scholarly journals Donafenib-Loaded Callispheres Beads Embolization in a VX2 Liver Tumor: Investigating Efficacy, Safety, and Improvement of Tumor Angiogenesis After Embolization

2021 ◽  
Vol Volume 8 ◽  
pp. 1525-1535
Author(s):  
Tongqiang Li ◽  
Qin Shi ◽  
Jiacheng Liu ◽  
Yingliang Wang ◽  
Chen Zhou ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Tumor Angiogenesis

scholarly journals Preparation of microspheres encapsulating sorafenib and catalase and their application in rabbit VX2 liver tumor

2020 ◽  
Author(s):  
Xihan Li ◽  
Hui Yu ◽  
Ying Huang ◽  
Yu Chen ◽  
Jialun Wang ◽  
...  
Keyword(s):  
Hepatic Artery ◽  
Liver Tumor ◽  
Tumor Angiogenesis ◽  
Liver Tumors ◽  
Tumor Hypoxia ◽  
Diffusion Method ◽  
Advanced Hepatocellular Carcinoma ◽  
Secondary Tumor

Abstract Background: Transcatheter arterial chemoembolization (TACE) is extensively used in the treatment of advanced hepatocellular carcinoma (HCC). However, the efficacy of TACE is usually limited to secondary tumor hypoxia and hypoxia-related tumor angiogenesis. Methods: In this study, poly(lactic-co-glycolic acid) (PLGA) microspheres ( SO R-CAT-PLGA MSs) encapsulating sorafenib (SOR) and catalase (CAT) were prepared by double-emulsion solvent diffusion method. Sorafenib inhibits tumor angiogenesis, and catalase decomposes hydrogen peroxide (H 2 O 2 ) to generate oxygen in the tumor. Results: In vitro and in vivo , SOR -CAT-PLGA MSs could significantly improve the efficacy of hepatic artery embolization in the treatment of rabbit VX2 liver tumors, regulate tumor hypoxia and immunosuppressive microenvironment, then achieved near-complete and rapid necrosis of liver tumors. Conclusions: The application of new SOR -CAT-PLGA MSs in hepatic artery chemoembolization of rabbit VX2 liver tumor is a promising approach to improve the therapeutic effect of liver tumors and has a broad clinical application prospect.

scholarly journals CD133+ liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling

Hepatology ◽  
2012 ◽  
Vol 55 (3) ◽  
pp. 807-820 ◽  
Author(s):  
Kwan Ho Tang ◽  
Stephanie Ma ◽  
Terence K. Lee ◽  
Yuen Piu Chan ◽  
Pak Shing Kwan ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Tumor Angiogenesis ◽  
Interleukin 8 ◽  
Tumor Initiating Cells ◽  
Self Renewal ◽  
Promote Tumor Angiogenesis

Extracellular matrix: the gatekeeper of tumor angiogenesis

2019 ◽  
Vol 47 (5) ◽  
pp. 1543-1555 ◽  
Author(s):  
Maurizio Mongiat ◽  
Simone Buraschi ◽  
Eva Andreuzzi ◽  
Thomas Neill ◽  
Renato V. Iozzo
Keyword(s):  
Extracellular Matrix ◽  
Tumor Angiogenesis ◽  
Signaling Cascades ◽  
Cancer Growth ◽  
Cell Behavior ◽  
Metastatic Progression ◽  
Surface Receptors ◽  
The Matrix ◽  
Multiple Signaling

Abstract The extracellular matrix is a network of secreted macromolecules that provides a harmonious meshwork for the growth and homeostatic development of organisms. It conveys multiple signaling cascades affecting specific surface receptors that impact cell behavior. During cancer growth, this bioactive meshwork is remodeled and enriched in newly formed blood vessels, which provide nutrients and oxygen to the growing tumor cells. Remodeling of the tumor microenvironment leads to the formation of bioactive fragments that may have a distinct function from their parent molecules, and the balance among these factors directly influence cell viability and metastatic progression. Indeed, the matrix acts as a gatekeeper by regulating the access of cancer cells to nutrients. Here, we will critically evaluate the role of selected matrix constituents in regulating tumor angiogenesis and provide up-to-date information concerning their primary mechanisms of action.

Suppression of mouse colon tumor angiogenesis by the INK4a/ARF locus

2001 ◽  
Vol 120 (5) ◽  
pp. A296-A296
Author(s):  
C DAI ◽  
G STEVENL ◽  
M GEE ◽  
W LEE ◽  
H LEE ◽  
...  
Keyword(s):  
Tumor Angiogenesis ◽  
Colon Tumor ◽  
Mouse Colon

Role of Protein kinase D2 in pancreatic tumor growth and tumor angiogenesis

2010 ◽  
Vol 48 (08) ◽  
Author(s):  
N Azoitei ◽  
GV Pusapati ◽  
A Kleger ◽  
C Brunner ◽  
F Genze ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Tumor Growth ◽  
Tumor Angiogenesis ◽  
Pancreatic Tumor

Primary hepatic actinomycosis mimicking malign liver tumor

2013 ◽  
Vol 34 (S 01) ◽  
Author(s):  
K Beller ◽  
H Weiler ◽  
B Riecken ◽  
K Caca
Keyword(s):  
Liver Tumor ◽  
Hepatic Actinomycosis

A 67-Year-Old Man with Hepatitis C Virus Infection and a Liver Tumor

2000 ◽  
Vol 20 (02) ◽  
pp. 227-232 ◽  
Author(s):  
Arief Suriawinata ◽  
Katya Ivanov ◽  
Menahem Ben Haim ◽  
Myron E. Schwartz
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Liver Tumor ◽  
Hepatitis C Virus Infection

Clinical Application of Radiofrequency Ablation for Malignant Liver Tumor during Interruption of Hepatic Blood Flow

2000 ◽  
Vol 18 ◽  
pp. 121-125
Author(s):  
Takashi Shibata ◽  
Takahiro Niinobu ◽  
Masashi Kitada ◽  
Takashi Shimano ◽  
Motohisa Takami ◽  
...  
Keyword(s):  
Blood Flow ◽  
Radiofrequency Ablation ◽  
Clinical Application ◽  
Hepatic Blood Flow ◽  
Liver Tumor ◽  
Malignant Liver Tumor ◽  
Malignant Liver
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