scholarly journals Evaluation of injectable silica-embedded nanohydroxyapatite bone substitute in a rat tibia defect model

2011 ◽  
pp. 1543 ◽  
Author(s):  
Weiguo Xu ◽  
Cornelia Ganz ◽  
Ulf Weber ◽  
Martin Adam ◽  
Daniel Wolter ◽  
...  
Keyword(s):  
Bone Substitute ◽  
Defect Model ◽  
Rat Tibia ◽  
Tibia Defect

Chemical Stability-Sensitive Osteoconductive Performance of Octacalcium Phosphate Bone Substitute in an Ovariectomized Rat Tibia Defect

2020 ◽  
Vol 3 (3) ◽  
pp. 1444-1458
Author(s):  
Kazuyoshi Baba ◽  
Yukari Shiwaku ◽  
Ryo Hamai ◽  
Yu Mori ◽  
Takahisa Anada ◽  
...  
Keyword(s):  
Chemical Stability ◽  
Bone Substitute ◽  
Octacalcium Phosphate ◽  
Ovariectomized Rat ◽  
Rat Tibia ◽  
Tibia Defect

Topical Application of Slow-Release Simvastatin as a Bone Substitute in Bone Defects in the Rat Tibia: A Pilot Study

2014 ◽  
Vol 29 (2) ◽  
pp. e241-e246 ◽  
Author(s):  
Heli Rushinek ◽  
Michael Alterman ◽  
Amir Laviv ◽  
Ervin I. Weiss ◽  
Michael Friedman ◽  
...  
Keyword(s):  
Pilot Study ◽  
Topical Application ◽  
Bone Substitute ◽  
Slow Release ◽  
Bone Defects ◽  
Rat Tibia

Bone substitute as an on-lay graft on rat tibia

2010 ◽  
Vol 21 (4) ◽  
pp. 424-429 ◽  
Author(s):  
A. Truedsson ◽  
J.-S. Wang ◽  
P. Lindberg ◽  
M. Gordh ◽  
B. Sunzel ◽  
...  
Keyword(s):  
Bone Substitute ◽  
Rat Tibia

Development of a bone nonunion in a noncritical segmental tibia defect model in sheep utilizing interlocking nail as an internal fixation system

2013 ◽  
Vol 183 (2) ◽  
pp. 620-628 ◽  
Author(s):  
Angel R. Lozada-Gallegos ◽  
Jorge Letechipia-Moreno ◽  
Icela Palma-Lara ◽  
Aldo Alessi Montero ◽  
Gerardo Rodríguez ◽  
...  
Keyword(s):  
Internal Fixation ◽  
Defect Model ◽  
Interlocking Nail ◽  
Bone Nonunion ◽  
Tibia Defect ◽  
Internal Fixation System ◽  
Fixation System

Comparison of Bone Substitutes in a Tibia Defect Model in Wistar-Rats

2011 ◽  
Vol 493-494 ◽  
pp. 732-738 ◽  
Author(s):  
Cornelia Ganz ◽  
W. Xu ◽  
G. Holzhüter ◽  
W. Götz ◽  
B. Vollmar ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Substitutes ◽  
Porous Matrix ◽  
Bovine Bone ◽  
New Bone Formation ◽  
Defect Model ◽  
Inflammatory Reactions ◽  
Nanocrystalline Hydroxyapatite ◽  
Defect Area ◽  
Tibia Defect

Various bone graft substitutes were used in clinical practise in the treatment of bone defects after trauma or osteoporosis. Many synthetic biomaterials were developed in recent years primarily based on hydroxyapatite (HA). NanoBone® is a nanocrystalline hydroxyapatite (HA) embedded in a porous matrix of silica (SiO2). The ratio of HA:SiO2 varied between 76:24 (wt%; NanoBone®) and 61:39 (wt%; Nanobone® S). The two bone substitutes NB and NB S and a natural bovine bone substitute Bio-Oss® (BO) were evaluated by means of implantation in the tibia of the rat. The aim of this study was to analyze the remodelling process and to measure new bone formation and degradation after implantation of these biomaterials. A tibia defect model was used for all investigations with testing periods of 12, 21 and 84 days. (n=5 for each time point). The results showed, that all bone grafts were well accepted by the host tissue without inflammatory reactions. In comparison to the biomaterial BO, NanoBone® and NanoBone® S were quickly degraded, whereas autologous proteins were incorporated into nanopores. New bone formation was statistically higher in NanoBone® S compared to Bio-Oss® in defect area after 84 days implantation. The presence of osteoclasts in tissue sections were demonstrated by TRAP- and ED1-immunohistology.

scholarly journals STIMULATORY CAPACITY OF AN OCTACALCIUM PHOSPHATE/GELATIN COMPOSITE ON BONE REGENERATION IN A RABBIT TIBIA DEFECT MODEL

2012 ◽  
Vol 26 (0) ◽  
pp. 53-58 ◽  
Author(s):  
Kentaro Suzuki ◽  
Yoshitomo Honda ◽  
Takahisa Anada ◽  
Takuto Handa ◽  
Naohisa Miyatake ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Octacalcium Phosphate ◽  
Defect Model ◽  
Rabbit Tibia ◽  
Stimulatory Capacity ◽  
Tibia Defect

Bone Grafting Putty – Animal Experiments and Clinical Applications

2012 ◽  
Vol 529-530 ◽  
pp. 285-290 ◽  
Author(s):  
Thomas Gerber ◽  
Cornelia Ganz ◽  
W. Xu ◽  
F. Maier ◽  
B. Frerich ◽  
...  
Keyword(s):  
Bone Graft ◽  
Animal Experiments ◽  
Bone Graft Substitute ◽  
Clinical Applications ◽  
Socket Preservation ◽  
Dental Application ◽  
New Material ◽  
Rat Tibia ◽  
High Level ◽  
Tibia Defect

The aim of the described study was to generate and evaluate a putty-like bone graft substitute ready to use for dental and orthopedic surgery. According to the asking of clinicians the new material should avoid the necessity of mixing blood and bone graft during the surgical process. Therefor the granulous material NanoBone® has been combined with a hydrogel based on Polyvinylpyrrolidone (PVP) and tested in standardized rat tibia defect over a period of 12 weeks and evaluated histologically. The results showed no limitations of the granulate characteristics in matrix change and hence a high level of vascularization and bone formation. An example for dental application shows the outcome in the case of socket preservation.

Application of a new bioresorbable film to guided bone regeneration in tibia defect model of the rabbits

2007 ◽  
Vol 82A (1) ◽  
pp. 256-262 ◽  
Author(s):  
Hong He ◽  
Jianqi Huang ◽  
Guanfu Chen ◽  
Yan Dong
Keyword(s):  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Defect Model ◽  
Tibia Defect

IN VIVO EVALUATION OF A NEW β-TRICALCIUM PHOSPHATE BONE SUBSTITUTE IN A RABBIT FEMUR DEFECT MODEL

2015 ◽  
Vol 27 (03) ◽  
pp. 1550028 ◽  
Author(s):  
Kam-Kong Chan ◽  
Chia-Hsien Chen ◽  
Lien-Chen Wu ◽  
Yi-Jie Kuo ◽  
Chun-Jen Liao ◽  
...  
Keyword(s):  
Bone Graft ◽  
Tricalcium Phosphate ◽  
Bone Substitute ◽  
Zealand White Rabbit ◽  
Bone Substitutes ◽  
Bone Graft Substitute ◽  
Defect Model ◽  
In Vivo Evaluation ◽  
Rabbit Femur

Calcium phosphate ceramics, of a similar composition to that of mineral bone, and which possess the properties of bioactivity and osteoconductivity, have been widely used as substitutes for bone graft in orthopedic, plastic and craniofacial surgeries. A synthetic β-tricalcium phosphate, Osteocera™, a recently developed bone graft substitute, has been used in this study. To evaluate the affinity and efficacy of Osteocera™ as bone defect implant, we used a New Zealand white rabbit femur defect model to test the osteoconductivity of this new bone substitute. Alternative commercially available bone substitutes, Triosite® and ProOsteon500, were used as the control materials. These three bone substitutes show good biocompatibility, and no abnormal inflammation either infection was seen at the implantation sites. In the histological and histomorphometric images, newly formed bone grew into the peripheral pores in the bone substitutes. After six months implantation, the volume of bone formation was found to be 20.5 ± 5.2%, 29.8 ± 6.5% and 75.5 ± 4.9% of the potential total cavity offered by ProOsteon500, Triosite® and Osteocera™, respectively. The newly formed bone area within the femur defect section for Osteocera™ was significantly larger than ProOsteon500 and Triosite®. We concluded that Osteocera™ shows better bioresorbability, biocompatibility and osteoconductivity in the rabbit femur defect model.

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