scholarly journals RADIOLOGICAL TESTS VERSUS PATHOLOGICAL DIAGNOSTICS: COMPLIMENTARY OR ANTAGONISTIC RELATIONSHIP- AN INSTITUTIONAL EXPERIENCE

2021 ◽  
Vol 9 (11) ◽  
pp. 1077-1083
Author(s):  
Indira Sahu ◽  
Suman Ruhela ◽  
Laghuta Verma
Keyword(s):  
Diagnostic Accuracy ◽  
Breast Imaging ◽  
Analytical Study ◽  
Data System ◽  
Breast Lesions ◽  
Radiological Findings ◽  
Cross Sectional ◽  
Standard Material ◽  
The Core ◽  
Institutional Experience

Aims & Objective: To determine the yield, reliability and diagnostic accuracy of Breast Imaging Reporting and Data System in evaluation of breast lesions taking histopathology as gold standard. Material and Methods: This cross-sectional, analytical study was conducted at Pathology dept. Of SMSMC Jaipur from June 2019 to June 2020. The data of the core needle biopsies of breast lesions received at the Pathology department which had been also categorized on mammogram, according to the Breast Imaging Reporting and Data System (BI-RADS), were selected for the study. All clinical parameters, the site of the biopsy, the radiological findings, the pathological diagnoses were studied. The concordance between the radiological and pathological results was studied . According to BI-RADS, categories II and III were classified as benign and BI-RADs IV and V as malignant. The breast core biopsies were classified as benign and malignant, according to the diagnosis. Results: A total of 115 patients were included in the study. BI-RADS system for reporting whencompared with histopathology had sensitivity of 93.55%, specificity 68.18%, positive predictive value92.55%, negative predictive value 71.43% and diagnostic accuracy 88.70%. Conclusion: The findings of this study report a high diagnostic accuracy of BI-RADS in the diagnosis ofbreast carcinoma.

scholarly journals Diagnostic accuracy of digital breast tomosynthesis in combination with 2D mammography for the characterisation of mammographic abnormalities

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Vithya Visalatchi Sanmugasiva ◽  
Marlina Tanty Ramli Hamid ◽  
Farhana Fadzli ◽  
Faizatul Izza Rozalli ◽  
Chai Hong Yeong ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Breast Imaging ◽  
Digital Breast Tomosynthesis ◽  
Asian Population ◽  
Architectural Distortion ◽  
Breast Lesions ◽  
Cross Sectional ◽  
Breast Tomosynthesis ◽  
Full Field

AbstractThis study aims to assess the diagnostic accuracy of digital breast tomosynthesis in combination with full field digital mammography (DBT + FFDM) in the charaterisation of Breast Imaging-reporting and Data System (BI-RADS) category 3, 4 and 5 lesions. Retrospective cross-sectional study of 390 patients with BI-RADS 3, 4 and 5 mammography with available histopathology examination results were recruited from in a single center of a multi-ethnic Asian population. 2 readers independently reported the FFDM and DBT images and classified lesions detected (mass, calcifications, asymmetric density and architectural distortion) based on American College of Radiology-BI-RADS lexicon. Of the 390 patients recruited, 182 malignancies were reported. Positive predictive value (PPV) of cancer was 46.7%. The PPV in BI-RADS 4a, 4b, 4c and 5 were 6.0%, 38.3%, 68.9%, and 93.1%, respectively. Among all the cancers, 76% presented as masses, 4% as calcifications and 20% as asymmetry. An additional of 4% of cancers were detected on ultrasound. The sensitivity, specificity, PPV and NPV of mass lesions detected on DBT + FFDM were 93.8%, 85.1%, 88.8% and 91.5%, respectively. The PPV for calcification is 61.6% and asymmetry is 60.7%. 81.6% of cancer detected were invasive and 13.3% were in-situ type. Our study showed that DBT is proven to be an effective tool in the diagnosis and characterization of breast lesions and supports the current body of literature that states that integrating DBT to FFDM allows good characterization of breast lesions and accurate diagnosis of cancer.

scholarly journals Diagnosis of breast lumps based on breast imaging reporting and data system score and histopathological examination: a comparative study

2019 ◽  
Vol 7 (1) ◽  
pp. 144
Author(s):  
Shahaji G. Chavan ◽  
Sree Ganesh B. ◽  
Nandan Vemuri
Keyword(s):  
Diagnostic Accuracy ◽  
Predictive Value ◽  
Gold Standard ◽  
Breast Imaging ◽  
Histopathological Examination ◽  
Breast Cancer Incidence ◽  
Data System ◽  
Breast Lump ◽  
Cross Sectional ◽  
Breast Lumps

Background: Breast cancer incidence in India is increasing and has now become the most common cancer among women. Preoperative pathology diagnosis and mammography (using breast imaging reporting and data system      (BI-RADS) scoring system) constitute an essential part of the workup of breast lesions. The present study was aimed to compare the diagnostic accuracy of BI-RADS score with histopathological finding in diagnosis of benign and malignant lesions of breast.Methods: This is a cross-sectional study. The present study was conducted on 100 randomly selected newly diagnosed cases of breast lump attending the General Surgery Department (OPD).Results: Considering histopathological examination as gold standard, the sensitivity and specificity of BI-RADS score is 93.9% and 82.3% respectively. The positive predictive value, negative predictive value and diagnostic accuracy of BI-RADS score is 91.1%, 87.5% and 90.0% respectively.Conclusions: Author conclude from the present study that BI-RADS score being non-invasive, it may become a very useful test for evaluating Breast lump lesions. However, BI-RADS score cannot be considered as gold standard and thus cannot be used as an alternative to histopathology in diagnosis of breast lumps.

scholarly journals The importance of breast elastography added to the BI-RADS® (5th edition) lexicon classification

2015 ◽  
Vol 61 (4) ◽  
pp. 313-316 ◽  
Author(s):  
Eduardo de Faria Castro Fleury
Keyword(s):  
Diagnostic Accuracy ◽  
Breast Imaging ◽  
Percutaneous Biopsy ◽  
Data System ◽  
Breast Lesions ◽  
Conventional Ultrasound ◽  
Reporting Data ◽  
Breast Elastography

SummaryObjective:the aim of this study was to investigate the addition of elastography to the BI-RADS® lexicon for the classification of breast lesions.Methods:a total of 955 consecutive patients who were subjected to breast percutaneous biopsy from January 2010 to December 2012 were retrospectively assessed. Overall, 26 patients who did not present with masses on conventional ultrasound were excluded. The patients were classified according to the fifth edition of the breast imaging and reporting data system (BI-RADS®) lexicon, which includes elastographic findings. The BI-RADS®classification is based on the same classification principles that have been suggested by the author, which classify lesions as soft, intermediate, or hard.Results:the addition of elastographic findings to the BI-RADS® lexicon improved the sensitivity (S), specificity (SP), and diagnostic accuracy (DA) of ultrasound in the assessment of breast lesions, which increased from 93.85, 72.07, and 76.64 to 95.90, 80.65, and 91.39%, respectively.Conclusion:these findings suggest that the addition of elastography to the BIRADS ® lexicon will improve the SP and DA of ultrasound in the screening of breast lesions.

scholarly journals Diagnostic Accuracy of Lower Uterine Segment Scar Thickness ≤1.6mm in Prediction of Scar Dehiscence in patients

2021 ◽  
Vol 15 (10) ◽  
pp. 2682-2684
Author(s):  
Fiza Asif ◽  
Sobia Zafar ◽  
Tehmina Zafar ◽  
Tayyaba Majeed ◽  
Zahid Mahmood
Keyword(s):  
Cesarean Section ◽  
Diagnostic Accuracy ◽  
Gold Standard ◽  
Lower Uterine Segment ◽  
Transvaginal Sonography ◽  
Cross Sectional ◽  
Standard Material ◽  
Lower Segment Cesarean Section ◽  
Study Results ◽  
Uterine Scar

Background: Cesarean section uterine scar dehiscence (CSD) is a rare but notable complication of Lower segment cesarean section (LSCS) surgery. The cause for a uterine scar dehiscence is based on the etiology behind the uterine scar defect or any event that would predispose the cesarean scar to dehisce. Globally accepted option for assessing the CS scar is transvaginal ultrasonography of the non-pregnant uterus. Objective: To determine the diagnostic accuracy of lower uterine segment scar thickness≤1.6mm in the prediction of scar dehiscence in patients with previous one LSCS who are undergoing repeat LSCS after trial of labour taking intraoperative findings as gold standard. Material and methods: This cross sectional study was conducted in Services Hospital, Lahore for 6 months. The Non probability consecutive sampling technique was used to include women with previous one LSCS at 36-38 weeks were asked to get their TVS done for scar thickness. Women with scar thickness≤1.6mm and scar thickness>1.6mm were identified. Their intraoperative findings of scar dehiscence were confirmed. All the data was entered and analyzed on SPSS version 20. Results: The mean age of patients was 29.87±6.07 years. The emergency LSCS was done in 599(49.1%) patients and elective LSCS was done in 621(50.9%) patients. The sensitivity, specificity & diagnostic accuracy of TVS was 98.31%, 99.05% & 98.69% respectively. Conclusion: According to our study results the TVS for uterine scar is a very useful and effective tool in the prediction of scar dehiscence in patients with previous one LSCS taking intraoperative findings as gold standard. Keywords: Transvaginal sonography, TVS, Uterine, Scar, dehiscence, LSCS, Intraoperative

scholarly journals Prevalence of c-myc expression in breast lesions associated with microcalcifications detected by routine mammography

2009 ◽  
Vol 127 (2) ◽  
pp. 66-70 ◽  
Author(s):  
Renato Coimbra Mazzini ◽  
Simone Elias ◽  
Afonso Celso Pinto Nazário ◽  
Cláudio Kemp ◽  
Ângela Flávia Logullo
Keyword(s):  
Breast Imaging ◽  
Ductal Carcinoma ◽  
Percutaneous Biopsy ◽  
Screening Mammography ◽  
University Hospital ◽  
Premalignant Lesions ◽  
Breast Lesions ◽  
Benign Lesions ◽  
Cross Sectional ◽  
Malignant Lesions

CONTEXT AND OBJECTIVE: Genetic abnormalities in cell proliferation-regulating genes have been described in premalignant lesions. The aims here were to evaluate c-myc protein expression in non-palpable breast lesions associated with microcalcifications, detected by screening mammography, and to compare these results with histopathological, clinical and epidemiological variables. DESIGN AND SETTING: Analytical cross-sectional study, with retrospective data collection, in a university hospital in São Paulo. METHODS: Seventy-nine female patients who underwent routine mammography between 1998 and 2004 were studied. Lesions classified by the Breast Imaging Reporting and Data System (BI-RADS) as 4 or 5 underwent percutaneous biopsy using a large-core needle. Ninety-eight lesions were studied anatomopathologically. Paraffin blocks properly representing the lesions were selected for immunohistochemical analyses using the streptavidin-biotin-peroxidase technique with monoclonal mouse c-myc antibodies. RESULTS: Among the 98 lesions, 29 (29.6%) contained malignant neoplasia; 40 (40.8%) had a positive immunohistochemical reaction for c-myc. When the groups were divided between lesions without atypias versus atypical lesions plus malignant lesions, 31.03% of the 58 lesions without atypias were positive for c-myc and 55% of the 40 malignant and atypical lesions (P = 0.018). Comparing the atypical lesions with ductal carcinoma in situ versus the benign lesions without atypias, c-myc was present in 51.61% of the 31 atypical lesions and 31.03% of the benign lesions without atypias (P = 0.057). CONCLUSION: C-myc protein was more frequently expressed in atypical and malignant lesions than in benign lesions without atypias. C-myc expression correlated with the presence of atypias (P = 0.018).

Diagnostic Accuracy of MRC in Benign and ML in Obstructive Jaundice Patients, Taking Histopathology as Gold Standard

2021 ◽  
Vol 15 (12) ◽  
pp. 3421-3423
Author(s):  
Kamran Naseem ◽  
Malik Mudasir Hassan ◽  
Sarah Nisar
Keyword(s):  
Magnetic Resonance ◽  
Obstructive Jaundice ◽  
Diagnostic Accuracy ◽  
Gold Standard ◽  
False Negative ◽  
Magnetic Resonance Cholangiopancreatography ◽  
True Negative ◽  
Cross Sectional ◽  
Standard Material ◽  
Malignant Lesions

Objectives: To find out the diagnostic accuracy of magnetic resonance cholangiopancreatography in benign and malignant lesions in patients of obstructive jaundice, taking histopathology as gold standard. Material and methods: This cross sectional study was conducted at Department of Radiology, Bahawal Victoria Hospital, Bahawalpur October 2019 to April 2020. A total of 164 patients with suspected cases of obstructive jaundice and age 25-65 years of either gender were included. Then magnetic resonance cholangiopancreatography (MRCP) was performed in every patient by 1.5 Tesla MR System using a torso phased-array coil. After this, each patient was undergone operation in the concerned ward. Findings of MRCP were compared with the findings of histopathology. Results: In MRCP positive patients, 78 were true positive (TP) and 13 were false positive (FP). Among 73, MRCP negative patients, 08 were false negative (FN) whereas 65 were True Negative (TN). Overall specificity, sensitivity, NPV, PPV and diagnostic accuracy of magnetic resonance cholangiopancreatography in benign and malignant lesions in patients of obstructive jaundice, taking histopathology as gold standard was 90.70%, 83.33%, 85.71%, 89.04% and 87.20% respectively. Conclusion: This study concluded that magnetic resonance cholangiopancreatography (MRCP) is the non-invasive modality of choice with diagnostic accuracy in diagnosing in benign and malignant lesions in obstructive jaundice patients. Keywords: obstructive jaundice, sensitivity, magnetic resonance imaging.

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