Lack of association between vitamin D receptor Taq I polymorphism and diabetic nephropathy in type 2 diabetes mellitus patients

2020 ◽  
Vol 58 (1) ◽  
pp. 1-7
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Vitamin D Receptor

scholarly journals VITAMIN D RECEPTOR GENE POLYMORPHISMS AND HAPLOTYPE ANALYSIS IN TYPE 2 DIABETES MELLITUS PATIENTS FROM NORTH INDIA

2017 ◽  
Vol 10 (10) ◽  
pp. 248
Author(s):  
Nancy Taneja ◽  
Rajesh Khadgawat ◽  
Shalini Mani
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Vitamin D Receptor ◽  
Mutant Allele ◽  
Haplotype Analysis ◽  
Vdr Gene ◽  
Vdr Polymorphisms

  Objective: Vitamin D receptor (VDR) mediated Vitamin D signaling is important for expression of insulin gene and glucose transporters, which help in glucose uptake by cells. Current evidence suggests that four common polymorphisms (FokI, BsmI, ApaI, TaqI) of VDR gene are associated with Type 2 diabetes mellitus (T2DM) in different populations. However, there is a scarcity of data on VDR polymorphisms from Indian population.Methods: In the current study, total genomic DNA was isolated from 100 well-characterized T2DM patients and 100 healthy controls. We investigated the prevalence of FokI and ApaI polymorphisms in VDR gene of these patients by polymerase chain reaction-restriction fragment length polymorphism-based method. Taking help of our previous published data on TaqI and BsmI polymorphisms in same patients, the haplotype study was also conducted. Statistical analysis of data was performed using SPSS 21.0 software. Haplotype and linkage disequilibrium analysis was performed by Haploview software.Results: Both the wild (TT) and mutant (CC) genotype of FokI polymorphism showed a significant difference between patients and controls (p<0.001 and p<0.001, respectively). The frequency of mutant allele (C) was also significantly higher in T2DM patients than the controls (p<0.001). In case of ApaI, frequency of wild (GG) and mutant (CC) genotype was significantly different in patients and controls (p=0.017 and p=0.034). As per haplotype analysis, the CACT haplotype was predicted to be of significance in patients and consists of mutant alleles of three polymorphisms (FokI, BsmI, ApaI). Conclusion: Our study supports the association of FokI and ApaI polymorphism in T2DM. The haplotype analysis also indicates that the combinations of mutant allele of different VDR polymorphisms are probably responsible for increased susceptibility of these individuals toward T2DM.

scholarly journals Associations between Vitamin D and Type 2 Diabetes Mellitus: The Role of Vitamin D Receptor and Binding Protein

2020 ◽  
Vol 10 (04) ◽  
pp. 222-235
Author(s):  
Eman S. Arafat ◽  
Inass M. Taha ◽  
Shahad W. Kattan ◽  
Nouf Abubakr Babteen ◽  
Iman Fawzy
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Vitamin D Receptor ◽  
Binding Protein

Vitamin D receptor gene polymorphisms among Emirati patients with type 2 diabetes mellitus

2018 ◽  
Vol 175 ◽  
pp. 119-124 ◽  
Author(s):  
Habiba Al Safar ◽  
Sarah El Hajj Chehadeh ◽  
Laila Abdel-Wareth ◽  
Afrozul Haq ◽  
Herbert F. Jelinek ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Receptor Gene Polymorphisms

The vitamin D receptor functional variant rs2228570 (C>T) does not associate with type 2 diabetes mellitus

2017 ◽  
Vol 42 (4) ◽  
pp. 331-335 ◽  
Author(s):  
Laura Bertoccini ◽  
Federica Sentinelli ◽  
Frida Leonetti ◽  
Diego Bailetti ◽  
Danila Capoccia ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Vitamin D Receptor ◽  
Functional Variant

scholarly journals Asosiasi antara Status Vitamin D 25(Oh)D dengan Albuminuria pada Pasien Diabetes Melitus Tipe 2

2017 ◽  
Vol 4 (1) ◽  
pp. 16
Author(s):  
Tities Anggraeni Indra ◽  
Aida Lydia ◽  
Dyah Purnamasari ◽  
Siti Setiati
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Vitamin D Deficiency ◽  
Blood Glucose Control ◽  
Chi Square ◽  
Diabetes Melitus

Pendahuluan. Angka kejadian nefropati diabetik di Indonesia dilaporkan meningkat. Defisiensi vitamin D juga cukup tinggi. Berbagai faktor telah diidentifikasi turut memperberat kejadian nefropati diabetik salah satunya status vitamin D 25(OH)D. Namun demikian, bekum ada studi yang mengidentifikasi hubungan keduanya di Indonesia. Penelitian ini bertujuan untuk mengetahui asosiasi antara status vitamin D 25(OH)D dengan albuminuria pada pasien diabetes melitus tipe 2 di Indonesia.Metode. Dilakukan studi potong lintang pada 96 pasien diabetes melitus (DM) tipe 2 yang berobat ke poliklinik MetabolikEndokrin Fakultas Kedokteran Universitas Indonesia/Rumah Sakit dr. Cipto Mangunkusumo (FKUI/RSCM), Jakarta pada November-Desember 2012. Pemeriksaan kadar vitamin D 25(OH)D diilakukan dengan menggunakan kit Diasorin dengan metode CLIA, sedangkan albuminuria dinilai berdasarkan kadar albumin pada sampel urin sewaktu. Uji statistik yang digunakan meliputi uji chi square pada analisis bivariat dan regresi logistik pada analisis multivariat.Hasil. Prevalensi defisiensi vitamin D 25(OH)D pada pasien diabetes melitus tipe 2 sebesar 49% dengan nilai median kadar vitamin D 25(OH)D adalah 16,35 (4,2-41,4) ng/mL. Tidak didapatkan adanya hubungan yang bermakna secara statistik antara defisiensi vitamin D dengan albuminuria, baik pada analisis bivariat maupun multivariat (OR 0,887; IK95% 0,3352,296). Faktor perancu yang memengaruhi hubungan antara defisiensi vitamin D dengan kejadian albuminuria pada pasien DM tipe 2 adalah kontrol gula darah yang buruk dan berat badan lebih.Simpulan. Studi ini belum dapat menyimpulkan adanya hubungan antara defisiensi vitamin D 25(OH)D dengan albuminuria pada pasien DM tipe 2 di Indonesia.Kata Kunci: albuminuria, defisiensi vitamin D 25(OH)D, DM tipe 2  The Association between Vitamin D 25(OH)D Level and Albuminuria in Type 2 Diabetes MellitusIntroduction. Vitamin D 25(OH)D deficiency was reported as a possible risk factor for the development of diabetic nephropathy in several epidemiologic studies. Whether vitamin D 25(OH)D deficiency plays a role in the development of diabetic nephropathy in Indonesia is unknown. This study aims to determinate the association between vitamin D 25(OH)D level with albuminuria in patients with type 2 diabetes mellitus in Indonesia. Methods. A cross-sectional study was conducted in 96 patients with type 2 diabetes mellitus at outpatient clinic of MetabolicEndocrine Cipto Mangunkusumo Hospital. Serum vitamin D level was assessed using Diasorin kit with CLIA method, while albuminuria was assessed using random urine sample. Statistical analysis was conducted using chi square for bivariate analysis and regression logistic method for multivariate analysis. Results.The prevalence of vitamin D 25(OH)D deficiency in patients with type 2 diabetes mellitus was 49% with a median value 16,35 (4,2-41,4) ng/mL. There was no significant correlation between vitamin D deficiency with the severity of albuminuria (OR 0,887; 95% CI 0,335 to 2,296). Confounding factors such as poor blood glucose control and overweight strongly influenced the association between vitamin D deficiency with the incidence of albuminuria in patients with type 2 diabetes mellitus. Conclusion. The results of this study showed that there was no association between vitamin D deficiency with the severity of albuminuria in patients with type 2 diabetes mellitus in Indonesia. 

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