Role of Sesame Oil in Ameliorating Testicular Damage in a Rat Model of Acute Kidney Injury: A Histological and Immunohistochemical Study

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Marwa Ibrahim ◽  
Heba Sharaf eldin ◽  
Mona Sadek
Keyword(s):  
Acute Kidney Injury ◽  
Rat Model ◽  
Immunohistochemical Study ◽  
Kidney Injury ◽  
Sesame Oil ◽  
Testicular Damage

scholarly journals Role of Retama Raetam on Gentamicin-Induced Acute Kidney Injury in Experimental Rat Model

2021 ◽  
Vol 13 (2) ◽  
pp. 35-45
Author(s):  
Medhat Menshawy ◽  
Abdel Razik Farrag ◽  
Sayed El Toumy ◽  
Gamila Muhamed
Keyword(s):  
Acute Kidney Injury ◽  
Rat Model ◽  
Kidney Injury ◽  
Retama Raetam ◽  
Experimental Rat Model

Chrysoeriol Attenuates Cisplatin Induced Acute Kidney Injury in A Rat Model by Regulating PI3K/AKT and NF-κB Pathways

2021 ◽  
Vol 19 (3) ◽  
pp. 366-372
Author(s):  
Chichang Qiu ◽  
Ying Xu
Keyword(s):  
Acute Kidney Injury ◽  
Rat Model ◽  
Inflammatory Diseases ◽  
Kidney Injury ◽  
Histopathological Changes ◽  
Antioxidant Capacities ◽  
Anti Inflammatory

Chrysoeriol is a flavonoid with anti-inflammatory and antioxidant capacities against inflammatory diseases. Inflammation and apoptosis participate in the pathogenesis of cisplatin-induced nephrotoxicity. The role of chrysoeriol on acute kidney injury in a cisplatin induced rat model was investigated in this study. An evaluation of the effect of chrysoeriol on cisplatininduced nephrotoxicity by measuring histopathological changes and proinflammatory biomarkers revealed activation of PI3K/AKT and inactivation of NF-κB pathways in the reno-protection by chrysoeriol.

Dopamine treatment attenuates acute kidney injury in a rat model of deep hypothermia and rewarming – The role of renal H2S-producing enzymes

2015 ◽  
Vol 769 ◽  
pp. 225-233 ◽  
Author(s):  
George J. Dugbartey ◽  
Fatemeh Talaei ◽  
Martin C. Houwertjes ◽  
Maaike Goris ◽  
Anne H. Epema ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Rat Model ◽  
Kidney Injury ◽  
Deep Hypothermia

scholarly journals A zebrafish model of infection-associated acute kidney injury

2018 ◽  
Vol 315 (2) ◽  
pp. F291-F299 ◽  
Author(s):  
Xiaoyan Wen ◽  
Liyan Cui ◽  
Seth Morrisroe ◽  
Donald Maberry ◽  
David Emlet ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Unmet Need ◽  
Kidney Injury ◽  
Edwardsiella Tarda ◽  
Adult Zebrafish ◽  
Zebrafish Model ◽  
Pericardial Edema ◽  
Kidney Injury Molecule 1 ◽  
Dose Dependent

Sepsis-associated acute kidney injury (S-AKI) independently predicts mortality among critically ill patients. The role of innate immunity in this process is unclear, and there is an unmet need for S-AKI models to delineate the pathophysiological response. Mammals and zebrafish ( Danio rerio) share a conserved nephron structure and homologous innate immune systems, making the latter suitable for S-AKI research. We introduced Edwardsiella tarda to the zebrafish. Systemic E. tarda bacteremia resulted in sustained bacterial infection and dose-dependent mortality. A systemic immune reaction was characterized by increased mRNA expressions of il1b, tnfa, tgfb1a, and cxcl8-l1 ( P < 0.0001, P < 0.001, P < 0.001, and P < 0.01, respectively). Increase of host stress response genes ccnd1 and tp53 was observed at 24 h postinjection ( P < 0.0001 and P < 0.05, respectively). Moderate E. tarda infection induced zebrafish mortality of over 50% in larvae and 20% in adults, accompanied by pericardial edema in larvae and renal dysfunction in both larval and adult zebrafish. Expression of AKI markers insulin-like growth factor-binding protein-7 (IGFBP7), tissue inhibitor of metalloproteinases 2 (TIMP-2), and kidney injury molecule-1 (KIM-1) was found to be significantly increased in the septic animals at the transcription level ( P < 0.01, P < 0.05, and P < 0.05) and in nephric tubules compared with noninfected animals. In conclusion, we established a zebrafish model of S-AKI induced by E. tarda injection, with both larval and adult zebrafish showing nephron injury in the setting of infection.

Acute kidney injury secondary to renal large B-cell lymphoma: role of early renal biopsy

2010 ◽  
Vol 43 (1) ◽  
pp. 237-240 ◽  
Author(s):  
Suhail Al-Salam ◽  
Ahmad Shaaban ◽  
Maha Alketbi ◽  
Naveed U. Haq ◽  
Samra Abouchacra
Keyword(s):  
Acute Kidney Injury ◽  
B Cell ◽  
Renal Biopsy ◽  
Cell Lymphoma ◽  
Kidney Injury ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Large B Cell
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