scholarly journals CHARACTERISTICS OF THE AMINO ACID PROFILE IN CHILDREN WITH IMPAIRED MOTOR ACTIVITY OF THE GASTROINTESTINAL TRACT

2018 ◽  
Vol 63 (5) ◽  
pp. 75-80
Author(s):  
A. A. Ziganshina ◽  
V. S. Sukhorukov ◽  
V. P. Bulatov
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Gastrointestinal Tract ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Motor Activity ◽  
Reflux Disease ◽  
Functional Constipation ◽  
Amino Acid Profile ◽  
Healthy Children

Purpose.To identify the characteristics of the amino acid profile in children with various disturbances of the motor activity of the gastrointestinal tract. We examined 100 patients treated at the diagnostic department of the Children’s Republican Clinical Hospital of Tatarstan. The main group consisted of 80 patients, 40 of whom were diagnosed with functional constipation, and 40 patients were diagnosed with endoscopically verified gastroesophageal reflux disease. The control group consisted of 20 somatically healthy children with no signs of pathology of the gastrointestinal tract. We determined the content of amino acids in dry blood stains using liquid tandem chromatography-mass spectrometry on Agilent Technologies 6410 Triple Quad LC/MC (USA). We performed statistical analysis of the results using GraphPad InStat (version 3.05; 2000) and Statistica 10.0.Results.We found differences in the amino acid composition of blood of the patients with impaired motor activity of the digestive tract as compared to healthy children. The level of leucine was increased to the greatest extent in the study group. The revealed changes correlated with the severity of the disease.Conclusions. Disorders in the motor activity of the digestive organs are accompanied by changes in the amino acid profile that are associated with the severity of functional constipation and gastroesophageal reflux disease. Some amino acids, in particular leucine and arginine, can be used to diagnose secondary mitochondrial dysfunction in pediatric gastroenterology along with conventional biochemical and chromatomass-spectrometric markers.

Combined detection of inorganic syndromes of the gastrointestinal tract and their differential diagnosis.

2021 ◽  
Vol 2021 (2) ◽  
pp. 68-71
Author(s):  
R.I. Khalafova ◽  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Differential Diagnosis ◽  
Gastrointestinal Tract ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Functional Dyspepsia ◽  
Military Personnel ◽  
Reflux Disease ◽  
Irritable Bowel ◽  
Combined Detection

To study the frequency of detection of combinations of the main syndromes of the gastrointestinal tract (GIT) and their differential diagnosis, consisting of irritable bowel syndrome (IBS), syndrome of functional dyspepsia (SFD), chronic idiopathic dyspepsia (CIT) and gastroesophageal reflux disease (GERD). The main gastrointestinal syndromes are quite often detected among different groups of military personnel and members of their families. ES plays an important role in their formation. International recommendations allow anamnestic diagnosis of each of the syndromes in separately and in combination with each other. The medical appealability of patients depends on the severity of the symptoms of the syndromes, it is most pronounced when they are combined.

scholarly journals Neuropsychiatric features of children with systemic somatovegetative disorders (by the example of atopic dermatitis, bronchial asthma and gastroesophageal reflux disease)

2019 ◽  
Vol 10 (3) ◽  
pp. 40-48
Author(s):  
T. S. Petrenko ◽  
K. Yu. Retyunskiy ◽  
M. D. Borovskikh ◽  
D. R. Devyatkina ◽  
A. V. Pereshitova ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Bronchial Asthma ◽  
Reflux Disease ◽  
Energy Functional ◽  
Control Group ◽  
Healthy Children ◽  
Central Nervous System Damage ◽  
Neuropsychological Disorders

Objective: to study the clinical neuropsychiatric and neuropsychological features of children suffering from systemic somatovegetative disorders.Materials and methods: the study involved children from 5 to 12 years old with an established diagnosis of bronchial asthma — 108 children; atopic dermatitis — 105 children; gastroesophageal reflux disease — 112 children; the control group consisted of 60 same age healthy children. All children underwent clinical-anamnestic, neurological, psychopathological and neuropsychological research.Results: the children with systemic somatovegetative disorders have a significantly high incidence of pathogenic factors of central nervous system damage in early stages of ontogenesis (pathology of pregnancy and childbirth). Early sensory and motor deprivation due to somatic suffering aggravates neuropsychiatric deficiency. Neuropsychological disorders were predominantly represented by a violation of the perception of their body, lack of kinesthetic and motor functions, spatial and quasi-spatial representations.Conclusion: the clinical dynamics of neuropsychiatric disorders in children with systemic somatovegetative disorders corresponds to the dynamics of residual cerebral organic impairment with a stage-age changes of syndromes. The revealed neuropsychological disorders correspond to preferential damage to the first (energy) functional block of the brain.

scholarly journals Peculiarities of the Pathology of Gastrointestinal Tract in Patients with Gastroesophageal Reflux Disease on the Background of Hypothyroidism

2021 ◽  
Vol 6 (1) ◽  
pp. 125-131
Author(s):  
Reva T. V. ◽  
◽  
V. B. Reva ◽  
I. V. Trefanenko ◽  
G. І. Shumko ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Gastroesophageal Reflux Disease ◽  
Gastric Mucosa ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Erosive Esophagitis ◽  
Control Group ◽  
Esophageal Mucosa ◽  
Gastric Evacuation ◽  
Duodenogastroesophageal Reflux

The article identifies the features of the pathology of the gastrointestinal tract in patients with gastroesophageal reflux disease on the background of hypothyroidism. The frequency of gastroesophageal reflux disease and the severity of this disease increase with age and the presence of comorbid pathology. In the elderly, the frequency of the typical esophageal manifestations decreases, and the erosive esophagitis with atypical symptoms is more common. The growing number of cases of combined thyroid dysfunction with gastropathology requires in-depth study of the reasons for the relationship between these processes. Pathological changes in the gastrointestinal tract in these patients make their condition severer, contributing to the development and progression of metabolic disorders. An important aggravating effect on the regulatory mechanisms of esophageal kinetics has a pathological functioning of the thyroid gland on the background of iodine deficiency. Results and discussion. In patients with gastroesophageal reflux disease with hypothyroidism, all changes in gastric and duodenal function are associated with a decrease in the acid-forming function of the gastric mucosa, due to its atrophy, decreased tone and contractility of the stomach. This in turn leads to a slowing of gastric and duodenal evacuation, dysfunction of the closing capacity of the cardia and, as a consequence, the development of duodenogastroesophageal reflux. The esophageal contents are not so pronounced, so patients with non-erosive forms of esophagitis predominate (46.2%) against 16% of patients in the second group (patients with gastroesophageal reflux disease). At the same time, erosive forms predominate among patients in the control group with predominant acid reflux. It should be noted that there is a clear relationship between the frequency of erosive changes in the esophageal mucosa and the duration of the disease. Thus, among patients of the main group with a 5-year history of the disease, the number of erosive forms of gastroesophageal reflux disease was minimal. The number of erosive changes in the esophageal mucosa increased sharply in patients with a 10-year history and reached its maximum after 15 years from the onset of the disease. Conclusion. The delay in gastric evacuation is more pronounced in patients with gastroesophageal reflux disease on the background of hypothyroidism. It can be explained by a decrease in gastric motility and the presence of duodenostasis. The slowing of gastric evacuation was more pronounced in patients with gastroesophageal reflux disease on the background of reduced thyroid function. In patients with gastroesophageal reflux disease on the background of hypothyroidism there is an alkaline duodenogastroesophageal reflux as a consequence of reduced acid-forming function of the gastric mucosa and reduced contractility of the stomach and duodenum

scholarly journals Differentiated approach to the examining children with chest pain

2021 ◽  
Vol 24 (1) ◽  
pp. 20-26
Author(s):  
Nataliya A. Berezneva ◽  
Olga I. Stenina ◽  
Andrey K. Uglitskikh
Keyword(s):  
Chest Pain ◽  
Gastrointestinal Tract ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Clinical Significance ◽  
Clinical Examination ◽  
Reflux Disease ◽  
Pain Syndrome ◽  
Clinical Analysis ◽  
Cardiac Pathology

The aim of this work is to determine the causes of chest pain in children with combined pathology and to develop an examination algorithm for chest pain. Materials and methods. Examined 20 children aged 7-18 years who consulted a pediatrician with pain complaints in the chest. To exclude the cardiac genesis of pain, all patients underwent electrocardiography and echocardiography; the rest of the examinations were prescribed, taking into account the anamnesis and clinical examination data. Results. According to the examination results, most patients were found to have gastrointestinal tract pathology: gastroesophageal reflux disease, chronic gastritis, biliary tract dysfunction. Against the background of adherence to a diet and taking medications prescribed by a gastroenterologist, their pain syndrome subsided, which confirmed the noncardial genesis of thoracalgia. A clinical analysis of cases of combined (cardiac and non-cardiac) pathology was carried out, an algorithm for examining children with chest pain was presented. Discussion. The causes of chest pain in children and the tactics of managing these patients are discussed, the clinical significance of the history and clinical examination data in drawing up a plan for the examination of such patients is determined.

Diet Advancement after Weight Loss Surgery

2018 ◽  
Author(s):  
Laura Andromalos
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Gastrointestinal Tract ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Postoperative Period ◽  
Reflux Disease ◽  
Weight Loss Surgery ◽  
Early Postoperative Period ◽  
Defecatory Dysfunction

Diet advancement after bariatric surgery has not been standardized across various bariatric programs. It is generally agreed that patients should advance through a textured progression while the gastrointestinal tract heals; however, the content of each diet stage is open for interpretation. The postoperative diet is intended to promote healing and weight loss while minimizing diet-related complications. This review presents the literature regarding the progression of patients through a postoperative bariatric surgery diet, macro- and micronutrient needs in the early postoperative period, and management of common diet-related complications, including nausea, dumping syndrome, gastroesophageal reflux disease, and defecatory dysfunction. This review contains 5 tables and 45 references Key words: Bariatric surgery, bariatric surgery diet, postoperative diet, macro-nutrient needs, micro-nutrient needs, diet-related complications

Su1089 Prevalence of Gastroesophageal Reflux Disease in Patients With Upper Gastrointestinal Tract Symptoms in Thailand

2012 ◽  
Vol 142 (5) ◽  
pp. S-421
Author(s):  
Somchai Leelakusolvong ◽  
Chuanpit Suttinont ◽  
Paitoon Nitipitichai ◽  
Manoch Ouwuttipong ◽  
Pitinun Puapatanakul ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Upper Gastrointestinal Tract ◽  
Upper Gastrointestinal

The overlap of gastroesophageal reflux disease and functional constipation in children

2017 ◽  
Vol 29 (11) ◽  
pp. 1264-1268 ◽  
Author(s):  
Masallah Baran ◽  
Yeliz Cagan Appak ◽  
Miray Karakoyun ◽  
Sevda Yalcinkaya ◽  
Kayi Eliacik ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Functional Constipation

scholarly journals The study of oral liquid microcrystallization in children with gastro-esophageal reflux disease

2014 ◽  
Vol 87 (4) ◽  
pp. 269-276
Author(s):  
Aurelia Spinei ◽  
Alina Monica Picos ◽  
Ina Romanciuc ◽  
Antonela Berar ◽  
Ana Maria Mihailescu
Keyword(s):  
Electron Microscope ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Control Group ◽  
Study Group ◽  
Healthy Children ◽  
Esophageal Reflux ◽  
Oral Liquid ◽  
Scanning Electron

Background and aim. Patients with disabilities have a higher prevalence of caries and dental erosions than general population. This particularity may be assessed by the study of microcrystallization of saliva. We investigated the oral liquid microcrystallization in children with gastroesophageal reflux disease (GERD), a condition associated with dental erosions. Material and methods. 54 children have been clinically examined: 27 children suffering from GERD with ages between 13 and 15, were included in the study group, and 27 healthy children - the control group. The study of crystallographic changes of the oral liquid was performed using the method developed by Shatohina, Razumov SN, Shabalin VN (2006) with the scanning electron microscope VEGA TESCAN TS 5130 MM. Results. The degree of microcrystalization of the oral liquid in children with GERD was considerably reduced, (1.73±0.11 points) and was lower than in children in the control group (3.22±0.16 points) (p<0.01, RR=2). The degree of micro-crystallization of oral liquid in children with GERD was 1.86 times lower than in healthy children. This was correlated with the duration of gastroesophageal reflux. Conclusion. The study of structural particularities of dehydrated droplet of oral liquid in children with GERD has elucidated a number of markers of the changes produced in the oral cavity. These can be used in the screening research in prevention of caries and dental erosions. 

scholarly journals State of respiratory function and features of airway inflammation in children with asthma combined with gastroesophageal reflux disease

2021 ◽  
pp. 62-65
Author(s):  
A.A. Buratynska ◽  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Lung Function ◽  
Gastroesophageal Reflux ◽  
Airway Inflammation ◽  
Reflux Disease ◽  
Induced Sputum ◽  
Bronchial Obstruction ◽  
Healthy Children ◽  
Children With Asthma ◽  
The Difference

The prevalence of gastroesophageal reflux disease (GERD) in children with asthma ranges from 32% to 80%. The intensity of respiratory symptoms, bronchial obstruction are more pronounced in children with asthma combined with GERD than in children with isolated asthma. However, there are limited and conflicting data on the difference between the induced sputum in asthmatic children with or without GERD. Purpose — to examine the status of lung function and features of airway inflammation in children with asthma combined with gastroesophageal reflux disease. Materials and methods. Sixty-seven children ages 6–17 years with moderate asthma and 30 healthy children ages 6–17 years were observed. They were assigned to three groups: group 1 (32 children with isolated asthma), and group 2 (35 children with asthma and GERD) and group 3 (30 healthy children). All children included in the study were identical in age and gender. Clinical assessment, spirometry with test of reversibility of airway obstruction, and cytological analysis of induced sputum samples were performed on all patients. Upper gastrointestinal endoscopy was done in the asthmatic groups. Results. There were 10 (28.57%) children in the 2nd group with first degree obstructive spirometry pattern and none in the 1st group of children. First degree restrictive spirometry pattern was more significant observed in the 1st group of children — 10 (31.25%) than in the 2nd group of children — 2 (5.71%) (OR, CI 95% 7.50 (1.50–37.57)). In the 2nd group of children, induced sputum had a significantly higher number of neutrophils, lymphocytes and macrophages compared to the 3rd group (p<0.05). Also the difference between these parameters were significant compared to the 1st group of children. The number of induced sputum epithelial cells in 2nd group was significantly less than in 1st group of children. Conclusions. GERD negatively affects the parameters of lung function in children with asthma. Airway inflammation in children with asthma combined with GERD appears to be more significant compared to isolated asthma. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of an participating institution. The informed consent of the child's parents was obtained from the studies. No conflict of interest was declared by the authors. Key words: asthma, gastroesophageal reflux disease, children, spirometry, induced sputum.

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