Safety Study of AAV hTert and Klotho Gene Transfer Therapy for Dementia

A sponsored, interventional, non-randomized study without a control group using a novel and proprietary central nervous system gene transfer method to deliver AAV hTert and Klotho genes to five patients with mild or moderate dementia was performed to primarily evaluate safety. Clinical response data was gathered as a secondary interest. The therapy demonstrated a very high safety profile with no serious adverse effects identified. Clinical evaluation of the patients over the course of the one year follow up yielded significant findings with all five patients demonstrating evident reversal of Dementia symptoms such as sustained cognitive improvement as measured by the Folstein exam. Telomere analysis was performed before and after the therapy. A measurable elongation of the participants telomeres was identified, and biological age was reduced as chronological age increased.

Preliminary Results of Vitamin D3 Application Combined With Anisodamine In the Treatment of Alopecia Areata in Children

Alopecia areata is a form of inflammatory hair loss that has been known for a long time, but its cause is largely unexplored. It is characterized by the patient's hair falling out in a circular pattern, which is why this disease is also called circular hair loss. This occurs in 80% of cases in the head area but can also affect the beard in men and in exceptional cases the entire body hair.

Alice in Wonderland Syndrome: Is There a Genetic Origin?

We describe the case of a familial situation of Alice in Wonderland seizures in a 39 years-old mother and a 14-year-old son from Southampton, United Kingdom.To date, there are only few reports supporting the thesis, Alice in Wonderland Syndrome could be hereditary. Next-generation sequencing could help to clear the genetics in AIWS.

First-Person Perspective of Alice in Wonderland Like Visual Perceptions Presented Primary as Microsomatognosia as Leading Symptom of a 24 Years-Old Student From Chile

AIWS is a disorientating form of seizures that affect in peculiar visual perception. AIWS is a neurological form of seizures that can affect the brain, especially the temporoparietal junction and visual pathways leading to impaired and bizarre visual perceptions. The origin of AIWS is yet not known exactly. Cases of migraines, brain tumors, depression episodes, epilepsy, delirium, psychotropic drugs, ischemic stroke, EBV, mycoplasma and malaria infections correlate like seizures with AIWS are published before.

Preliminary Results of a Telemedicine Questionnaire in Pediatrics as an Innovative New Tool to Diagnose and Treat Children Virtually in an Ambulatory Setting: Analysis of 400 Pediatric Consultations

Virtual online consultation enables real-time exchange between two or more participants at different locations via audio and video communication [1-9]. In the visualization of the discussion partners, telemedicine thus differs from a classic telephone conference and expands it to include the visual component [1-6].

Homologous Use of Umbilical Cord Tissue for Knee Pain

Context: Injection with homologously-used umbilical cord tissue allograft has not been adequately studied in patients suffering from knee pain. Objectives: The goal of this study is to determine if knee pain subjects who received cryopreserved umbilical cord tissue (UCT) injected into knee joints experience less knee pain, better function, decreased physical limitations, and reduction of medications (e.g., opiates, NSAIDs, and acetaminophen) over a 6-month period. Methods: Prior to initiation of this study, Institutional Review Board (IRB) approval was obtained. Visual Analog Scale (VAS), Western Ontario and McMaster Universities Osteoarthritic Index (WOMAC), and medication usage data were recorded for thirty (30) consenting knee pain subjects receiving UCT at a single site in the United States. Subject profile information was also gathered and utilized to gain further insight into any effects of age, gender, and BMI on pain improvement over time. Results: Mean resting VAS scores improved from 1.95 to 0.83 over 6 months (p<0.001), while mean VAS scores with activity improved from 6.28 to 2.87 (p<0.001) for the same period. There was no strong evidence of correlation found between gender and VAS scores (resting or with activity). However, there were statistically significant correlations found for both BMI vs. Pre-injection VAS with activity scores (r=0.402, p=.028) and Age vs. Pre-injection VAS with activity scores (r=0.434, p=.017). Mean WOMAC daily activity function scores improved from 44.7 to 18.5 over the same 6 months (p<.001). Overall, of the patients who used medications at the beginning of the study (18), 77.8% of them reduced or eliminated medication use. Conclusion: Analysis demonstrates that injection with UCT decreases pain, improves physical function, and allows for less medication use for at least 6 months.

Neurogenesis-An Overview

Neurogenesis is a phenomenon that involves the formation of new neurons in the brain by neural stem cells (NSCs). Investigators have confirmed that neurogenesis occurs in discrete parts of the adult brain as opposed to the embryos [1]. However, this was not the case long time back. Researchers have always been interested in learning if humans or other large organisms could show regenerative properties like the one seen in specific small organisms which can regrow different parts of their own bodies [2]. If possible, this would lead to a new avenue in therapeutics as more scientists would try to stimulate regeneration to deal with injury or any harmful stimuli. Like mentioned previously, researchers were not convinced with this approach and deemed that there is no possibility of adult neurogenesis [3].

Therapy on Parkinson’s Disease

Parkinson's disorder (PD) is a central nervous condition that causes tremors and affects mobility. Symptoms appear slowly, generally beginning with a slight shaking in one hand. Tremors are typical, but the disease can also cause stiffness or sluggish movement. Dopaminergic levels drop when nerve cells in the brain are damaged, leading to Parkinson's disease. The condition can start with tremors and progress to additional symptoms such as sluggish movements, stiffness, and a loss of balance. Therapy can help reduce the symptoms of Parkinson's disease, but it can't cure it. It is critical to obtain diagnostic testing by laboratory or imaging tests. A therapy expert can show how to make the proper motions to improve movement, flexibility, and balance while still allowing the patient to maintain personal independence. Exercising can help strengthen the muscles, improve flexibility and balance. Therapy can also boost mood and help the patient cope with sadness or anxiety.

Parkinson’s Disease-Overview

Parkinson’s disease one of the most complex neurological disorder. The disease risk and progression are due to common genetic variants. Approximately 6.2 million cases are reported each year according to the statistics published in 2015 whereas it is expected that this number will be twice by 2040. There are two types of Parkinson’s disease, familial Parkinson’s disease, and sporadic Parkinson’s disease. The disease is characterized by the presence of Lewy bodies. Adult age increases the risk of Parkinson’s disease. In this review, we provide an overview of the disease pathology of Lewy bodies in the occurrence of Parkinson’s disease, in vitro studies to determine the role of iPSCs in treatment of Parkinson’s disease, in vivo studies to determine the role of animal model in studying disease modeling, and future prospective how single-cell RNA sequencing technology is a major advancement in studying and find the treatment for Parkinson’s disease.

Preliminary Experience of Video Conferences in Pediatrics in Covid-19 Pandemic

A video conference enables real-time exchange between two or more participants at different locations via audio and video communication. In terms of the visualization of the discussion partners, a videoconference thus differs from a classic telephone conference and expands it to include the visual component. The term videoconferencing system refers to the technological setup or infrastructure behind such a videoconference, the videoconferencing technology. This refers to the hardware and software components that are required to carry out a videoconference technically.