scholarly journals Grip Strength as a Screening Index for Severe Degenerative Cervical Myelopathy in Primary Care: Development of Cutoff Values Using Receiver Operating Curve Analysis

2021 ◽  
Vol Volume 14 ◽  
pp. 9863-9872
Author(s):  
Hiroshi Kobayashi ◽  
Koji Otani ◽  
Takuya Nikaido ◽  
Kazuyuki Watanabe ◽  
Kinshi Kato ◽  
...  
Keyword(s):  
Primary Care ◽  
Grip Strength ◽  
Cervical Myelopathy ◽  
Curve Analysis ◽  
Receiver Operating Curve ◽  
Cutoff Values ◽  
Receiver Operating Curve Analysis ◽  
Degenerative Cervical Myelopathy ◽  
Care Development ◽  
Receiver Operating

scholarly journals Evaluation of the diagnostic value of platelet indices in pediatric acute appendicitis

2020 ◽  
Vol 48 (9) ◽  
pp. 030006052094651
Author(s):  
M. Murat Oktay ◽  
Mustafa Boğan ◽  
Selcan Türker Çolak ◽  
Mustafa Sabak ◽  
Hasan Gümüşboğa ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Negative Relationship ◽  
Diagnostic Value ◽  
Curve Analysis ◽  
Receiver Operating Curve ◽  
Platelet Indices ◽  
Receiver Operating Curve Analysis ◽  
Significant Difference ◽  
Wbc Count ◽  
Receiver Operating

Objective Abdominal examination findings in pediatric acute appendicitis (AA) significantly vary by age. Therefore, grading systems have been developed for diagnosing pediatric appendicitis, and laboratory and radiological findings have an important role in this diagnosis. However, there is a need to develop new parameters for diagnosing AA. This study aimed to investigate the diagnostic value of platelet indices in AA. Methods This retrospective, observational study included 207 pediatric patients who were admitted to the Emergency Department and operated on for AA. The patients were divided into three groups on the basis of their surgical and histopathological findings (non-AA, uncomplicated AA, and complicated AA). Results There was no significant difference in the mean platelet volume/platelet count (MPV/PC) ratio among the groups. The white blood cell (WBC) count and the MPV/PC ratio showed a significant negative relationship (r = −0.239). The specificity for MPV was 61.8% and the sensitivity was 68.8%. Receiver operating curve analysis of WBC and MPV showed significance for diagnosing AA. Conclusion There is a negative, but weak, relationship between the WBC count and the MPV/PC ratio. However, the MPV/PC ratio could be a useful parameter for diagnosing pediatric AA according to receiver operating curve analysis.

scholarly journals Composite Grip Strength as a Marker of Outcome in Patients Surgically Treated for Degenerative Cervical Myelopathy

2020 ◽  
Author(s):  
Arun John Paul ◽  
Rohit Amritanand ◽  
Prabakaran Margabandhu ◽  
Reka Karuppusami ◽  
Kenny Samuel David ◽  
...  
Keyword(s):  
Grip Strength ◽  
Cervical Myelopathy ◽  
Degenerative Cervical Myelopathy

scholarly journals Route to diagnosis of degenerative cervical myelopathy in a UK healthcare system: a retrospective cohort study

BMJ Open ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. e027000 ◽  
Author(s):  
Bryn Hilton ◽  
Jennifer Tempest-Mitchell ◽  
Benjamin Davies ◽  
Mark Kotter
Keyword(s):  
Primary Care ◽  
Cohort Study ◽  
Symptom Onset ◽  
Cervical Myelopathy ◽  
Secondary Care ◽  
Primary Outcome ◽  
Cord Compression ◽  
Cervical Cord ◽  
Clinical Documentation ◽  
Degenerative Cervical Myelopathy

ObjectivesDegenerative cervical myelopathy (DCM) presents insidiously, making initial diagnosis challenging. Surgery has been shown to prevent further disability but existing spinal cord damage may be permanent. Delays in surgery lead to increased disability and reduced postoperative improvements. Therefore, rapid surgical assessment is key to improving patient outcomes. Unfortunately, diagnosis of DCM in primary care is often delayed. This study aimed to characterise patients with DCM route to diagnosis and surgical assessment as well as to plot disease progression over time.DesignRetrospective, observational cohort study.SettingSingle, tertiary centre using additional clinical records from primary and secondary care centres.ParticipantsOne year of cervical MRI scans conducted at a tertiary neurosciences centre (n=1123) were screened for cervical cord compression, a corresponding clinical diagnosis of myelopathy and sufficient clinical documentation to plot a route to diagnosis (n=43).Primary outcome measuresTime to diagnosis from symptom onset, route to diagnosis and disease progression were the primary outcome measures in this study. Disease severity was approximated using a prospectively validated method for inferring modified Japanese Orthopaedic Association (i-mJOA) functional scoring from clinical documentation.ResultsPatients received a referral to secondary care 6.4±7.7 months after symptom onset. Cervical MRI scanning and neurosurgical review occurred 12.5±13.0 and 15.8±13.5 months after symptom onset, respectively. i-mJOA was 16.0±1.7 at primary care assessment and 14.8±2.5 at surgical assessment. 61.0% of patients were offered operations. For those who received surgery, time between onset and surgery was 22.1±13.2 months.ConclusionsRoute to surgical assessment was heterogeneous and lengthy. Some patients deteriorated during this period. This study highlights the need for a streamlined pathway by which patients with cervical cord compression can receive timely assessment and treatment by a specialist. This would improve outcomes for patients using existing treatments.

scholarly journals Prognostic Value of the Systemic Immune-Inflammation Index and Prognostic Nutritional Index in Patients With Medulloblastoma Undergoing Surgical Resection

2021 ◽  
Vol 8 ◽  
Author(s):  
Sihan Zhu ◽  
Zhuqing Cheng ◽  
Yuanjun Hu ◽  
Zhenghe Chen ◽  
Ji Zhang ◽  
...  
Keyword(s):  
Receiver Operating Characteristic ◽  
Surgical Resection ◽  
Operating Characteristic ◽  
Prognostic Nutritional Index ◽  
Curve Analysis ◽  
Prognostic Impact ◽  
Nutritional Index ◽  
Cutoff Values ◽  
Immune Inflammation ◽  
Receiver Operating

Background: The progression and metastasis of cancers are associated with systematic immune inflammation and nutritional dysfunction. The systemic immune-inflammation index and prognostic nutritional index (PNI) have shown a prognostic impact in several malignancies. Therefore, our study aimed to evaluate immune inflammation and nutritional index prognostic significance in patients with medulloblastoma (MB).Methods: We retrospectively analyzed 111 patients with MB between 2001 and 2021 at our institution. The optimal cutoff values for systemic immune-inflammation index (SII), neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte counts ration (MLR), and PNI were evaluated with receiver operating characteristic (ROC) curve analysis. Clinical characteristics and SII, NLR, MLR, and PNI were tested with the Pearson's chi-squared test. The Kaplan–Meier survival curves and the Cox proportional hazards model were used to evaluate the effects of immune inflammation and nutritional index on overall survival (OS).Results: Receiver operating characteristic curve analysis determined the optimal SII, NLR, MLR, and PNI cutoff values of 2,278, 14.83, 0.219, and 56.5 that significantly interacts with OS and divided the patients into two groups. Comparative survival analysis exhibited that the high-SII cohort had significantly shorter OS (p = 0.0048) than the low-SII cohort. For the univariate analysis, the results revealed that preoperative hydrocephalus (p = 0.01), SII (p = 0.006), albumin–bilirubin score (ALBI) (p = 0.04), and coSII–PNI were predictors of OS. In the multivariate analysis, preoperative hydrocephalus (p < 0.001), ALBI (p = 0.010), SII (p < 0.001), and coSII–PNI as independent prognostic factors were significantly correlated with OS.Conclusion: The preoperative SII, ALBI, and coSII–PNI serve as robust prognostic biomarkers for patients with MB undergoing surgical resection.

scholarly journals Construct validity, sensitivity and specificity of the USCD Performance-based Skill Assessment 2 in a mixed Portuguese sample

2019 ◽  
Author(s):  
Carolina da Motta ◽  
Célia Barreto Carvalho ◽  
Paula Castilho ◽  
Michele Pato
Keyword(s):  
Sensitivity And Specificity ◽  
Functional Assessment ◽  
Convergent Validity ◽  
Community Integration ◽  
Curve Analysis ◽  
Skill Assessment ◽  
Receiver Operating Curve ◽  
Optimal Cutoff ◽  
Portuguese Population ◽  
Receiver Operating Curve Analysis

This study explores the psychometric properties of the Portuguese USCD Performance-based Skill Assessment 2 (UPSA-2-PT) in a mixed sample or Portuguese participants. Inter-rater Reliability and internal consistency, convergent validity with community integration are described. A Receiver Operating Curve analysis establishes the sensitivity and specificity of scores, and an optimal cutoff value of functional capacity was established for the Portuguese population. These findings show an excellent the UPSA-2-PT integrity when compared to with previous studies carried out in Western countries. Thus, this is a useful tool for research and clinical purposes to practitioners in several fields that rely on functional assessment.<br>

scholarly journals Prognostic value of serum lactate dehydrogenase in hospitalized patients with Covid-19

2021 ◽  
Vol 29 (2) ◽  
pp. 131-141
Author(s):  
Vicente Aguadero ◽  
Elisa Nuez ◽  
Carlos García-Miralles ◽  
Gemma Sole-Enrech ◽  
Ruth Cano-Corres
Keyword(s):  
Predictive Value ◽  
Serum Lactate ◽  
Curve Analysis ◽  
Receiver Operating Curve ◽  
Serum Lactate Dehydrogenase ◽  
Ferritin Concentration ◽  
Predictive Values ◽  
Receiver Operating Curve Analysis ◽  
Predicting Outcome ◽  
Baseline Values

Abstract Background: Biochemical markers in COVID-19 remain to be defined. We analyzed the usefulness of LDH and ferritin in predicting outcome. Methods: This retrospective study analyzed ferritin and LDH concentrations obtained during the first 11 days of hospitalization in COVID-19 patients. We compared the change in ferritin and LDH concentrations obtained on each day of hospital admission with respect to baseline values between patients with favorable and unfavorable outcomes. We used receiver operating curve analysis to determine cutoffs for predicting outcomes. Results: We analyzed 387 patients. For determinations done on the 9th day, increases in LDH concentrations > 14.6% over the baseline yielded 80% positive predictive value, and a lack of increase yielded 96% negative predictive value for unfavorable outcomes. The change in ferritin concentration yielded lower predictive values. Conclusion: The percentage of change in LDH with respect to the baseline on the 9th day of hospitalization can predict outcome..

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