UNRAVELLING THE REGULATORY ACCEPTANCE OF IN- VITRO MEAT CULTURE

Innovators of in vitro meat (IVM) are convinced that this approach is the solution for problems related to current meat production and consumption, especially regarding animal welfare and environmental issues. However, the production conditions have yet to be fully clarified and there is still a lack of ethical discourses and critical debates on IVM. In consequence, discussion about the ethical justifiability and desirability of IVM remains hypothetical and we have to question those promises. This paper addresses the complex ethical aspects associated with IVM and the questions of whether, and under what conditions, the production of IVM represents an ethically justifiable solution for existing problems, especially in view of animal welfare, the environment, and society. There are particular hopes regarding the benefits that IVM could bring to animal welfare and the environment, but there are also strong doubts about their ethical benefits.

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Modelling the growth of in-vitro meat on microstructured edible films

Journal of Food Engineering ◽

10.1016/j.jfoodeng.2021.110662 ◽

2021 ◽

pp. 110662

Author(s):

Aldonza Jaques ◽

Elizabeth Sánchez ◽

Nicole Orellana ◽

Javier Enrione ◽

Cristian A. Acevedo

Keyword(s):

Edible Films ◽

In Vitro Meat

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Test guideline development and animal welfare: Regulatory acceptance of in vitro studies

Reproductive Toxicology ◽

10.1016/0890-6238(93)90077-k ◽

1993 ◽

Vol 7 ◽

pp. 117-123 ◽

Cited By ~ 6

Author(s):

Herman B.W.M. Koëter

Keyword(s):

Animal Welfare ◽

Guideline Development ◽

In Vitro Studies ◽

Regulatory Acceptance ◽

Test Guideline

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Visions of In Vitro Meat among Experts and Stakeholders

NanoEthics ◽

10.1007/s11569-018-0330-0 ◽

2018 ◽

Vol 12 (3) ◽

pp. 211-224 ◽

Cited By ~ 4

Author(s):

Inge Böhm ◽

Arianna Ferrari ◽

Silvia Woll

Keyword(s):

In Vitro Meat

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Culturing Food: Bioart and In Vitro Meat

Parallax ◽

10.1080/13534645.2013.743296 ◽

2013 ◽

Vol 19 (1) ◽

pp. 88-100 ◽

Cited By ~ 3

Author(s):

Allison Carruth

Keyword(s):

In Vitro Meat

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The Matter of In-Vitro Meat: Speculative Genres of Future Life

The Palgrave Handbook of Twentieth and Twenty-First Century Literature and Science ◽

10.1007/978-3-030-48244-2_21 ◽

2020 ◽

pp. 375-395

Author(s):

Coleman Nye

Keyword(s):

In Vitro Meat

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In vitro meat production system: why and how?

Journal of Food Science and Technology ◽

10.1007/s13197-015-1972-3 ◽

2015 ◽

Vol 52 (12) ◽

pp. 7599-7607 ◽

Cited By ~ 23

Author(s):

Shruti Sharma ◽

Sukhcharanjit Singh Thind ◽

Amarjeet Kaur

Keyword(s):

Production System ◽

Meat Production ◽

In Vitro Meat

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Research on the development of alternatives to animal testing for pharmaceutical products and international standardisation

Impact ◽

10.21820/23987073.2021.8.44 ◽

2021 ◽

Vol 2021 (8) ◽

pp. 44-45

Author(s):

Hajime Kojima

Keyword(s):

Research Group ◽

Pharmaceutical Products ◽

In Vitro Assays ◽

Animal Testing ◽

3 Dimensional ◽

Alternatives To Animal Testing ◽

Gene Assay ◽

Innovative Work ◽

Regulatory Acceptance

Scientists are working to develop new and innovative alternatives to animal testing that don't rely on the use of animals. Takao Ashikaga, Hajime Kojima and Yoko Hirabayashi are part of JaCVAM which works to promote the use of alternatives to animal testing. The goal is to replace, reduce or refine (3Rs) the use of animal under International harmonization. Hirabayashi is also the representative of a research group that is funded by the AMED and the representative of a research group funded by the MHLW. A challenge the researchers are facing in their quest to ensure the welfare of experimental animals and also ensure the safety of various pharmaceutical and chemicals is the lack of biomarkers to more accurately predict toxicity for regulatory acceptance. This means that without animal testing more costly and complex non-animal methods are required and presents a barrier to the adoption of non-animal methods for international standerisation. As such, there is a need to develop an easy way to obtain a lot of information. Hirabayashi and the team are working on the development of AI that can be used to evaluate the safety of different compounds. The researchers are developing in vitro assays such as ordinary 2-dimensional culture, 3-dimensional culture including organoids or spheroids, reporter gene assay and organ-on-a chip; and in silico assays such as computer toxicology using QSAR and Read Across. The researchers hope that their innovative work will contribute to the 3Rs, benefiting animal welfare for regulatory use.

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