabilization, on apoptosis. Considering the literature on the ambiguous role of apoptosis in the formation of radioiodine resistance in DTC, required further examination of its molecular mechanisms, its relationship with such a process as autophagy, the effect of multikinase inhibitors on its molecular basis and on overcoming iodine resistance. Studying the mechanism of apoptosis regulations gives a chance to find new targeted aims exposure in its individual stages in order to regulate or correct them.



2016 ◽  
Vol 22 (39) ◽  
pp. 5915-5926 ◽  
Author(s):  
Rasmus Laursen ◽  
Markus Wehland ◽  
Sascha Kopp ◽  
Jessica Pietsch ◽  
Manfred Infanger ◽  
...  






Author(s):  
Robert Pfaller

Starting from a passage from Slavoj Žižek`s brilliant book The Sublime Object of Ideology, the very passage on canned laughter that gave such precious support for the development of the theory of interpassivity, this chapter examines a question that has proved indispensable for the study of interpassivity: namely, what does it mean for a theory to proceed by examples? What is the specific role of the example in certain example-friendly theories, for example in Žižek’s philosophy?



2013 ◽  
Author(s):  
Emese Mezosi ◽  
Laszlo Bajnok ◽  
Karoly Rucz ◽  
Csaba Weninger ◽  
Erzsebet Schmidt ◽  
...  


Author(s):  
Blertina Dyrmishi ◽  
Taulant Olldashi ◽  
Ema Lumi ◽  
Entela Puca ◽  
Dorina Ylli ◽  
...  




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