scholarly journals Stem cell therapies for age-related macular degeneration: the past, present, and future

2015 ◽  
pp. 255 ◽  
Author(s):  
Yalong Dang ◽  
Chun Zhang ◽  
Yu Zhu
Keyword(s):  
Stem Cell ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
The Past ◽  
Age Related

scholarly journals Trends of Stem Cell Therapies in Age-Related Macular Degeneration

2021 ◽  
Vol 10 (8) ◽  
pp. 1785
Author(s):  
Tadao Maeda ◽  
Sunao Sugita ◽  
Yasuo Kurimoto ◽  
Masayo Takahashi
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Macular Degeneration ◽  
Cell Transplantation ◽  
New Technologies ◽  
Retinal Pigment ◽  
Age Related Macular Degeneration ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Age Related

Age-related macular degeneration (AMD) is a highly prevalent irreversible impairment in the elderly population worldwide. Stem cell therapies have been considered potentially viable for treating AMD through the direct replacement of degenerated cells or secretion of trophic factors that facilitate the survival of existing cells. Among them, the safety of pluripotent stem cell-derived retinal pigment epithelial (RPE) cell transplantation against AMD, and some hereditary retinal degenerative diseases, has been discussed to a certain extent in clinical studies of RPE cell transplantation. Preparations are in progress for its clinical application. On the other hand, clinical trials using somatic stem cells are also being conducted, though these had controversial outcomes. Retinal regenerative medicine using stem cells is expected to make steady progress toward practical use while new technologies are incorporated from various fields, thereby making the role of ophthalmologists in this field increasingly important.

Development of human embryonic stem cell therapies for age-related macular degeneration

2013 ◽  
Vol 36 (7) ◽  
pp. 385-395 ◽  
Author(s):  
Amanda-Jayne F. Carr ◽  
Matthew J.K. Smart ◽  
Conor M. Ramsden ◽  
Michael B. Powner ◽  
Lyndon da Cruz ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Macular Degeneration ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Age Related Macular Degeneration ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Age Related

Stem Cell Therapies for Blindness due to Corneal, Lens, and Retinal Diseases: A Review

2019 ◽  
Author(s):  
Vincent Gallicchio
Keyword(s):  
Stem Cell ◽  
Age Related Macular Degeneration ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Standard Clinical Practice ◽  
Age Related ◽  
Wide Range ◽  
Corneal Lens ◽  
Cell Sources ◽  
Disease Pathways

Stem cell therapies are continuing to be researched and implemented to treat a wide range of disorders that result in blindness. Major structures of the eye most prevalently tied to blindness are the cornea, lens, and retina, and specific conditions resulting in blindness includes corneal disease, stromal scarring, cataracts, age-related macular degeneration, retinitis pigmentosa, glaucoma, and diabetic retinopathy. This review covers a detailed description of the structures of the eye, the causes and corresponding disease pathways of each form of corneal, lens, and retinal dysfunction that results in blindness, and the current stem cell sources being researched and implemented, through animal models and clinical trials, to treat blindness. The review evaluates the progress of stem cell research and trials and presents the obstacles that remain to be overcome before stem cell sources to treat blindness can become standard clinical practice.

Human Pluripotent Stem Cell Strategies for Age-Related Macular Degeneration

2014 ◽  
Vol 91 (8) ◽  
pp. 887-893 ◽  
Author(s):  
Kathryn C. Davidson ◽  
Robyn H. Guymer ◽  
Martin F. Pera ◽  
Alice Pébay
Keyword(s):  
Stem Cell ◽  
Macular Degeneration ◽  
Pluripotent Stem Cell ◽  
Age Related Macular Degeneration ◽  
Human Pluripotent Stem Cell ◽  
Age Related

Stem Cell Therapy for the Treatment of Dry Age-Related Macular Degeneration

2015 ◽  
Vol 3 (1) ◽  
pp. 16-25
Author(s):  
Lisa C. Olmos ◽  
Hossein Nazari ◽  
Damien C. Rodger ◽  
Mark S. Humayun
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Macular Degeneration ◽  
Stem Cell Therapy ◽  
Age Related Macular Degeneration ◽  
Age Related

Multimodal Physiological Medicine and Macular Degeneration

2010 ◽  
Vol 04 (01) ◽  
pp. 101
Author(s):  
George W Rozakis ◽  
Sergey A Dzugan ◽  
◽  
Keyword(s):  
Stem Cell ◽  
Macular Degeneration ◽  
Retinal Pigment Epithelial ◽  
Cell Function ◽  
Retinal Pigment Epithelial Cell ◽  
Retinal Pigment ◽  
Age Related Macular Degeneration ◽  
Pigment Epithelial ◽  
Age Related ◽  
Steroidal Hormones

Multimodal physiological medicine is the art of restoring physiology to youthful levels for the purpose of preventing and treating age-related diseases. Age-related macular degeneration (AMD) is presented as a disease that is caused by multiple errors of physiology including deficiencies of the steroidal hormones dehydroepiandrosterone (DHEA), pregnenolone, oestriol, oestradiol, oestrone, testosterone and progesterone as well as deficiencies in melatonin, zinc and other nutrients. It is proposed that multiple steroidal deficiency results in a compensatory attempt to synthesise hormones from cholesterol in the macula and that this conversion is dysfunctional in AMD, resulting in cholesterol-laden drusen. Furthermore, it is suggested that physiological errors indirectly lead to retinal pigment epithelial cell failure due to a decline in stem cell function. It is suggested that macular degeneration can be safely and more efficaciously treated with combinations of hormones, nutrients and vitamins and that such treatment strikes at the underlying cause(s) of the disease and may reduce associated cardiovascular risk.

Tractional Maculopathies in Age-related Macular Degeneration

2012 ◽  
Vol 05 (02) ◽  
pp. 119 ◽  
Author(s):  
Cynthia X Qian ◽  
William J Foster ◽  
Flavio A Rezende ◽  
◽  
◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
The Elderly ◽  
Developed Countries ◽  
Age Related Macular Degeneration ◽  
The Past ◽  
Age Related ◽  
Surgical Options ◽  
Made In

Age-related macular degeneration (AMD) is the leading cause of blindness among the elderly in developed countries. Much progress has been and continues to be made in search of better visual outcomes for dry and exudative AMD. Over the past decade, the importance of vitreomacular attachments has been recognized in AMD. In this article, we better characterize and describe vitreomacular and photoreceptor-retinal pigment epithelium interface relationships in AMD among treated and untreated patients and describe the surgical options available as well as their outcomes and possible complications.

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