scholarly journals Development of an UPLC-MS/MS Method for the Quantitative Analysis of Upadacitinib in Beagle Dog Plasma and Pharmacokinetics Study

2021 ◽  
Vol Volume 15 ◽  
pp. 4167-4175
Author(s):  
Meng-Jie Wang ◽  
Yu-Hang Zhao ◽  
Chen Fan ◽  
Ying-Jie Wang ◽  
Xin-Qi Wang ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Beagle Dog ◽  
Pharmacokinetics Study ◽  
Dog Plasma

scholarly journals UPLC–MS/MS for the determination of azilsartan in beagle dog plasma and its application in a pharmacokinetics study

2015 ◽  
Vol 10 (3) ◽  
pp. 247-253 ◽  
Author(s):  
Cheng Gong ◽  
Junfeng Wang ◽  
Yinghua Sun ◽  
Dawei Ding ◽  
Lu Zhong ◽  
...  
Keyword(s):  
Beagle Dog ◽  
Pharmacokinetics Study ◽  
Dog Plasma

LC Determination of Helicidum in Beagle Dog Plasma: Study on the Pharmacokinetics of Helicidum Orally Disintegrating Tablets Compared to Conventional Tablets

2008 ◽  
Vol 68 (11-12) ◽  
pp. 1009-1012
Author(s):  
Jian-Chang He ◽  
Sheng-Hua Gu ◽  
Di Liu ◽  
Qing Zhang ◽  
En-Fu Feng ◽  
...  
Keyword(s):  
Beagle Dog ◽  
Orally Disintegrating Tablets ◽  
Dog Plasma

Analysis and pharmacokinetic study of polyphyllin H in beagle dog plasma after oral administration of Rhizoma Paridis extracts by LC-MS/MS

2014 ◽  
Vol 28 (12) ◽  
pp. 1869-1873
Author(s):  
Xingbin Yin ◽  
Longfei Lin ◽  
Mingrui Shen ◽  
Yujing Zhai ◽  
Sali Cao ◽  
...  
Keyword(s):  
Oral Administration ◽  
Pharmacokinetic Study ◽  
Beagle Dog ◽  
Dog Plasma

The Chiral Bioconversion and Pharmacokinetic Analysis of Trelagliptin in Beagle Dog Plasma by LC–MS/MS

2019 ◽  
Vol 58 (1) ◽  
pp. 31-36
Author(s):  
Li Zhou ◽  
Wang Xi ◽  
Hui Zhang ◽  
Lili Sun ◽  
Jinlong Yu ◽  
...  
Keyword(s):  
Internal Standard ◽  
Pharmacokinetic Profile ◽  
Gradient Elution ◽  
Ammonium Bicarbonate ◽  
Absolute Bioavailability ◽  
Pharmacokinetic Analysis ◽  
Beagle Dog ◽  
Dog Plasma ◽  
Liquid Chromatography Tandem Mass ◽  
Sensitivity Specificity

Abstract A simple and enantioselective method was developed and validated for the simultaneous determination of (R)- and (S)-trelagliptin in beagle dog plasma by chiral liquid chromatography tandem mass spectrometry. Trelagliptin enantiomers and (R)-rabeprazole (as internal standard, IS) were extracted from plasma samples by liquid–liquid extraction and separated on a CHIRALCEL OX-3R column using acetonitrile-5 ammonium bicarbonate as the mobile phase in gradient elution mode. The multiple reactions monitoring transitions of m/z 358.1→341.2 and 359.9→150.1 were used to quantify trelagliptin enantiomers and IS, respectively. This method was validated for sensitivity, specificity, linearity, precision, accuracy and stability of specific analytes under various conditions. And it was successfully applied to evaluating the pharmacokinetic profile of trelagliptin enantiomers in beagle dogs after single intravenous administration of (R)-trelagliptin injection (at 1 mg/kg) and oral administration (at 6.7 mg/kg). In this study, no chiral bioconversion of (R)-trelagliptin to (S)-trelagliptin in beagle dog plasma was observed. The absolute bioavailability of (R)-trelagliptin was identified to be 128.2%.

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