Topical Application of Slow-Release Simvastatin as a Bone Substitute in Bone Defects in the Rat Tibia: A Pilot Study

2014 ◽  
Vol 29 (2) ◽  
pp. e241-e246 ◽  
Author(s):  
Heli Rushinek ◽  
Michael Alterman ◽  
Amir Laviv ◽  
Ervin I. Weiss ◽  
Michael Friedman ◽  
...  
Keyword(s):  
Pilot Study ◽  
Topical Application ◽  
Bone Substitute ◽  
Slow Release ◽  
Bone Defects ◽  
Rat Tibia

Topical Application of Slow-Release Simvastatin as a Bone Substitute in Bone Defects in the Rat Tibia: A Pilot Study

2012 ◽  
Vol 2 (4) ◽  
pp. 303-308
Author(s):  
Heli Rushinek ◽  
Michael Alterman ◽  
Amir Laviv ◽  
Ervin Weiss ◽  
Michael Friedman ◽  
...  
Keyword(s):  
Pilot Study ◽  
Topical Application ◽  
Bone Substitute ◽  
Slow Release ◽  
Bone Defects ◽  
Rat Tibia

Bone tissue formation around two titanium implant surfaces placed in bone defects filled with bone substitute material or blood clot: A pilot study

2019 ◽  
Vol 21 (6) ◽  
pp. 1175-1180
Author(s):  
Guilherme dos Santos Trento ◽  
Rubens Spin‐Neto ◽  
Ana Paula Farnezi Bassi ◽  
Roberta Okamoto ◽  
Marisa Aparecida Cabrini Gabrielli ◽  
...  
Keyword(s):  
Pilot Study ◽  
Bone Tissue ◽  
Bone Substitute ◽  
Blood Clot ◽  
Titanium Implant ◽  
Bone Defects ◽  
Tissue Formation ◽  
Bone Substitute Material ◽  
Substitute Material ◽  
Bone Tissue Formation

scholarly journals Mechanistic Illustration: How Newly-Formed Blood Vessels Stopped by the Mineral Blocks of Bone Substitutes Can Be Avoided by Using Innovative Combined Therapeutics

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 952
Author(s):  
Fabien Bornert ◽  
François Clauss ◽  
Guoqiang Hua ◽  
Ysia Idoux-Gillet ◽  
Laetitia Keller ◽  
...  
Keyword(s):  
Regenerative Medicine ◽  
Bone Formation ◽  
Medicinal Product ◽  
Blood Vessels ◽  
Bone Substitute ◽  
Bone Substitutes ◽  
Bone Defects ◽  
New Bone Formation ◽  
Polymeric Component ◽  
Bone Filling

One major limitation for the vascularization of bone substitutes used for filling is the presence of mineral blocks. The newly-formed blood vessels are stopped or have to circumvent the mineral blocks, resulting in inefficient delivery of oxygen and nutrients to the implant. This leads to necrosis within the implant and to poor engraftment of the bone substitute. The aim of the present study is to provide a bone substitute currently used in the clinic with suitably guided vascularization properties. This therapeutic hybrid bone filling, containing a mineral and a polymeric component, is fortified with pro-angiogenic smart nano-therapeutics that allow the release of angiogenic molecules. Our data showed that the improved vasculature within the implant promoted new bone formation and that the newly-formed bone swapped the mineral blocks of the bone substitutes much more efficiently than in non-functionalized bone substitutes. Therefore, we demonstrated that our therapeutic bone substitute is an advanced therapeutical medicinal product, with great potential to recuperate and guide vascularization that is stopped by mineral blocks, and can improve the regeneration of critical-sized bone defects. We have also elucidated the mechanism to understand how the newly-formed vessels can no longer encounter mineral blocks and pursue their course of vasculature, giving our advanced therapeutical bone filling great potential to be used in many applications, by combining filling and nano-regenerative medicine that currently fall short because of problems related to the lack of oxygen and nutrients.

Effects of topical application of growth factors followed by microneedle therapy in women with female pattern hair loss: A pilot study

2012 ◽  
Vol 40 (1) ◽  
pp. 81-83 ◽  
Author(s):  
Young Bok Lee ◽  
Young Sun Eun ◽  
Ji Hae Lee ◽  
Min Seok Cheon ◽  
Yong Gyu Park ◽  
...  
Keyword(s):  
Growth Factors ◽  
Pilot Study ◽  
Topical Application ◽  
Hair Loss ◽  
Female Pattern Hair Loss

Bone substitute as an on-lay graft on rat tibia

2010 ◽  
Vol 21 (4) ◽  
pp. 424-429 ◽  
Author(s):  
A. Truedsson ◽  
J.-S. Wang ◽  
P. Lindberg ◽  
M. Gordh ◽  
B. Sunzel ◽  
...  
Keyword(s):  
Bone Substitute ◽  
Rat Tibia

scholarly journals Reconstruction of anterior frontal wall and contours defects using bone substitute

2021 ◽  
pp. 34
Author(s):  
Keyword(s):  
Bone Substitute ◽  
Calcium Sulfate ◽  
Donor Site ◽  
Bone Defects ◽  
Autogenous Bone ◽  
Bone Void Filler ◽  
Custom Made ◽  
Cranial Implant ◽  
Bone Void ◽  
Orbital Area

Aim: The aim of this article is to report on the safety and long-term efficacy of Cerament® BoneVoid Filler bone substitute for repairing craniofacial bone defects. Post-traumatic cranioplasty is a complex and challenging procedure for all maxillo-craniofacial surgeons and neurosurgeons, especially when repairing large areas. The standard criterion for repairing small cranial defects is the use autogenous bone from the iliac crest or split calvarial grafts. Autogenous grafts may result in donor-site morbidity, increased surgical time, reabsorption, blood loss, and longer recovery time . Alloplastic materials used for bone repair, such as methyl methacrylate, hydroxyapatite, titanium, or porous polyethylene, are expected to have optimal properties, including easy adaptation, biocompatibility, ingrowth of new tissue, stability of shape, and low rate of reabsorption. A cranial implant should be easily shaped and positioned, allowing easy tissue growth. In very wide cranium defects the new technology is a custom made cranial implant constructed three-dimensionally with different types of materials. However, this procedure is very expensive with various infection rates depending on the kind of material used and on the chemicophysical composition of the implant. Methods: The authors report the case of a 50-year-old man with a severe deformity of the forehead-supra orbital area as a result of a previous complex fronto-facial trauma treated in an emergency Unit. Secondary correction and reconstruction of the residual deformities were performed by using Cerament® Bone Void Filler, an alloplastic biphasic material, composed of 40% hydroxyapatite, 60% calcium sulfate and the radio-contrast agent iohexol. The unique ratio of hydroxyapatite and calcium sulfate is designed to enable Cerament to resorb at the same rate that bone forms. Calcium sulfate acts as a resorbable carrier for hydroxyapatite which is highly osteoconductive, promoting bone ingrowth.It seems to be a promising bone graft substitute in the management of bony irregularities in the fronto-orbital area. Conclusion: The patient was first hospitalized as the result of a serious craniofacial trauma. One year after the first emergency cranio-orbital reconstructive operation, a marked deformity of the frontal region appeared with a “grid effect” due to the inadequate plate-bony fixation of the fractures applied during the first bony recomposition and because it was not as rigid as it should have been . A secondary surgery for deformity correction was performed. The hardware was totally removed and the bony deformity smoothed, reshaped, covered and filled using Cerament® Bone Void Filler, a biomaterial. The patient recovered with a satisfactory cranium-forehead shape, no complications, and complete disappearance of a frowning look of the fronto-orbital region. Recently, increased use of bone substitutes in the reconstruction of bone defects has been fuelled by donor site complications associated with autologous bone harvesting. Cerament® BoneVoid Filler is a biphasic and injectable bone substitute that has a highly compressive strength and the ability to promote cancellous bone healing

scholarly journals Can Pixel Value Ratio be Used in the Assessment of Ceramic Bone Substitute Incorporation? Observations from a Pilot Study

2017 ◽  
Vol 82 ◽  
pp. 706-712
Author(s):  
Balasubramanian Balakumar ◽  
Anitha Jasper ◽  
Roshan S. Livingstone ◽  
Sangeet Gangadharan ◽  
Sridhar Gibikote ◽  
...  
Keyword(s):  
Pilot Study ◽  
Bone Substitute ◽  
Pixel Value

Fully Interconnected Globular Porous Biphasic Calcium Phosphate Ceramic Scaffold Facilitates Osteogenic Repair

2007 ◽  
Vol 361-363 ◽  
pp. 119-122 ◽  
Author(s):  
J.H. Lim ◽  
J.H. Park ◽  
Eui Kyun Park ◽  
Hae Jung Kim ◽  
Il Kyu Park ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Substitute ◽  
Biphasic Calcium Phosphate ◽  
Bone Defects ◽  
Calcium Phosphate Ceramic ◽  
Ceramic Scaffold ◽  
Porous Biphasic Calcium Phosphate

An appropriate scaffold, which provides structural support for transplanted cells and acts as a vehicle for the delivery of biologically active molecules, is critical for tissue engineering. We developed a fully interconnected globular porous biphasic calcium phosphate ceramic scaffold by adopting a foaming method, and evaluated its efficiency as a bone substitute and a scaffold for bone tissue engineering by in vitro and in vivo biocompatible analysis and its osteogenic healing capacity in rat tibial bone defects. They have spherical pores averaging 400um in diameter and interconnecting interpores averaging 70um in diameter with average 85% porosity. They elicited no cytotoxicity and noxious effect on cellular proliferation and osteoblastic differentiation during the cell-scaffold construct formation. Also the bone defects grafted with fully interconnected globular porous biphasic calcium phosphate ceramic blocks revealed excellent bone healing within 3 weeks. These findings suggest that the fully interconnected porous biphasic calcium phosphate scaffold formed by the foaming method can be a promising bone substitute and a scaffold for bone tissue engineering.

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