scholarly journals Synergistic effect of regenerating agent plus cord blood serum eye drops for the treatment of resistant neurotrophic keratitis: a case report and a hypothesis for pathophysiologic mechanism

2015 ◽  
pp. 277 ◽  
Author(s):  
Giuseppe Giannaccare ◽  
Michela Fresina ◽  
Aldo Vagge ◽  
Piera Versura
Keyword(s):  
Case Report ◽  
Synergistic Effect ◽  
Blood Serum ◽  
Cord Blood ◽  
Eye Drops ◽  
Cord Blood Serum ◽  
Pathophysiologic Mechanism ◽  
Neurotrophic Keratitis ◽  
Serum Eye Drops

Efficacy of 2-Month Treatment With Cord Blood Serum Eye Drops in Ocular Surface Disease

Cornea ◽  
2017 ◽  
Vol 36 (8) ◽  
pp. 915-921 ◽  
Author(s):  
Giuseppe Giannaccare ◽  
Marina Buzzi ◽  
Michela Fresina ◽  
Claudio Velati ◽  
Piera Versura
Keyword(s):  
Blood Serum ◽  
Cord Blood ◽  
Ocular Surface ◽  
Ocular Surface Disease ◽  
Eye Drops ◽  
Cord Blood Serum ◽  
Serum Eye Drops

Comparison of growth factor and interleukin content of adult peripheral blood and cord blood serum eye drops for cornea and ocular surface diseases

2018 ◽  
Vol 57 (4) ◽  
pp. 549-555 ◽  
Author(s):  
M. Buzzi ◽  
P. Versura ◽  
B. Grigolo ◽  
C. Cavallo ◽  
A. Terzi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Blood Serum ◽  
Cord Blood ◽  
Peripheral Blood ◽  
Ocular Surface ◽  
Eye Drops ◽  
Cord Blood Serum ◽  
Ocular Surface Diseases ◽  
Adult Peripheral Blood ◽  
Serum Eye Drops

PP-036 Preparation of an experimental cord blood serum eye drops for topical use in severe corneal epitheliopathy

2015 ◽  
Vol 22 (Suppl 1) ◽  
pp. A131.1-A131
Author(s):  
A Stancari ◽  
AM Guarguaglini ◽  
S Maselli ◽  
G Bersani ◽  
C Puggioli
Keyword(s):  
Blood Serum ◽  
Cord Blood ◽  
Eye Drops ◽  
Cord Blood Serum ◽  
Serum Eye Drops

scholarly journals Cord Blood Serum (CBS)-Based Eye Drops Modulate Light-Induced Neurodegeneration in Albino Rat Retinas

Biomolecules ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 678
Author(s):  
Stefano Di Marco ◽  
Serena Riccitelli ◽  
Mattia Di Paolo ◽  
Emilio Campos ◽  
Marina Buzzi ◽  
...  
Keyword(s):  
Blood Serum ◽  
Cord Blood ◽  
Retinal Degeneration ◽  
Hot Spot ◽  
Age Related Macular Degeneration ◽  
Trophic Factors ◽  
Albino Rats ◽  
Protective Mechanism ◽  
Eye Drops ◽  
Cord Blood Serum

Age-related macular degeneration (AMD) is one of the leading causes of visual loss in western countries, it has no cure, and its incidence will grow in the future, for the overall population aging. Albino rats with retinal degeneration induced by exposure to high-intensity light (light-damage, LD) have been extensively used as a model of AMD to test neuroprotective agents. Among them, trophic factors (NGF and BDNF) have been shown to play a significant role in photoreceptors’ survival. Interestingly, cord blood serum (CBS) is an extract full of chemokines and trophic factors; we, therefore, hypothesized that CBS could be an excellent candidate for neuroprotection. Here, we investigate whether CBS-based eye drops might mitigate the effects of light-induced retinal degeneration in albino rats. CBS treatment significantly preserved flash-electroretinogram (f-ERG) response after LD and reduced the “hot-spot” extension. Besides, CBS-treated animals better preserved the morphology of the outer nuclear layer, together with a reduction in microglia migration and activation. Interestingly, the treatment did not modulate reactive gliosis and activation of the self-protective mechanism (FGF2). In conclusion, our results suggest that CBS-based eye drops might be successfully used to mitigate retinal neurodegenerative processes such as AMD.

scholarly journals Topical Treatment with Cord Blood Serum in Glaucoma Patients: A Preliminary Report

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Emilio Campos ◽  
Piera Versura ◽  
Giuseppe Giannaccare ◽  
Adriana Terzi ◽  
Silvia Bisti ◽  
...  
Keyword(s):  
Blood Serum ◽  
Cord Blood ◽  
Vision Loss ◽  
Visual Fields ◽  
Field Tests ◽  
Mean Deviation ◽  
Eye Drops ◽  
Cord Blood Serum ◽  
Retrospective Data Analysis ◽  
Before And After

Purpose. To report data which happened to be observed in two glaucoma patients treated with Cord Blood Serum (CBS) eye drops. Design. A case report and retrospective data analysis. Methods. CBS topical eye drops, characterized in advance for growth factors (GFs) content, were administered for two months with the aim to relieve their subjective symptoms, in two patients who had referred ocular surface discomfort, although in absence of any sign of keratopathy. As patients were also affected by advanced glaucoma at risk of vision loss and under treatment with hypotensive drugs, they had been also monitored over the same period with IOP controls and visual field tests in our unit. Results. During subsequent visits, data from Mean Deviation and Pattern Standard Deviation in the visual fields were retrospectively collected and compared with before and after treatment with CBS, and an amelioration was observed. Conclusions. CBS contains a combination of GFs, which potentially exert a neuroprotective action and elect CBS as an interesting natural source to be delivered in neurodegenerative ocular disorders. The incidentally observed amelioration in these two patients deserves further investigation in this respect.

scholarly journals Association between Several Persistent Organic Pollutants and Thyroid Hormone Levels in Cord Blood Serum and Bloodspot of the Newborn Infants of Korea

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0125213 ◽  
Author(s):  
Sunmi Kim ◽  
Jeongim Park ◽  
Hai-Joong Kim ◽  
Jeong Jae Lee ◽  
Gyuyeon Choi ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Blood Serum ◽  
Cord Blood ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Newborn Infants ◽  
Hormone Levels ◽  
Cord Blood Serum ◽  
Thyroid Hormone Levels
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