Bone Grafting Putty – Animal Experiments and Clinical Applications

2012 ◽  
Vol 529-530 ◽  
pp. 285-290 ◽  
Author(s):  
Thomas Gerber ◽  
Cornelia Ganz ◽  
W. Xu ◽  
F. Maier ◽  
B. Frerich ◽  
...  
Keyword(s):  
Bone Graft ◽  
Animal Experiments ◽  
Bone Graft Substitute ◽  
Clinical Applications ◽  
Socket Preservation ◽  
Dental Application ◽  
New Material ◽  
Rat Tibia ◽  
High Level ◽  
Tibia Defect

The aim of the described study was to generate and evaluate a putty-like bone graft substitute ready to use for dental and orthopedic surgery. According to the asking of clinicians the new material should avoid the necessity of mixing blood and bone graft during the surgical process. Therefor the granulous material NanoBone® has been combined with a hydrogel based on Polyvinylpyrrolidone (PVP) and tested in standardized rat tibia defect over a period of 12 weeks and evaluated histologically. The results showed no limitations of the granulate characteristics in matrix change and hence a high level of vascularization and bone formation. An example for dental application shows the outcome in the case of socket preservation.

A Review of Bone Graft Substitutes Made From HA-Polymer Composite Scaffolds and Fabrication Potential With Laser-Based Additive Manufacturing Processes

2015 ◽  
Author(s):  
Hera Wu ◽  
Shuting Lei
Keyword(s):  
Additive Manufacturing ◽  
Bone Graft ◽  
Three Dimensional ◽  
Bone Graft Substitute ◽  
Biological Properties ◽  
Porous Scaffolds ◽  
Composite Scaffolds ◽  
Bone Graft Substitutes ◽  
Manufacturing Technologies ◽  
High Level

Hydroxyapatite, a bioactive ceramic, has been combined with biodegradable polymers to create composite three-dimensional interconnected porous scaffolds for bone graft substitutes. The materials and fabrication methods of these composite scaffolds are reviewed. The resulting mechanical and biological properties of scaffolds produced from the combination of certain materials and fabrication methods are analyzed. Requirements for a bone graft substitute and third generation scaffolds with the addition of osteoinductive and osteogenic features to composite scaffolds including biomolecule delivery and cell seeding are also introduced. Finally, the benefits of using additive manufacturing technologies to enable high level of control over the design of interconnected pore structure are discussed.

COGNITIVIZATION — THE NEXT STAGE OF INFORMATIZATION OF EDUCATION

2018 ◽  
pp. 5-11
Author(s):  
A. S. Christochevskaya ◽  
S. A. Christochevsky
Keyword(s):  
Comparative Analysis ◽  
Learning Resources ◽  
Technical Base ◽  
Initial Stage ◽  
New Knowledge ◽  
Good Material ◽  
E Learning ◽  
New Material ◽  
High Level ◽  
Paper Method

Informatization of education has been going on for 30 years. During this time, a good material and technical base appeared in schools, there are repositories of e-learning resources to which teachers have access. However, it is difficult to use these e-learning resources due to their too large number and not always high level. It is advisable to introduce a system of reviews and recommendations, to conduct a comparative analysis, as well as to make reviews of resources on a particular subject/topic. In addition, the demand for e-learning resources is affected by the fact that education authorities encourage not so much the use of e-learning resources as their development by the teacher himself. In general, the load on teachers has increased instead of the promised saving of time and effort when using the e-learning resources. At the same time, many e-learning resources are not very effective, since they do not meet the requirements of cognitiveness (they contribute not to learning, but to simple memorization of the material). It is necessary to explore the process of learning new material: this will allow you to create cognitive e-learning resources and other resources that would help you with equal probability to successfully acquire new knowledge for students belonging to different psycho-types. At the initial stage of the study of any subject, it is more expedient to use the usual “paper” method, that is, a textbook and not overload the student’s brain with excessive information. Only when he has mastered the basic provisions, we can turn to e-learning resources, bearing in mind that they must be cognitive, that is, they are aimed at logical perception and rapid intuitive learning, only in this case e-learning resources can be considered effective. The conclusion is formulated that cognitiveness is the next stage of informatization of education after the stage of electronization.

scholarly journals Development and physicochemical characterization of novel porous phosphate glass bone graft substitute and in vitro comparison with xenograft

2021 ◽  
Vol 32 (6) ◽  
Author(s):  
Niketa Chauhan ◽  
Nilay Lakhkar ◽  
Amol Chaudhari
Keyword(s):  
Cell Proliferation ◽  
Physicochemical Properties ◽  
Bone Graft ◽  
Phosphate Glass ◽  
Physicochemical Characterization ◽  
Bone Graft Substitute ◽  
Organic Content ◽  
In Vitro Cytotoxicity ◽  
Porous Phosphate

AbstractThe process of bone regeneration in bone grafting procedures is greatly influenced by the physicochemical properties of the bone graft substitute. In this study, porous phosphate glass (PPG) morsels were developed and their physicochemical properties such as degradation, crystallinity, organic content, surface topography, particle size and porosity were evaluated using various analytical methods. The in vitro cytotoxicity of the PPG morsels was assessed and the interaction of the PPG morsels with Dental Pulp Stem Cells (DPSCs) was studied by measuring cell proliferation and cell penetration depth. The cell-material interactions between PPG morsels and a commercially available xenograft (XG) were compared. The PPG morsels were observed to be amorphous, biocompatible and highly porous (porosity = 58.45%). From in vitro experiments, PPG morsels were observed to be non-cytotoxic and showed better cell proliferation. The internal surface of PPG was easily accessible to the cells compared to XG.

scholarly journals 405 Radiological Analysis of Gentamicin Eluting Synthetic Bone Graft Substitute Used in The Management of Gustilo IIIB Open Fractures

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
A Aljawadi ◽  
I Madhi ◽  
T Naylor ◽  
M Elmajee ◽  
A Islam ◽  
...  
Keyword(s):  
Bone Graft ◽  
Cortical Thickness ◽  
Bone Graft Substitute ◽  
Fracture Site ◽  
Open Fractures ◽  
X Rays ◽  
Radiographic Images ◽  
Synthetic Bone ◽  
Synthetic Bone Graft

Abstract Background Management of traumatic bone void associated with Gustilo IIIB open fractures is challenging. Gentamicin eluting synthetic bone graft substitute (Cerament-G) had been recently utilised for the management of patients with these injuries. This study aims to assess radiological signs of Cerament-G remodelling. Method Retrospective data analysis of all patients admitted to our unit with IIIB open fractures who had Cerament-G applied as avoid filler. Postoperative radiographic images of the fracture site at 6-weeks, 3-months, 6-months and at the last follow-up were reviewed. The radiological signs of Cerament-G integration, percent of void healing, and bone cortical thickness at the final follow-up were assessed. Results 34 patients met our inclusion criteria, mean age: 42 years. Mean follow-up time was 20 months. 59% of patients had excellent (>90%) void filling, 26.4% of patients had 50-90% void filling, and 14.6% had < 50% void filling. Normal bone cortical thickness was restored on AP and Lateral views in 55.8% of patients. No residual Cerement-G was seen on X-rays at the final follow-up in any of the patients. Conclusions Our results showed successful integration of Cerament-G with excellent void filling and normal cortical thickness achieved in more than half of the patients.

Biology of sinus floor augmentation with an autograft vs. a bone graft substitute in a preclinical in vivo experimental model

2021 ◽  
Author(s):  
Benjamin R. Coyac ◽  
Meagan Wu ◽  
Daniel J. Bahat ◽  
Benjamin J. Wolf ◽  
Jill A. Helms
Keyword(s):  
Bone Graft ◽  
Experimental Model ◽  
Bone Graft Substitute ◽  
Sinus Floor Augmentation ◽  
Sinus Floor

Osteogrow: A Novel Bone Graft Substitute for Orthopedic Reconstruction

2017 ◽  
pp. 215-228 ◽  
Author(s):  
Lovorka Grgurevic ◽  
Igor Erjavec ◽  
Ivo Dumic-Cule ◽  
Tatjana Bordukalo-Niksic ◽  
Martina Pauk ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Graft Substitute
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