scholarly journals Morphological analysis of age-related iridocorneal angle changes in normal and glaucomatous cases using anterior segment optical coherence tomography

2013 ◽  
pp. 113
Author(s):  
Yuko Maruyama ◽  
Kazuhiko Mori ◽  
Yoko Ikeda ◽  
Morio Ueno ◽  
Shigeru Kinoshita
Keyword(s):  
Optical Coherence Tomography ◽  
Morphological Analysis ◽  
Anterior Segment ◽  
Optical Coherence ◽  
Iridocorneal Angle ◽  
Age Related

scholarly journals The Use of Anterior-Segment Optical-Coherence Tomography for the Assessment of the Iridocorneal Angle and Its Alterations: Update and Current Evidence

2021 ◽  
Vol 10 (2) ◽  
pp. 231
Author(s):  
Giacinto Triolo ◽  
Piero Barboni ◽  
Giacomo Savini ◽  
Francesco De Gaetano ◽  
Gaspare Monaco ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Intraocular Pressure ◽  
Clinical Relevance ◽  
Anterior Segment ◽  
Angle Closure ◽  
Current Evidence ◽  
Optical Coherence ◽  
Iridocorneal Angle ◽  
Wide Range

The introduction of anterior-segment optical-coherence tomography (AS-OCT) has led to improved assessments of the anatomy of the iridocorneal-angle and diagnoses of several mechanisms of angle closure which often result in raised intraocular pressure (IOP). Continuous advancements in AS-OCT technology and software, along with an extensive research in the field, have resulted in a wide range of possible parameters that may be used to diagnose and follow up on patients with this spectrum of diseases. However, the clinical relevance of such variables needs to be explored thoroughly. The aim of the present review is to summarize the current evidence supporting the use of AS-OCT for the diagnosis and follow-up of several iridocorneal-angle and anterior-chamber alterations, focusing on the advantages and downsides of this technology.

scholarly journals Accidental Corneal Intrastromal Intraocular Lens Implantation with the Wound-Assisted Technique and Clinical Course with Anterior Segment Optical Coherence Tomography

2021 ◽  
pp. 283-287
Author(s):  
Jo Moriya ◽  
Shinichi Sakamoto ◽  
Satoru Inoda ◽  
Hidenori Takahashi ◽  
Hidetoshi Kawashima
Keyword(s):  
Optical Coherence Tomography ◽  
Intraocular Lens ◽  
Anterior Segment ◽  
Corneal Stroma ◽  
Age Related Macular Degeneration ◽  
Optical Coherence ◽  
Corrected Visual Acuity ◽  
Age Related ◽  
Intracameral Injection ◽  
Air Tamponade

Accidental intraocular lens (IOL) implantation into the corneal stroma is a rare clinical entity that can occur during the wound-assisted technique. In this report, we describe a case of an 81-year-old man who underwent cataract surgery in which the IOL was implanted into the corneal stroma with the wound-assisted technique, and we present changes in anterior segment optical coherence tomography. The IOL was removed and reinserted after widening the incision. Air tamponade was created by intracameral injection. An anterior chamber tap was performed 10 h later to reduce increased intraocular pressure. Interlayer separation of the corneal stroma was confirmed 30 min postoperatively but was corrected 4 days later. The patient’s best-corrected visual acuity (BCVA) was logMAR 0.30, and he had been diagnosed with age-related macular degeneration before surgery. Although the opacity of the corneal stroma persisted, BCVA improved to logMAR 0. When using the wound-assisted technique for IOL insertion, surgeons should take care not to implant the IOL into the corneal stroma.

scholarly journals Age-Related Changes in the Rhesus Macaque Eye

2021 ◽  
Author(s):  
Kira Lin ◽  
Tu Tran ◽  
Soohyun Kim ◽  
Sangwan Park ◽  
Jiajia Chen ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Intraocular Pressure ◽  
Rhesus Macaque ◽  
Axial Length ◽  
Rhesus Macaques ◽  
Anterior Segment ◽  
Optical Coherence ◽  
Lens Thickness ◽  
Age Related ◽  
Age Related Changes

Purpose: To assess age-related changes in the rhesus macaque eye and evaluate them to corresponding human age-related eye disease. Methods: Data from eye exams and imaging tests including intraocular pressure (IOP), lens thickness, axial length, and retinal optical coherence tomography (OCT) images were evaluated from 142 individuals and statistically analyzed for age-related changes. Quantitative autofluorescence (qAF) was measured as was the presence of macular lesions as related to age. Results: Ages of the 142 rhesus macaques ranged from 0.7 to 29 years (mean=16.4 years, stdev=7.5 years). Anterior segment measurements such as IOP, lens thickness, and axial length were acquired. Advanced retinal imaging in the form of optical coherence tomography and qAF were obtained. Quantitative assessments were made and variations by age groups were analyzed to compare with established age-related changes in human eyes. Quantitative analysis of data revealed age-related increase in intraocular pressure, ocular biometry (lens thickness and axial length), and presence of macular lesions. Age-related changes in thicknesses of retinal layers on OCT were observed and quantified. Age was correlated with increased qAF. Conclusions: The rhesus macaque has age-related ocular changes similar to humans. IOP increases with age while retinal ganglion cell layer thickness decreases. Macular lesions develop in some aged animals. Our findings support the concept that rhesus macaques may be useful for the study of important age-related diseases such as glaucoma, macular diseases, and cone disorders, and for development of therapies for these diseases.

scholarly journals Assessment of anterior chamber configuration changes after phacoemulsification with swept-source optical coherence tomography

2019 ◽  
Author(s):  
Man Hu ◽  
Qian Zheng ◽  
Zhangliang Li ◽  
Pingjun Chang ◽  
Yun-e Zhao
Keyword(s):  
Optical Coherence Tomography ◽  
Cataract Surgery ◽  
Anterior Chamber ◽  
Anterior Segment ◽  
Anterior Chamber Depth ◽  
Optical Coherence ◽  
Swept Source ◽  
Narrow Angle ◽  
Age Related ◽  
Shallow Anterior Chamber

Abstract Background To assess the changes of anterior chamber angle in patients with shallow anterior chamber and normal anterior chamber after phacoemulsification and intraocular lens implantation (IOL) using anterior segment swept-source optical coherence tomography (AS-SS-OCT). Methods This was a prospective case control study; 60 eyes of 60 patients who underwent cataract surgery. Based on anterior chamber depth (ACD) and gonioscopy findings, the eyes were classified into two groups, shallow anterior chamber group (30 eyes) and normal anterior chamber group (30 eyes). AS-SS-OCT was used to measure ACD and angle parameters angle opening distance (AOD), angle recess area (ARA), trabecular iris space area(TISA), and trabecular iris angle (TIA). Serial changes in each group were measured before and 3 months after phacoemulsification and IOL, and the differences between the two groups were compared. Results All angle parameters including ACD, AOD, ARA, TISA, and TIA in both groups at 3 months after cataract surgery were significantly different from the preoperative values (p<0.01). In addition, we found significant differences of all angle parameters between groups of shallow anterior chamber (SAC) and normal anterior chamber (NAC) (All P< 0.05). Besides, the TISA750 in superior quadrant and anterior chamber volume (ACV) were significantly smaller in the group of SAC than those in the group of NAC (P = 0.041 and 0.002, respectively). Conclusions The parameters of anterior chamber increased significantly in both two groups but not increase to the same extent 3 months after phacoemulsification. Iris thickening may also be one of the narrow angle factors,not just age-related lens thickening.

scholarly journals Quantitative Analysis of Lens Nuclear Density Using Optical Coherence Tomography (OCT) with a Liquid Optics Interface: Correlation between OCT Images and LOCS III Grading

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
You Na Kim ◽  
Jin Hyoung Park ◽  
Hungwon Tchah
Keyword(s):  
Optical Coherence Tomography ◽  
Anterior Segment ◽  
Nuclear Density ◽  
Optical Coherence ◽  
Pixel Intensity ◽  
Age Related ◽  
Corrected Distance Visual Acuity ◽  
Positive Linear Correlation ◽  
Lens Opacities ◽  
Imagej Software

Purpose. To quantify whole lens and nuclear lens densities using anterior-segment optical coherence tomography (OCT) with a liquid optics interface and evaluate their correlation with Lens Opacities Classification System III (LOCS III) lens grading and corrected distance visual acuity (BCVA).Methods. OCT images of the whole lens and lens nucleus of eyes with age-related nuclear cataract were analyzed using ImageJ software. The lens grade and nuclear density were represented in pixel intensity units (PIU) and correlations between PIU, BCVA, and LOCS III were assessed.Results. Forty-seven eyes were analyzed. The mean whole lens and lens nuclear densities were 26.99 ± 5.23 and 19.43 ± 6.15 PIU, respectively. A positive linear correlation was observed between lens opacities (R2= 0.187,p<0.01) and nuclear density (R2= 0.316,p<0.01) obtained from OCT images and LOCS III. Preoperative BCVA and LOCS III were also positively correlated (R2= 0.454,p<0.01).Conclusions. Whole lens and lens nuclear densities obtained from OCT correlated with LOCS III. Nuclear density showed a higher positive correlation with LOCS III than whole lens density. OCT with a liquid optics interface is a potential quantitative method for lens grading and can aid in monitoring and managing age-related cataracts.

scholarly journals Swept Source Optical Coherence Tomography Analysis of the Selected Eye’s Anterior Segment Parameters

2021 ◽  
Vol 10 (5) ◽  
pp. 1094
Author(s):  
Michał Dembski ◽  
Anna Nowińska ◽  
Klaudia Ulfik-Dembska ◽  
Edward Wylęgała
Keyword(s):  
Optical Coherence Tomography ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Optical Coherence ◽  
Swept Source ◽  
Iridocorneal Angle ◽  
Glaucoma Diagnosis ◽  
Good Repeatability ◽  
Anterior Segment Parameters ◽  
Important Marker

Background: The present study determined the mean reference values of the anterior segment parameters of the selected eye using swept source optical coherence tomography (SS-OCT) in healthy Caucasian participants. Methods: A total of 166 volunteers (age 54–79 years), women (n = 92) and men (n = 74), were analyzed. One eye of each subject was randomly selected for anterior segment imaging. The anterior segment of the eye was scanned with CASIA2. The analyzed anterior segment parameters were divided into three groups, namely parameters of the cornea, lens, and angle. Results: The OCT (e.g., Ks, Kf, pKf, pKs, and central corneal thickness) and Fourier parameters of the cornea were significantly different between females and males. The iridocorneal angle was the smallest in the upper quadrant for all distance from the apex of the angle (250, 500, and 750 µm). Conclusions: Therefore, SS-OCT enables the analysis of parameters of the cornea, anterior chamber, lens, and iridocorneal angle, highlighting its clinical utility. Sex-specific differences in the analyzed parameters should be taken into account during the diagnosis of corneal diseases. The configuration of the filtration angle is an important marker during glaucoma diagnosis and drainage implant surgery. Measurements with CASIA 2is characterized by very good repeatability.

scholarly journals Precise geometry of the anterior chamber of the eye by means of OCT imaging.

2018 ◽  
Vol 10 (3) ◽  
pp. 67
Author(s):  
Marta Katarzyna Skrok ◽  
Damian Siedlecki ◽  
David Alonso-Caneiro
Keyword(s):  
Optical Coherence Tomography ◽  
Anterior Chamber ◽  
Anterior Segment ◽  
Anterior Chamber Depth ◽  
Distortion Correction ◽  
Diagnostic Methods ◽  
Optical Distortion ◽  
Optical Coherence ◽  
Refractive Index Measurement ◽  
Iridocorneal Angle

Nowadays medicine highly relies on non-invasive optical diagnostic methods. The likewise situation is in the case of ophthalmology, especially in diagnosis of anterior segment eye diseases, where optical coherence tomography (OCT) plays inestimable role. OCT devices can do fast, painless measurements of the anterior segment of the eye. Nonetheless it should be remembered that the OCT images are burdened with an optical distortion and they doesn’t reflect the true geometry of the eye. This study presents an algorithm for correcting the distortion in OCT images and reflecting true parameters of the anterior segment of the eye. Full Text: PDF ReferencesA. Podoleanu, I. Charalambous, L. Plesea, A. Dogariu, R. Rosen, "Correction of distortions in optical coherence tomography imaging of the eye", Phys. Med. Biol. 49(7), 1277 (2004). CrossRef S. Ortiz, D. Siedlecki, I. Grulkowski, L. Remon, D. Pascual, M. Wojtkowski, S. Marcos, "Optical distortion correction in Optical Coherence Tomography for quantitative ocular anterior segment by three-dimensional imaging", Opt. Express 18, 2782 (2010). CrossRef F. LaRocca, S.J. Chiu, R.P. McNabb, A.N. Kuo, J.A. Izatt, S. Farsiu, "Robust automatic segmentation of corneal layer boundaries in SDOCT images using graph theory and dynamic programming", Biom. Opt. Express 2(6), 1524 (2011). CrossRef S.A. Read et al., "Anterior eye tissue morphology: Scleral and conjunctival thickness in children and young adults", Sci. Rep. 6, 33796 (2016). CrossRef S.R. Uhlhorn, D. Borja, F. Manns, J.-M. Parel, "Refractive index measurement of the isolated crystalline lens using optical coherence tomography", Vision Res., 48(27), 2732 (2008). CrossRef R. Koprowski, Z. Wróbel, S. Wilczyński, A. Nowińska, E. Wylęgała, "Methods of measuring the iridocorneal angle in tomographic images of the anterior segment of the eye", Biomed. Eng. Online, 12, 40 (2013). CrossRef D.P. Pinero, A.B. Plaza Puche, J.L. Alio, "Corneal diameter measurements by corneal topography and angle-to-angle measurements by optical coherence tomography: Evaluation of equivalence", J. Cataract Refract. Surg. 34, 126 (2008). CrossRef B. Urban, M. Krętowska, M. Szumiński, A. Bakunowicz-Łazarczyk, " Evaluation of anterior chamber depth measurements in emmetropic, hypermetropic and myopic eyes in children and adolescents using OCT Visante", Klinika Oczna 114(1), 18 (2012). DirectLink L. Chen, D. Chernyak, "Pupil Changes under Scotopic and Photopic illumination", Invest. Ophthalmol. Vis. Sci. 54, 1524 (2013). DirectLink D. Monsalvez-Romin, A.J. del Aguila-Carrasco, T. Ferrer-Blasco, J.J. Esteve-Taboada, R Montes-Mico, Evaluation of the iridocorneal angle with accommodation using optical coherence tomography", Int. J. Ophthalmol. 10(10), 1614 (2017). CrossRef

scholarly journals Characteristics and variability of iridocorneal angle: an anterior segment optical coherence tomography study

2022 ◽  
Vol 100 (S267) ◽  
Author(s):  
Ouederni Meriem ◽  
Nafaa Fehmy ◽  
Rym Maamouri ◽  
Sassi Hela ◽  
Insaf Mrad ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Anterior Segment ◽  
Optical Coherence ◽  
Iridocorneal Angle

scholarly journals Trabecular-Iris Circumference Volume in Open Angle Eyes Using Swept-Source Fourier Domain Anterior Segment Optical Coherence Tomography

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Mohammed Rigi ◽  
Lauren S. Blieden ◽  
Donna Nguyen ◽  
Alice Z. Chuang ◽  
Laura A. Baker ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Age Groups ◽  
Anterior Segment ◽  
Analysis Of Covariance ◽  
Optical Coherence ◽  
Open Angle ◽  
Swept Source ◽  
Normal Ranges ◽  
Age Related ◽  
Effect Of Age

Purpose. To introduce a new anterior segment optical coherence tomography parameter, trabecular-iris circumference volume (TICV), which measures the integrated volume of the peripheral angle, and establish a reference range in normal, open angle eyes.Methods. One eye of each participant with open angles and a normal anterior segment was imaged using 3D mode by the CASIA SS-1000 (Tomey, Nagoya, Japan). Trabecular-iris space area (TISA) and TICV at 500 and 750 µm were calculated. Analysis of covariance was performed to examine the effect of age and its interaction with spherical equivalent.Results. The study included 100 participants with a mean age of 50 (±15) years (range 20–79). TICV showed a normal distribution with a mean (±SD) value of 4.75 µL (±2.30) for TICV500 and a mean (±SD) value of 8.90 µL (±3.88) for TICV750. Overall, TICV showed an age-related reduction(P=0.035). In addition, angle volume increased with increased myopia for all age groups, except for those older than 65 years.Conclusions. This study introduces a new parameter to measure peripheral angle volume, TICV, with age-adjusted normal ranges for open angle eyes. Further investigation is warranted to determine the clinical utility of this new parameter.

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