Synthesis and Characterization of calcium Starch: A New Controlled Release Polymer for floating tablets of Losartan Potassium

2021 ◽  
pp. 219-226
Author(s):  
K. Naga Prathyusha ◽  
B. Hemalatha ◽  
K. Padmalatha
Keyword(s):  
Controlled Release ◽  
Potato Starch ◽  
Oral Dosage ◽  
Losartan Potassium ◽  
Direct Compression ◽  
Compression Technique ◽  
Floating Tablets ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System

Losartan potassium is used to treat high blood pressure (hypertension). The present study was aimed to prepare a floating drug delivery system to design a controlled release oral dosage form of Losartan potassium. This helps to overcome the demerit of limited residence time of the drug in the gastrointestinal track and hence to increase the duration of release. Hence objective of the present study is to develop Losartan potassium floating tablets by direct compression method using calcium starch as release retarding polymer. The calcium starch was synthesized by gelatinizing potato starch in the presence of sodium hydroxide and cross linking by treatment with calcium chloride. The micromeritic properties studies indicated that calcium starch is a promising pharmaceutical excipient in tablets. Floating tablets of Losartan potassium was formulated by direct compression technique, using different concentration of calcium starch and compared with HPMC K-100 as release retard polymer. As the amount of calcium starch in the tablet increased, the drug release decreased. The formulation F5 containing 125 mg calcium starch showed better controlled release of 76.38% after 12 hours.

scholarly journals DEVELOPMENT AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF A QUINAPRIL HCL BY DIRECT COMPRESSION TECHNIQUE

2017 ◽  
Vol 9 (8) ◽  
pp. 35 ◽  
Author(s):  
Audumbar Digambar Mali ◽  
Ritesh Suresh Bathe
Keyword(s):  
Drug Delivery ◽  
Citric Acid ◽  
Drug Release ◽  
Lag Time ◽  
Direct Compression ◽  
Compression Technique ◽  
Floating Tablets ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System

Objective: The present study was undertaken with an objective to design, develop and evaluate gastro retentive floating tablets of an antihypertensive drug, quinapril HCl, which release the drug in a sustained manner over a period of 12 h.Methods: In this research work, we used hydrophilic polymer hydroxypropyl methylcellulose (HPMC K4M), the gas generating agent sodium bicarbonate and citric acid at different ratios for the preparation of tablets. A 32 factorial design was applied systematically; the amount of HPMC K4M (X1) and the amount of citric acid (X2) were selected as independent variables. The dependent variables chosen were percentage drug release at 6 h (Q6), percentage drug release at 12 h (Q12) and floating lag time. The high concentration of HPMC K4M and citric acid gives a sustained release for quinapril HCl floating tablets. The tablets were prepared by direct compression technique and evaluated for tablet thickness, hardness, weight variation, friability, floating lag time and In vitro drug release.Results: The In vitro drug release indicated the floating dosage forms showed slower release when the concentration of HPMC K4M increases. Formulation F4 having ratio 25:8 (HPMC K4M: citric acid) was considered as an optimised formulation which shows satisfactory sustained drug release and remained buoyant on the surface of the medium for more than 12 h. It can also conclude that floating drug delivery system of quinapril HCl can be successfully formulated as an approach to increase gastric residence time and thereby improving its bioavailability.Conclusion: The developed effervescent based floating tablets are a promising floating drug delivery system for oral sustained administration of quinapril HCl.

FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF CANDESARTAN CELEXETIL BY DIRECT COMPRESSION

INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (03) ◽  
pp. 23-27
Author(s):  
Y Dange ◽  
D Randive ◽  
S Bhinge ◽  
M. Bhutkar ◽  
G. Wadkar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Magnesium Stearate ◽  
Direct Compression ◽  
Floating Tablets ◽  
Weight Variation ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System

The objective was to develop optimized gastric floating drug delivery system (GFDDS) of candesartan celexetil floating tablets by using various polymers like Eudragit and MCC. In the present work, attempts have been made to prepare candesartan celexetil by direct compression method by using Citric acid, NaHCO3, Magnesium stearate, Eudragit and MCC. Formulations (F1 to F4) of floating tablets of candesartan celexetil were prepared using variable concentrations of Eudragit and MCC. The prepared formulations were evaluated for thickness, hardness, weight variation, friability, drug content and uniformity. The buoyancy lag time and the total floating time was studied for all the formulations. Formulation F4 of sustained release tablet of Candesartan celexetil containing a combination of both polymers was found to be the optimized formulation for 13 hours release as it fulfilled all the requirement of floating drug delivery system of sustained release dosage form.

scholarly journals Preparation and in vitro characterization of non-effervescent floating drug delivery system of poorly soluble drug, carvedilol phosphate

2014 ◽  
Vol 64 (4) ◽  
pp. 485-494 ◽  
Author(s):  
Venkata Srikanth Meka ◽  
Vanitha A/P Hong Wee Liang ◽  
Senthil Rajan Dharmalingham ◽  
Ravi Sheshala ◽  
Adinarayana Gorajana
Keyword(s):  
Polyethylene Oxide ◽  
Xanthan Gum ◽  
Solid Dispersions ◽  
Floating Tablets ◽  
In Vitro Characterization ◽  
Floating Drug Delivery ◽  
Poorly Soluble ◽  
Floating Drug Delivery System

Abstract The objective of the study was to enhance the solubility of carvedilol phosphate and to formulate it into non-effervescent floating tablets using swellable polymers. Solid dispersions (SD) of carvedilol were prepared with hydrophilic carriers such as polyvinylpyrrolidone and poloxamer to enhance solubility. Non-effervescent floating tablets were prepared with a combination of optimized solid dispersions and release retarding polymers/swellable polymers such as xanthan gum and polyethylene oxide. Tablets were evaluated for physicochemical properties such as hardness, thickness and buoyancy. SD prepared with the drug to poloxamer ratio of 1:4 by melt granulation showed a higher dissolution rate than all other dispersions. Formulations containing 40 mg of polyethylene oxide (C-P40) and 50 mg xanthan gum (C-X50) were found to be best, with the drug retardation up to 12 hours. Optimized formulations were characterized using FTIR and DSC and no drug and excipient interactions were detected.

scholarly journals Controlled Release of Oral Tetrahydrocurcumin from a Novel Self-Emulsifying Floating Drug Delivery System (SEFDDS)

2010 ◽  
Vol 12 (1) ◽  
pp. 152-164 ◽  
Author(s):  
Saipin Setthacheewakul ◽  
Wichan Kedjinda ◽  
Duangkhae Maneenuan ◽  
Ruedeekorn Wiwattanapatapee
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System

scholarly journals FORMULATION AND IN VITROEVALUATION OF FLOATING TABLETS OF CEFPODOXIME PROXETIL

2017 ◽  
Vol 9 (6) ◽  
pp. 18 ◽  
Author(s):  
Bharat W. Tekade ◽  
Umesh T. Jadhao ◽  
Shruti G. Patil ◽  
Vijay R. Patil
Keyword(s):  
Research Work ◽  
Physical Parameters ◽  
Content Uniformity ◽  
Compression Technique ◽  
Disintegration Time ◽  
Floating Tablets ◽  
Cefpodoxime Proxetil ◽  
Ir Studies ◽  
Weight Variation ◽  
Floating Drug Delivery System

Objective: The objective of research work was to formulate and evaluate the floating drug delivery system containing Cefpodoxime Proxetil using polymer HPMC K4M, Guar Gum.Methods: Effervescent floating tablets containing Cefpodoxime proxetil were prepared by direct compression technique using varying concentrations of different grades of polymer.Results: Physical parameters like hardness, weight variation, thickness and friability were within pharmacopoeial limit. Percentage drug content in all floating tablet formulations was found to be 90% to 110%. The floating time was found to be more than 12 H. floating lag time was found to be 10±2.99 second. Formulation batch F8 was selected as an optimum formulation, as possessing less disintegration time, higher water absorption ratio and good content uniformity i.e. within acceptable limit.% drug release of formulation batch F8 was found to be 96.66% in 0.1 N HCL.Conclusion: The FT-IR studies of batch F8 was carried out which showed the peak values within the spectrum corresponding to the peak values of pure drug.

A novel automated alternating current biosusceptometry method to characterization of controlled-release magnetic floating tablets of metronidazole

2013 ◽  
Vol 40 (8) ◽  
pp. 1123-1131 ◽  
Author(s):  
Priscileila Colerato Ferrari ◽  
Dany Bruno Borella dos Santos Grossklauss ◽  
Matheus Alvarez ◽  
Fabiano Carlos Paixão ◽  
Uilian Andreis ◽  
...  
Keyword(s):  
Controlled Release ◽  
Alternating Current ◽  
Floating Tablets

Optimization and characterization of gastroretentive floating drug delivery system using Box-Behnken design

2012 ◽  
Vol 39 (12) ◽  
pp. 1928-1935 ◽  
Author(s):  
Kishore Rapolu ◽  
Krishna Sanka ◽  
Praveen Kumar Vemula ◽  
Vinaydas Aatipamula ◽  
Abdul Bari Mohd ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Box Behnken Design ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System

scholarly journals Formulation and Dissolution Study of Valsartan Immediate Release Tablets

2013 ◽  
Vol 1 (02) ◽  
pp. 01-08
Author(s):  
B. Brahmaiah ◽  
K. Sasikanth ◽  
Sreekanth Nama ◽  
P. Suresh ◽  
Patan Adam Khan
Keyword(s):  
Potato Starch ◽  
Immediate Release ◽  
Magnesium Stearate ◽  
In Vitro Dissolution ◽  
Direct Compression ◽  
Dissolution Profile ◽  
Compression Technique ◽  
Dissolution Studies ◽  
Main Motive

In the present study, design of oral immediate release tablets of Valsartan by direct compression technique was carried out. The main aim and objective of the work is to formulate immediate release tablets using different direct compression vehicles (DCV’S) in different ratios. The main motive is to compare the dissolution profile of these formulations and conclude the best formulation which release drug at a faster rate. To determine the best fit dissolution profile for the dosage forms. Valsartan tablets were formulated by using microcrystalline cellulose (diluents), potato starch, acacia (binder) and magnesium stearate (lubricant). The granules were compressed into tablets and were subjected to dissolution studies. The dissolution profile of the formulation F2 was found to have better dissolution rate compared to others. The In-vitro dissolution studies of all the formulations were conducted and the results were obtained, it was concluded that formulation F2 was the best with fast release of drug compared to others.

scholarly journals FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING BIOADHESIVE TABLETS OF HYDROCHLORTHIAZIDE

2017 ◽  
Vol 10 (5) ◽  
pp. 150
Author(s):  
Ramu Bandameedi ◽  
Shanmunga Pandiyan P
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Xanthan Gum ◽  
Zero Order ◽  
Direct Compression ◽  
Compression Technique ◽  
First Order ◽  
Gastric Residence Time ◽  
Weight Variation ◽  
Kinetic Treatment

Objective: Floating bioadhesive tablets of hydrochlorothiazide were developed to prolong gastric residence time leading to an increase in drugbioavailability where here a combination of floating and bioadhesion mechanism is combined.Methods: Tablets are prepared by direct compression technique using polymers xanthan gum, carbopol 974 P, HPMC K15M, HPMC K100M, magnesiumStearate USP-NF (Avicel PH 102), microcrystalline cellulose Ph 102, Talc, and sodium bicarbonate.Results: Tablets were evaluated for their physical characteristics, namely, hardness, thickness, friability and weight variation, drug content, andfloating properties. The best formulation subjected for kinetic treatment, i.e., zero order, first order, peppas, Higuchi, and Hixon-crowel. The R valuesare 0.9366, 0.9364, 0.9680, 0.9974, and 0.9283, respectively.Conclusion: Optimized formulae F4 containing polymers HPMC K4M and CARBOPOL 974 P showed more bioadhesion with a controlled release over12 hrs. Therefore, formulation F4 identified as a successful formulation for the development of floating bioadhesive tablets.Keywords: Hydrochlorothiazide, Floating tablets, Gastroretentive drug delivery system.

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