scholarly journals Transition from Restrictive to Obstructive Lung Function Impairment During Treatment and Follow-Up of Active Tuberculosis

2020 ◽  
Vol Volume 15 ◽  
pp. 1039-1047
Author(s):  
Brian W Allwood ◽  
Elizna Maasdorp ◽  
Grace J Kim ◽  
Christopher Cooper ◽  
Jonathan Goldin ◽  
...  

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259498
Author(s):  
Camila Thais Adam ◽  
Ione Jayce Ceola Schneider ◽  
Danielle Soares Rocha Vieira ◽  
Tauana Prestes Schmidt ◽  
Fernando Cesar Wehrmeister ◽  
...  

Background Fibrinogen is an important biomarker of inflammation, but findings from longitudinal studies that correlated fibrinogen with lung function in older adults are inconsistent. Aim To investigate the relationship between fibrinogen plasma levels and lung function impairment later in life. Methods Longitudinal analysis of 2,150 participants of the English Longitudinal Study of Ageing (ELSA) aged 50 years and older. Associations between changes in plasma fibrinogen between waves 2 (2004–05) and 4 (2008–09) and lung function in wave 6 (2012–13) were performed using multiple linear regression adjusted by potential confounders. Results Regarding the fibrinogen profile, 18.5% of the participants presented higher levels in both waves. In the adjusted models, the maintenance of high fibrinogen levels was associated with a significant reduction of lung function only for men. FEV1 showed a reduction of 0.17L, FVC of 0.22L, and the percentages predicted were 5.16% for FEV1 and 6.21% for FVC compared to those that maintained normal levels of fibrinogen. Discussion To the best of our knowledge, this was the first study investigating the relationship between changes in fibrinogen levels over a long follow-up period and lung function in older adults without pre-existing chronic diseases. ELSA has information on critical demographic and clinical parameters, which allowed to adjust for potential confounding factors. Conclusion It was found that the persistence of high levels of plasma fibrinogen in older English men, but not women, is associated with lung function decline. Therefore, plasma fibrinogen showed to be an important biomarker of pulmonary dysfunction in this population.





Pneumologie ◽  
2016 ◽  
Vol 70 (07) ◽  
Author(s):  
P Alter ◽  
RA Jörres ◽  
H Watz ◽  
T Welte ◽  
S Gläser ◽  
...  


Pneumologie ◽  
2018 ◽  
Vol 72 (S 01) ◽  
pp. S47-S48
Author(s):  
U Costabel ◽  
C Albera ◽  
KU Kirchgaessler ◽  
F Gilberg ◽  
U Petzinger ◽  
...  


2020 ◽  
pp. 100025
Author(s):  
Spyridon Fortis ◽  
Emily S. Wan ◽  
Ken Kunisaki ◽  
Patrick Tel Eyck ◽  
Zuhair K. Ballas ◽  
...  


2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Laurent Truffaut ◽  
Lucas Demey ◽  
Anne Violette Bruyneel ◽  
Alain Roman ◽  
Stephane Alard ◽  
...  

AbstractLung function impairment persists in 55% of critical COVID-19 patients three months after ICU discharge. Patient lung function, exercise capacity, radiologic, and quality of life data suggest impairment is related to radiologic lung involvement at admission.



Nutrients ◽  
2018 ◽  
Vol 10 (7) ◽  
pp. 919 ◽  
Author(s):  
Michele Arigliani ◽  
Alessandro Spinelli ◽  
Ilaria Liguoro ◽  
Paola Cogo

Experimental evidence from animal models and epidemiology studies has demonstrated that nutrition affects lung development and may have a lifelong impact on respiratory health. Chronic restriction of nutrients and/or oxygen during pregnancy causes structural changes in the airways and parenchyma that may result in abnormal lung function, which is tracked throughout life. Inadequate nutritional management in very premature infants hampers lung growth and may be a contributing factor in the pathogenesis of bronchopulmonary dysplasia. Recent evidence seems to indicate that infant and childhood malnutrition does not determine lung function impairment even in the presence of reduced lung size due to delayed body growth. This review will focus on the effects of malnutrition occurring at critical time periods such as pregnancy, early life, and childhood, on lung growth and long-term lung function.



1995 ◽  
Vol 6 (5) ◽  
pp. 495-497 ◽  
Author(s):  
M.B. Lund ◽  
J. Kongerud ◽  
O. Nome ◽  
A.F. Abrahamsen ◽  
Ø Bjπrtuft ◽  
...  


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