scholarly journals The relationship between serum-free insulin-like growth factor-1 and metabolic syndrome in school adolescents of northeast China

2019 ◽  
Vol Volume 12 ◽  
pp. 305-313
Author(s):  
Shuang Xie ◽  
Ranhua Jiang ◽  
Wanfeng Xu ◽  
Yu Chen ◽  
Lei Tang ◽  
...  

1999 ◽  
Vol 56 (6) ◽  
pp. 2076-2084 ◽  
Author(s):  
Jan Frystyk ◽  
Per Ivarsen ◽  
Christian Skjærbæk ◽  
Allan Flyvbjerg ◽  
Erling Bjerregaard Pedersen ◽  
...  


2012 ◽  
Vol 413 (3-4) ◽  
pp. 506-510 ◽  
Author(s):  
Jaewon Oh ◽  
Jong-Youn Kim ◽  
Sungha Park ◽  
Jong-Chan Youn ◽  
Nak Hoon Son ◽  
...  


1999 ◽  
Vol 9 (1) ◽  
pp. 74-80 ◽  
Author(s):  
Christian Skjærbæk ◽  
Jan Frystyk ◽  
Thorbjørn Grøfte ◽  
Allan Flyvbjerg ◽  
Moira S. Lewitt ◽  
...  




Circulation ◽  
1996 ◽  
Vol 94 (10) ◽  
pp. 2465-2471 ◽  
Author(s):  
Jan Frystyk ◽  
Christian Skjærbæk ◽  
Niels Alexander ◽  
Håkan Emanuelsson ◽  
Harry Suryapranata ◽  
...  




1991 ◽  
Vol 124 (5) ◽  
pp. 602-607 ◽  
Author(s):  
Ben A. A. Scheven ◽  
Nicola J. Hamilton

Abstract. Longitudinal growth was studied using an in vitro model system of intact rat long bones. Metatarsal bones from 18- and 19-day-old rat fetuses, entirely (18 days) or mainly (19 days) composed of chondrocytes, showed a steady rate of growth and radiolabelled thymidine incorporation for at least 7 days in serum-free media. Addition of recombinant human insulin-like growth factor-I to the culture media resulted in a direct stimulation of the longitudinal growth. Recombinant human growth hormone was also able to stimulate bone growth, although this was generally accomplished after a time lag of more than 2 days. A monoclonal antibody to IGF-I abolished both the IGF-I and GH-stimulated growth. However, the antibody had no effect on the growth of the bone explants in control, serum-free medium. Unlike the fetal long bones, bones from 2-day-old neonatal rats were arrested in their growth after 1-2 days in vitro. The neonatal bones responded to IGF-I and GH in a similar fashion as the fetal bones. Thus in this study in vitro evidence of a direct effect of GH on long bone growth via stimulating local production of IGF by the growth plate chondrocytes is presented. Furthermore, endogenous growth factors, others than IGFs, appear to play a crucial role in the regulation of fetal long bone growth.



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