scholarly journals Cognitive Function and White Matter Lesions in Medication-Overuse Headache

2021 ◽  
Vol Volume 14 ◽  
pp. 1845-1853
Author(s):  
Yue Xiang ◽  
Shenggen Chen ◽  
Hanbin Lin ◽  
Wenting Xiong ◽  
Zhenyang Zheng
Keyword(s):  
Cognitive Function ◽  
White Matter ◽  
Medication Overuse ◽  
Medication Overuse Headache ◽  
White Matter Lesions

White matter lesions in chronic migraine with medication overuse headache: a cross-sectional MRI study

2014 ◽  
Vol 261 (4) ◽  
pp. 784-790 ◽  
Author(s):  
Zhenyang Zheng ◽  
Zijian Xiao ◽  
Xiaolei Shi ◽  
Minghui Ding ◽  
Wei Di ◽  
...  
Keyword(s):  
White Matter ◽  
Chronic Migraine ◽  
Medication Overuse ◽  
Medication Overuse Headache ◽  
White Matter Lesions ◽  
Cross Sectional ◽  
Mri Study

Abstract WMP78: The Efficacy of Angiotensin II Peptide Vaccination Against White Matter Lesions of Vascular Dementia in Rats

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Kouji Wakayama ◽  
Munehisa Shimamura ◽  
Hironori Nakagami ◽  
Ryuichi Morishita
Keyword(s):  
Endothelial Cells ◽  
Cognitive Function ◽  
Angiotensin Ii ◽  
White Matter ◽  
Western Blot ◽  
Vascular Dementia ◽  
White Matter Lesions ◽  
Ang Ii ◽  
Peptide Vaccination ◽  
Brdu Assay

Background & Purposes: There had been no attempt to show the efficacy of therapeutic vaccination in vascular dementia. A rat model of vascular dementia was prepared by bilateral common carotid artery ligation (2VO). The purpose of this study is to investigate whether pre-exposure Angiotensin II (Ang II) peptide vaccination exhibits the protective effects against white matter lesions (WML) in 2VO rats. Methods: After subcutaneous injection of Ang II peptide vaccine (10μg/200μl) or saline (200μl) to Wistar rats (male) at the time point of 6, 8 and 10 week-old, 2VO or sham surgery was performed at 12 week-old. Cognitive function was evaluated after 14 days of 2VO using the novel object recognition (NOR) test. Anti-Ang II antibody (Ab) level was quantified using ELISA. Histological examinations of WML and demyelination in the corpus callosum (CC) were evaluated using immunohistochemistry (IHC), 5-bromodeoxyuridine (BrdU) assay and Klüver-Barrera staining. Western blot analyses of VCAM-1, FGF2, phospho-CREB and CREB using proteins extracted from CC were performed to investigate the mechanism of restoration of WML by Ang II vaccination. Results: Histological examinations presented that exacerbation of WML and demyelination observed in saline treated (S) rats was ameliorated in Ang II vaccinated (V) rats. The results of NOR test indicated that cognitive dysfunction observed in S rats was improved in V rats at 14 days after 2VO. Expression of VCAM-1 in CC of S rats was significantly reduced in V rats at 7 days after 2VO. BrdU assay exhibited that vaccination accelerated the differentiation of oligodendrocyte progenitor cells (OPCs) in WML from 14 days to 28 days of 2VO. Western blot presented that both CREB phosphorylation and FGF2 expression in CC were increased in V rats compared with S rats at 14 days after 2VO. Double IHC showed that FGF2 expressing cells were mostly endothelial cells and astrocytes in WML. Conclusions: Ang II vaccination restored WML as well as cognitive function in 2VO rats. Our findings suggested that Ang II vaccination ameliorated cerebrovascular endothelial dysfunction which could accelerate the OPCs differentiation through increased expression of FGF2 in endothelial cells or astrocytes in 2VO rats.

Cerebral White Matter Lesions have Low Impact on Cognitive Function in a Large Elderly Memory Clinic Population

2018 ◽  
Vol 63 (3) ◽  
pp. 1129-1139 ◽  
Author(s):  
Jules J. Claus ◽  
Mirthe Coenen ◽  
Salka S. Staekenborg ◽  
Jacqueline Schuur ◽  
Caroline E.M. Tielkes ◽  
...  
Keyword(s):  
Cognitive Function ◽  
White Matter ◽  
White Matter Lesions ◽  
Cerebral White Matter ◽  
Memory Clinic ◽  
Cerebral White Matter Lesions ◽  
Clinic Population

White matter lesions, cerebral inflammation and cognitive function in a mouse model of cerebral hypoperfusion

2019 ◽  
Vol 1711 ◽  
pp. 193-201 ◽  
Author(s):  
Hagar Ben-Ari ◽  
Tzuri Lifschytz ◽  
Gilly Wolf ◽  
Amihai Rigbi ◽  
Tamar Blumenfeld-Katzir ◽  
...  
Keyword(s):  
Cognitive Function ◽  
White Matter ◽  
Mouse Model ◽  
White Matter Lesions ◽  
Cerebral Hypoperfusion ◽  
Cerebral Inflammation

Medication overuse headache: Investigtion of integrity and volume of the white matter

2017 ◽  
Vol 381 ◽  
pp. 427-428
Author(s):  
Y. Beckmann ◽  
S. Gökçe ◽  
N. Zorlu ◽  
S. Türe ◽  
F. Gelal
Keyword(s):  
White Matter ◽  
Medication Overuse ◽  
Medication Overuse Headache

Deep versus Periventricular White Matter Lesions and Cognitive Function in a Community Sample of Middle-Aged Participants

2012 ◽  
Vol 18 (5) ◽  
pp. 874-885 ◽  
Author(s):  
Juan José Soriano-Raya ◽  
Júlia Miralbell ◽  
Elena López-Cancio ◽  
Núria Bargalló ◽  
Juan Francisco Arenillas ◽  
...  
Keyword(s):  
Cognitive Function ◽  
White Matter ◽  
Executive Functioning ◽  
Verbal Fluency ◽  
Community Sample ◽  
White Matter Lesions ◽  
High Grade ◽  
Psychomotor Speed ◽  
Middle Aged ◽  
Visuospatial Skills

AbstractThe association of cerebral white matter lesions (WMLs) with cognitive status is not well understood in middle-aged individuals. Our aim was to determine the specific contribution of periventricular hyperintensities (PVHs) and deep white matter hyperintensities (DWMHs) to cognitive function in a community sample of asymptomatic participants aged 50 to 65 years. One hundred stroke- and dementia-free adults completed a comprehensive neuropsychological battery and brain MRI protocol. Participants were classified according to PVH and DWMH scores (Fazekas scale). We dichotomized our sample into low grade WMLs (participants without or with mild lesions) and high grade WMLs (participants with moderate or severe lesions). Analyses were performed separately in PVH and DWMH groups. High grade DWMHs were associated with significantly lower scores in executive functioning (−0.45 standard deviations [SD]), attention (−0.42 SD), verbal fluency (−0.68 SD), visual memory (−0.52 SD), visuospatial skills (−0.79 SD), and psychomotor speed (−0.46 SD). Further analyses revealed that high grade DWMHs were also associated with a three- to fourfold increased risk of impaired scores (i.e.,<1.5 SD) in executive functioning, verbal fluency, visuospatial skills, and psychomotor speed. Our findings suggest that only DWMHs, not PVHs, are related to diminished cognitive function in middle-aged individuals. (JINS, 2012, 18, 1–12)

Thalamic diffusion differences related to cognitive function in white matter lesions

2014 ◽  
Vol 35 (5) ◽  
pp. 1103-1110 ◽  
Author(s):  
Marina Fernández-Andújar ◽  
Juan José Soriano-Raya ◽  
Júlia Miralbell ◽  
Elena López-Cancio ◽  
Cynthia Cáceres ◽  
...  
Keyword(s):  
Cognitive Function ◽  
White Matter ◽  
White Matter Lesions

scholarly journals The Association between Cerebral White Matter Lesions and Plasma Omega-3 to Omega-6 Polyunsaturated Fatty Acids Ratio to Cognitive Impairment Development

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Michihiro Suwa ◽  
Shigeru Yamaguchi ◽  
Tsuyoshi Komori ◽  
Sachiko Kajimoto ◽  
Masaya Kino
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
White Matter ◽  
White Matter Lesions ◽  
White Matter Hyperintensity ◽  
Cerebral White Matter ◽  
Omega 3 ◽  
Arachidonic Acids ◽  
Low Serum

Objective. Cerebral white matter hyperintensity (WMH) with magnetic resonance imaging (MRI) has a potential for predicting cognitive impairment. Serum polyunsaturated fatty acid (PUFA) levels are important for evaluating the extent of atherosclerosis. We investigated whether abnormal PUFA levels affected WMH grading and cognitive function in patients without significant cognitive impairment.Methods. Atherosclerotic risk factors, the internal carotid artery (ICA) plaque, and serum ratios of eicosapentaenoic to arachidonic acids (EPA/AA) and docosahexaenoic to arachidonic acids (DHA/AA) were assessed in 286 patients. The relationship among these risk factors, WMH, and cognitive function was evaluated using WMH grading and the Mini-Mental State Examination (MMSE).Results. The development of WMH was associated with aging, hypertension, ICA plaques, and a low serum EPA/AA ratio (<0.38, obtained as the median value) but was not related to dyslipidemia, diabetes, smoking, and a low serum DHA/AA ratio (<0.84, obtained as the median value). In addition, the MMSE score deteriorated slightly with the progression of WMH (29.7 ± 1.0 compared to 28.4 ± 2.1,P<0.0001).Conclusions. The progression of WMH was associated with a low serum EPA/AA ratio and accompanied minimal deterioration in cognitive function. Sufficient omega-3 PUFA intake may be effective in preventing the development of cognitive impairment.

Sign in / Sign up

Export Citation Format

Share Document