scholarly journals Hybrid Membrane Nanovaccines Combined with Immune Checkpoint Blockade to Enhance Cancer Immunotherapy

2022 ◽  
Vol Volume 17 ◽  
pp. 73-89
Author(s):  
Peiqi Zhao ◽  
Yuanlin Xu ◽  
Wei Ji ◽  
Lanfang Li ◽  
Lihua Qiu ◽  
...  
Cancers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 5912
Author(s):  
Angèle Luby ◽  
Marie-Clotilde Alves-Guerra

Over the past decade, advances in cancer immunotherapy through PD1–PDL1 and CTLA4 immune checkpoint blockade have revolutionized the management of cancer treatment. However, these treatments are inefficient for many cancers, and unfortunately, few patients respond to these treatments. Indeed, altered metabolic pathways in the tumor play a pivotal role in tumor growth and immune response. Thus, the immunosuppressive tumor microenvironment (TME) reprograms the behavior of immune cells by altering their cellular machinery and nutrient availability to limit antitumor functions. Today, thanks to a better understanding of cancer metabolism, immunometabolism and immune checkpoint evasion, the development of new therapeutic approaches targeting the energy metabolism of cancer or immune cells greatly improve the efficacy of immunotherapy in different cancer models. Herein, we highlight the changes in metabolic pathways that regulate the differentiation of pro- and antitumor immune cells and how TME-induced metabolic stress impedes their antitumor activity. Finally, we propose some drug strategies to target these pathways in the context of cancer immunotherapy.


2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 3051-3051 ◽  
Author(s):  
Dmitriy Zamarin ◽  
Rikke Baek Holmgaard ◽  
Sumit Kumar Subudhi ◽  
Joon-Seok Park ◽  
Mena Mansour ◽  
...  

2017 ◽  
Vol 13 (4) ◽  
pp. 195-207 ◽  
Author(s):  
David J. Byun ◽  
Jedd D. Wolchok ◽  
Lynne M. Rosenberg ◽  
Monica Girotra

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