THE EFFECT OF BONE MARROW DERIVED MESENCHYMAL STEM CELLS ON THE ULTRASTRUCTURE OF SUBMANDIBULAR SALIVARY GLAND OF INDUCED HYPOTHYROIDISM IN RATS (ELECTRON MICROSCOPIC STUDY)

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Dina Eldahrawy ◽  
Heba Adawy ◽  
Mona El Deeb
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Salivary Gland ◽  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Submandibular Salivary Gland ◽  
Electron Microscopic

Exosomes Derived from Bone Marrow-Derived Mesenchymal Stem Cells (BM-MSC) Protect Submandibular Glands in Diabetic Rats

2021 ◽  
Vol 11 (11) ◽  
pp. 2168-2173
Author(s):  
Cong Zhang ◽  
Xiaohong Zhang ◽  
Min Zhang
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Salivary Gland ◽  
Salivary Glands ◽  
Serum Amylase ◽  
Diabetic Rats ◽  
Submandibular Salivary Gland ◽  
Amylase Level ◽  
Group I

Our study assess whether exosomes derived from bone marrow mesenchymal stem cells (BM-MSC) ameliorates diabetic salivary gland complications. 10 SD rats were assigned into diabetes group I and exosome treatment group II. Diabetic rats were induced by streptozotocin (STZ) and injected with DMSO or exosomes through tail vein followed by collection of submandibular salivary gland samples for histological analysis and TGFβ, Smad2 and Smad3 level by PCR, saliva IgA and serum amylase level. Compared with control mice, exosome treatment mice showed less fibrosis of the submandibular salivary glands and duct components with a more complete structure. Exosome treatment inhibited TGFβ, Smad2 and Smad3 level to reduce diabetic salivary gland complications, effectively decreased blood sugar level, improved salivary glands function with significantly reduced serum amylase and salivary IgA levels. In conclusion, BM-MSC-derived exosomes may be a new therapeutic strategy for treating diabetic salivary gland complications.

Electron microscopic study of the progeny of ependymal stem cells in the normal and injured spinal cord

2005 ◽  
Vol 64 ◽  
pp. S28-S32 ◽  
Author(s):  
Ayhan Attar ◽  
Erkan Kaptanoglu ◽  
Zafer Aydın ◽  
Murat Ayten ◽  
Mustafa F. Sargon
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Injured Spinal Cord ◽  
Electron Microscopic
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