scholarly journals Pre-Morbid Risk Factors for Amyotrophic Lateral Sclerosis: Prospective Cohort Study

2021 ◽  
Vol Volume 13 ◽  
pp. 941-947
Author(s):  
G David Batty ◽  
Catharine R Gale
Keyword(s):  
Risk Factors ◽  
Amyotrophic Lateral Sclerosis ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Lateral Sclerosis

scholarly journals Pre-morbid risk factors for amyotrophic lateral sclerosis: prospective cohort study

2021 ◽  
Author(s):  
George David Batty ◽  
Catharine Gale
Keyword(s):  
Risk Factors ◽  
Amyotrophic Lateral Sclerosis ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Potential Risk ◽  
Prospective Cohort ◽  
Reverse Causality ◽  
Risk Indices ◽  
Increased Risk ◽  
Lateral Sclerosis

Background: As a neurodegenerative disorder with high case-fatality, there is a need to identify primary, modifiable risk factors for amyotrophic lateral sclerosis (ALS). Their detection has, however, proved elusive and this may be ascribed to the scarcity of well-characterised, sufficiently-powered cohort studies necessary to explore the aetiology of this rare condition. Methods: UK Biobank is an on-going, closed, prospective cohort study in which 502,524 participants (273,420 women) have been linked to national hospital and mortality registries. Baseline data collection took place between 2006 and 2010 when a range of psychosocial, physiological, and demographic data were captured. Results: Approximately 11 years of event surveillance gave rise to 301 hospitalisations and 279 deaths ascribed to ALS. After left censoring to account for reverse causality and adjustment for confounding factors, being older (hazard ratio per 10 year increase; 95% confidence interval: 1.92; 1.58, 2.33) and male (1.37; 1.00, 1.87) were associated with elevated rates of hospitalisation for ALS. Similar effects were apparent when death due to the disorder was the outcome of interest. Of the remaining 23 potential risk indices, however, there was only a suggestion that taller people experienced an increased risk of hospitalisation (per SD increase: 1.31; 1.09, 1.59). Conclusions: In the present study, a comprehensive array of potential risk indices were essentially unrelated to later ALS.

scholarly journals Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study

2016 ◽  
Vol 31 (3) ◽  
pp. 255-266 ◽  
Author(s):  
Valentina Gallo ◽  
Nicola Vanacore ◽  
H. Bas Bueno-de-Mesquita ◽  
Roel Vermeulen ◽  
Carol Brayne ◽  
...  
Keyword(s):  
Physical Activity ◽  
Amyotrophic Lateral Sclerosis ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Lateral Sclerosis

Relationship between EMG-detected and ultrasound-detected fasciculations in amyotrophic lateral sclerosis: A prospective cohort study

2020 ◽  
Vol 131 (1) ◽  
pp. 259-264 ◽  
Author(s):  
Kota Bokuda ◽  
Toshio Shimizu ◽  
Hideki Kimura ◽  
Ryo Morishima ◽  
Tsutomu Kamiyama ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Lateral Sclerosis

Smoking, Snuff Dipping and the Risk of Amyotrophic Lateral Sclerosis – A Prospective Cohort Study

2006 ◽  
Vol 27 (4) ◽  
pp. 217-221 ◽  
Author(s):  
Fang Fang ◽  
Rino Bellocco ◽  
Miguel A. Hernán ◽  
Weimin Ye
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Lateral Sclerosis

scholarly journals Edinburgh Cognitive and Behavioral Amyotrophic Lateral Sclerosis Screen (ECAS) in Norway: Protocol for validation and a prospective cohort study

2019 ◽  
Vol 14 ◽  
pp. 100347 ◽  
Author(s):  
Tina Taule ◽  
Annbjørg Spilde Morland ◽  
Marit Arnevik Renså ◽  
Jörg Aßmus ◽  
Ole-Bjørn Tysnes ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Lateral Sclerosis

The Natural Course and Risk Factors for Progression of Diabetic Retinopathy-KNDP Prospective Cohort Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1571-P
Author(s):  
HYUN UK MOON ◽  
JA YOUNG JEON ◽  
SOOJIN LEE ◽  
SEUNG JIN HAN ◽  
HAE JIN KIM ◽  
...  
Keyword(s):  
Risk Factors ◽  
Diabetic Retinopathy ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Natural Course
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